DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SmydA-5 and dao

DIOPT Version :9

Sequence 1:	NP_610202.3	Gene:	SmydA-5 / 35538	FlyBaseID:	FBgn0033061	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001260462.1	Gene:	dao / 34891	FlyBaseID:	FBgn0028862	Length:	882	Species:	Drosophila melanogaster

Alignment Length:	559	Identity:	109/559 - (19%)
Similarity:	175/559 - (31%)	Gaps:	212/559 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 LKVTQNIAAGQIVFIEEPLVVGPKWYLSDAD----KEASNVPCVGCYTPCRLGKHQCRRCRWPVC 118
            |..|:.:|...::|..|.:.:.|.......|    .:....||:.|..  ||..:..|:||:
  Fly   326 LHTTRAVAKNALIFESEAVAMVPSGNCRVCDYCGITQFIPFPCIYCSN--RLVVYCSRQCRF--- 385

  Fly   119 SAGCKH---ESMEC------SVLSLGS--GSPTRADARSLNDYFRGDALLV--LKCLL------- 163
                ||   .::||      ...|.|.  |.|     |.|...||   :|:  |..||
  Fly   386 ----KHAAIHAVECFGHQIELFESFGEVFGMP-----RLLQLAFR---MLITGLPELLGHCRKKP 438

  Fly   164 ------------LQRQSPTKWSALLEMQSHEEER--------------------KGTDLYEEAEK 196
                        ||.:....:||:|.::..:|||                    |.|..:::.||
  Fly   439 TLSKLWSAINGGLQERQDIAYSAVLRLERLKEERPTDTVIALALAAHILSIYLSKCTTFFDQLEK 503

  Fly   197 RVVT-----YLQKRFLC------RLKQTNPNLLTDCGPEMLHRLCGIIETNFMVIELPSGVELSG 250
            .:.|     ..:...||      .:.|.....||.|             .:|:   ||:.
  Fly   504 SLPTASRMSSAEWELLCAALLMRHIGQLRHRSLTAC-------------RSFV---LPAD----- 547

  Fly   251 LFRQACMMEHACQPNCDFQFDNKTQQVAVRAGCDLRKGDHLRITYTNILWGT--QLRQHHLRL-- 311
                    .|...|..:||                             ||..  :|::.||.|
  Fly   548 --------PHVFSPLNEFQ-----------------------------LWAAPMRLQEGHLHLLA 575

  Fly   312 ----TKHFS--------CR--CSRCLDPTEYGTYISALTCL------GDVNQTCGGT--HLPVDP 354
                ...:|        ||  ||..:.....|..::||..|      |..|...||.  .||.:.
  Fly   576 GEVAVVSYSVYPDTLNLCRHSCSSTICAKFSGRTVTALALLDLPAGSGIYNCFAGGNFQQLPREE 640

  Fly   355 -----LDENTQWKCDTCPMIVDGAYVAELQSHMTEQVEGL-LAGCPSANQVELLLARLTHMLHPN 413
                 |:...:..|:.|.:           :|..:|.... ...|.:.|.:|:..        ||
  Fly   641 RTKQLLESGIRCHCNACQL-----------THSDDQFHKFHRYRCDNPNCMEIFT--------PN 686

  Fly   414 HF-HTFNLKHTLIQLYGNEA--GLELGVLSNTQLERKLRLCGELYNVCRRLDPYSIKLAIYVTVI 475
            .. |..:|:..|.:.|....  |.:|.:..:         |||.    ::|:.:.......:...
  Fly   687 ALPHAPSLRWWLSEEYTQPEFNGADLIMCPH---------CGEY----QKLEWFWAFTTSLIDCE 738

  Fly   476 LIEVAHTLQEQARRAPAEGTSLLGLAQSRLREAHMVLEK 514
            |||....|.....||.   ..|:.|.:.::..|.::||:
  Fly   739 LIEERCKLYAAIERAE---NQLMDLHECKVALARLLLEQ 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-5	NP_610202.3	zf-MYND	7..43	CDD:280009
SmydA-5	NP_610202.3	SET	185..295	CDD:279228	19/140 (14%)
dao	NP_001260462.1	TPR_11	165..235	CDD:290150
		TPR repeat	200..235	CDD:276809
		TPR repeat	243..270	CDD:276809
		zf-MYND	355..395	CDD:280009	11/48 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45473065
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830