DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SmydA-5 and SmydA-9

DIOPT Version :9

Sequence 1:	NP_610202.3	Gene:	SmydA-5 / 35538	FlyBaseID:	FBgn0033061	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001285040.1	Gene:	SmydA-9 / 31859	FlyBaseID:	FBgn0030102	Length:	500	Species:	Drosophila melanogaster

Alignment Length:	564	Identity:	127/564 - (22%)
Similarity:	222/564 - (39%)	Gaps:	164/564 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 PFSEEQDA-EL------GRYLKVTQNIAAGQIVFIEEPLVVGPKWYLSDADKEASNVPCVGCYTP 102
            ||.::..| |:      ||.:..|:::..|:|:|.:.||::|    |:..::::.|. |..|...
  Fly    17 PFKDKDPAWEIGVSKIAGRGVVATRSLKRGEIIFRDSPLLIG----LAAHEEDSLNA-CSVCLKM 76

  Fly   103 CRLGKHQCRR-CRWPVCSAGCK---HESMECSVL-SLGSGSPTRADARSLNDYFRGDALLVLKCL 162
            ....:..||: |..||||...|   |:| :|.:. |.|...|..|::            ::::.|
  Fly    77 LPDTRFMCRQGCGLPVCSLCAKKKQHKS-DCDLFKSWGPNEPDVANS------------VIIRLL 128

  Fly   163 LLQRQ---SPTKWSALLEMQSHEEERKGTDLYEEAEKRVVTYLQKRFLCRLKQTNPNLLTDCGPE 224
            .:.|.   |..:...:..:|::.:....|::...|:      ..|.|     .|:..|:     |
  Fly   129 CVARAINLSKEQRDLIYCLQANLDNNHRTEVRNAAK------CFKNF-----PTDKKLI-----E 177

  Fly   225 MLHRLCGIIETNFMVIELPSGVELS-------------GLFRQACMMEHACQPNCDFQFDNKTQQ 276
            :::|...::.||        |.:.:             .|:....::.|.|.||..:.|:.||..
  Fly   178 IMNRTVAVLRTN--------GFDKTTDRTNDNQEFNYRALYPLFGVVNHDCIPNAYYTFEEKTNN 234

  Fly   277 VAVRAGCDLRKGDHLRITYTNILWGTQLRQHHLRLTKHFSCRCSRCLDPTEYGTYISALTCLGDV 341
            :.|||..|:.:|..:..|||.:..|...|...|::.|.|:|:||||.||||.|.:||.|.| .|.
  Fly   235 MIVRAAVDIPEGFEVTTTYTKLFTGNIARHLFLKMKKSFTCKCSRCSDPTEKGAFISGLYC-RDT 298

  Fly   342 NQTCGGTHLPVDPLDENTQWKCDTCPM------------IVDGAYVAELQS--------HMTEQV 386
            |  |.|..:|......:..|.|..|..            ...||..|::.|        ::.|:.
  Fly   299 N--CTGLVVPEITGLPHPNWNCLVCKQKSTHAQMMKSQDFASGAINAKVNSNSLRTLVQYLNEKS 361

  Fly   387 EGLLAGCPSANQVELLLARLTHMLHPNHFHTFNLKHTLIQLYGNEAGLELGVLSNTQLERKLRLC 451
            :..:   ||:|.|                 ..:.|.:::|                :|::....|
  Fly   362 DSFI---PSSNYV-----------------VIDAKMSVLQ----------------RLQQGREDC 390

  Fly   452 GELYNVCRRLDPYSIKLAIYVTVILIEVAHTLQEQARRAPAEGTSLLGLAQSRLREAHM--VLEK 514
            .|                        |:||..:.:..|...:....|||..|.|| .|:  :|.:
  Fly   391 SE------------------------ELAHNTRLRYSRDITQLMDKLGLGDSLLR-THLEELLRR 430

  Fly   515 EQESVAGKKLNE--------KLQMEIFECEKLILALAYNQDHEA 550
            |:|..|.:..:|        :||.:..|.:||:..|...|..::
  Fly   431 EEERRAKRLADEAEKQRKLAELQAKAAEADKLLEVLQKEQSEQS 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-5	NP_610202.3	zf-MYND	7..43	CDD:280009
SmydA-5	NP_610202.3	SET	185..295	CDD:279228	24/122 (20%)
SmydA-9	NP_001285040.1	SET	25..>66	CDD:295368	11/44 (25%)
SmydA-9	NP_001285040.1	SET	<216..253	CDD:279228	12/36 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45473053
Domainoid	1	1.000	54	1.000	Domainoid score	I11197
eggNOG	1	0.900	-	-		E2759_KOG2084
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D981799at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR46455
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2289
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.880