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Protein Alignment SmydA-5 and SMYD4

DIOPT Version :9

Sequence 1:	NP_610202.3	Gene:	SmydA-5 / 35538	FlyBaseID:	FBgn0033061	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_443160.2	Gene:	SMYD4 / 114826	HGNCID:	21067	Length:	804	Species:	Homo sapiens

Alignment Length:	596	Identity:	115/596 - (19%)
Similarity:	179/596 - (30%)	Gaps:	223/596 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ASQACTRCKMVRYCDREHQKQHWP-QHKRRCRPFSEEQDAELGRYL------------------- 58
            |:..|..|...:||.:|..:|.|. .|:..|         .||..|
Human   305 ATVPCDGCSYAKYCSQECLQQAWELYHRTEC---------PLGGLLLTLGVFCHIALRLTLLVGF 360

  Fly    59 --------KVTQNIAAGQIVFIEEPLVVGPKWY-LSDADKEASNV--PCVGC------------- 99
                    |:...|:...|...|....|....| |.:::|..:.|  |..||
Human   361 EDVRKIITKLCDKISNKDICLPESNNQVKTLNYGLGESEKNGNIVETPIPGCDINGKYENNYNAV 425

  Fly   100 -----YTPCRLGKHQ--CRRCRWPVCSAGCKHESMECSVLSLGSGSPTRADARSLNDYFRGDALL 157
                 :|.....:|:  |..|    .||.|:  .:|.:.|   ...||.....|..
Human   426 FNLLPHTENHSPEHKFLCALC----VSALCR--QLEAASL---QAIPTERIVNSSQ--------- 472

  Fly   158 VLKCLLLQRQSP--TKWSA-----LLEMQSHEEERKGTDLYEEAEKRVVTYLQKRFLCRLKQTNP 215
             ||..:.....|  |.|..     :|::|.:.:.                      :..::.|.|
Human   473 -LKAAVTPELCPDVTIWGVAMLRHMLQLQCNAQA----------------------MTTIQHTGP 514

  Fly   216 NLLTDCGPEMLHRLCGIIETNFMVIELPSGVELSGLFRQACMMEHACQPNCDFQFDNKTQQVAVR 280
            .              |.|.|:...:.|.:|:     |....::.|:|.||....|.:..  ..:|
Human   515 K--------------GSIVTDSRQVRLATGI-----FPVISLLNHSCSPNTSVSFISTV--ATIR 558

  Fly   281 AGCDLRKGDHLRITY--TNILWGTQLRQHHLRLTKHFSCRCSRCLDPTE-----YGTYISALTCL 338
            |...:|||..:...|  .....|...||..||....|.|.|..|  .||     .|....|..|
Human   559 ASQRIRKGQEILHCYGPHKSRMGVAERQQKLRSQYFFDCACPAC--QTEAHRMAAGPRWEAFCC- 620

  Fly   339 GDVNQTCGGTHLPVDPLDENTQWKCD--TCPMIVDGAYVAELQSHMTEQVEGLLAGCPSANQVEL 401
                .:||.      |:..:...:|.  :|      |..|..:.|:..:::.|        |.::
Human   621 ----NSCGA------PMQGDDVLRCGSRSC------AESAVSRDHLVSRLQDL--------QQQV 661

  Fly   402 LLARLTHMLHPNHFHTFNLKHTLIQLYGNEAGLELGV--LSNTQLERKLRLCGE----------L 454
            .:|                     |....:..||..|  ||..|.:.:..|..|          |
Human   662 RVA---------------------QKLLRDGELERAVQRLSGCQRDAESFLWAEHAVVGEIADGL 705

  Fly   455 YNVCRRLDPYS-----IKLAIYVTVILIEVAHTLQEQARRAPAE---GTSLLGLAQ-----SRLR 506
            ...|..|..:.     ::.::||    :||.|        .|:.   |..|..|||     ..:.
Human   706 ARACAALGDWQKSATHLQRSLYV----VEVRH--------GPSSVEMGHELFKLAQIFFNGFAVP 758

  Fly   507 EAHMVLEKEQE 517
            ||...::|.:|
Human   759 EALSTIQKAEE 769

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.