DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)k09848 and Wdr74

DIOPT Version :9

Sequence 1:	NP_001188867.1	Gene:	l(2)k09848 / 35536	FlyBaseID:	FBgn0284246	Length:	419	Species:	Drosophila melanogaster
Sequence 2:	XP_006231061.1	Gene:	Wdr74 / 690229	RGDID:	1582881	Length:	385	Species:	Rattus norvegicus

Alignment Length:	433	Identity:	128/433 - (29%)
Similarity:	193/433 - (44%)	Gaps:	72/433 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKWTTANTKHVNYTAKHELYVGTHTGSFKHL----VPASEKTPYGQSNLSDLCALDKDSRVTSLA 61
            |..|:|...||        :|||.||..|.:    ..|:..||.||..        ::..|.:|.
  Rat     1 MAATSARWNHV--------WVGTETGILKGVNLQRKLAANFTPSGQPR--------REEAVNALC 49

  Fly    62 FGNDDQTEILLGRAKDAVEIHSFTEKG--HSRNTVSFNAAPIVGLARYND-KLIAGIGNGEIQS- 122
            :|...:|:||:|.|...|. |...|:|  .|:...........|||:.:| .||..:.:|.::.
  Rat    50 WGTGGETQILVGCADRTVR-HFNAEEGTFQSQRYCPGGEGTFRGLAQADDGTLITCVDSGILRVW 113

  Fly   123 LELEANDESEPVV-IATGDQMDHLRQCAQVKSIVATGGKERQNNLKVYDLNADGKQIFTSKNLPN 186
            .|.:....|:|:: :..|..:..:||......:|||.|||  |.|||:||....:.:|.:||:.|
  Rat   114 CENDKEASSDPLLELKVGPGVCRMRQDPTHTHVVATCGKE--NALKVWDLQGSEEPVFRAKNVRN 176

  Fly   187 DYLQLEVPVWDSDIGFVDGPSVLATCSRTGY--VRIYD-TRKQRRPVACFASEEHGMSFTTLVAK 248
            |:|.|.||:||.||.|:.|...|.||  |||  ||||| ...|||||......|:.::..||..:
  Rat   177 DWLDLRVPIWDQDIQFLPGSQKLVTC--TGYHQVRIYDPASPQRRPVLEATYGEYPLTAMTLTPE 239

  Fly   249 GNFIYTGTTMGALKAFDTRRMKTHVHTYKGFTGGISDLHLDATGRFLSSASLDRYVRIHD-SETT 312
            ||.:..|.|.|.|...|.|:.:. :...||..|.:..|....:...|:|..|||.:|||. ....
  Rat   240 GNSVIVGNTHGQLAEIDFRQGRL-LGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIRNPR 303

  Fly   313 VLLYQCYVKSKATKILIRPFENEARVTEEPEEVADLQMDRNVSENKSVNATSVDNEYEDMFDQMP 377
            .|.::.|:||:...:|:...:|.....:||:|                                |
  Rat   304 GLEHKVYLKSQLNCLLLSGRDNWEDEPQEPQE--------------------------------P 336

  Fly   378 T-VGDSDNESEEEMSNI----KLSKADLKRRSSEKSLKNKKKK 415
            . |...|.|::|..:::    |....||.::......:.|||:
  Rat   337 NLVPPEDTETDELWASLEAAAKRKLPDLDQKQGALQRRKKKKR 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)k09848	NP_001188867.1	WD40	36..>327	CDD:225201	100/299 (33%)
		WD40	55..318	CDD:295369	93/271 (34%)
		WD40 repeat	146..184	CDD:293791	16/37 (43%)
		WD40 repeat	240..277	CDD:293791	10/36 (28%)
		WD40 repeat	283..309	CDD:293791	9/26 (35%)
Wdr74	XP_006231061.1	WD40	45..303	CDD:421866	92/263 (35%)
		WD40 repeat	91..128	CDD:293791	10/36 (28%)
		WD40 repeat	134..172	CDD:293791	15/39 (38%)
		WD40 repeat	186..225	CDD:293791	22/40 (55%)
		WD40 repeat	231..267	CDD:293791	10/36 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347809
Domainoid	1	1.000	112	1.000	Domainoid score	I6084
eggNOG	1	0.900	-	-		E1_KOG3881
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I4489
OMA	1	1.010	-	-		QHG56769
OrthoDB	1	1.010	-	-		D1439033at2759
OrthoFinder	1	1.000	-	-		FOG0004298
OrthoInspector	1	1.000	-	-		oto98419
orthoMCL	1	0.900	-	-		OOG6_103653
Panther	1	1.100	-	-	LDO	PTHR16038
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3557
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.810