DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)k09848 and wdr74

DIOPT Version :9

Sequence 1:	NP_001188867.1	Gene:	l(2)k09848 / 35536	FlyBaseID:	FBgn0284246	Length:	419	Species:	Drosophila melanogaster
Sequence 2:	NP_001070031.1	Gene:	wdr74 / 558996	ZFINID:	ZDB-GENE-060929-1138	Length:	375	Species:	Danio rerio

Alignment Length:	392	Identity:	110/392 - (28%)
Similarity:	189/392 - (48%)	Gaps:	33/392 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LYVGTHTGSFKHLVPASEKTPYGQSNLSDLCALDKDSRVTSLAFGNDDQTEILLGRAKDAVEIHS 83
            :::|:.||..|. |...:|..:   |..::..|.:|..|..:|:|:..::|:|||.....|:..|
Zfish    10 IWLGSETGILKG-VSLRKKQAF---NFCEMSCLSRDQEVCVMAWGDPYESELLLGSVNGTVKTFS 70

  Fly    84 FTEKG---HSRNTVSFNAAPIVGLARYNDKLIAGIGNGEIQSLELEANDESEPVVIATGDQMDHL 145
             |:||   .::.....:.....|||..:..:|..:.:|   .|::.....::.|.:..|..:..:
Zfish    71 -TDKGIFTATKECGDPSQGKFTGLAVTDSSMITCVESG---LLKVWKEGSTDTVEVNVGKDICKM 131

  Fly   146 RQCAQVKSIVATGGKERQNNLKVYDLNADGKQIFTSKNLPNDYLQLEVPVWDSDIGFVDGPSVLA 210
            ||....:..|||||||  |.|||:||....|.|||:||:.:|:|::.||||..||.|:.....:.
Zfish   132 RQNQSQRHHVATGGKE--NPLKVWDLEKPDKPIFTAKNVAHDWLEMRVPVWVRDISFIADSDKIV 194

  Fly   211 TCSRTGYVRIYD-TRKQRRPVACFASEEHGMSFTTLVAKGNFIYTGTTMGALKAFDTRRMKTHVH 274
            ||:....||:|| :..|||||......|:.::..:|.|..:.:..|.|.|.|...|.|:.... .
Zfish   195 TCTGHHKVRVYDPSTPQRRPVLEADFGEYPLTALSLPASQDAVVVGNTHGELAILDLRKGLVR-G 258

  Fly   275 TYKGFTGGISDLHLDATGRFLSSASLDRYVRIHDSETTVLLYQCYVKSKATKILIRPFENEARVT 339
            .:||..|.:..|....:...::|..|||::|:|..|...|.::.|:||:...:|:     .:|..
Zfish   259 CFKGLAGAVRGLQCHPSLPLVASCGLDRFLRVHSLEDRSLQHKVYLKSRLNCVLL-----SSRDL 318

  Fly   340 EEPEEVADLQMDRNVSENKSVNATSVDNEYEDMFDQMPTVGDSDNESEEEMSNIKLSKADLKRRS 404
            |...:..|      |.|.|:       .|.::::|.|.||.:...:...|.....::.||.|::.
Zfish   319 ESSSDSGD------VEEVKA-------EEEDEVWDNMETVTEKTKKRAAEKDEAAVTGADGKKKR 370

  Fly   405 SE 406
            .:
Zfish   371 KQ 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)k09848	NP_001188867.1	WD40	36..>327	CDD:225201	89/294 (30%)
		WD40	55..318	CDD:295369	82/266 (31%)
		WD40 repeat	146..184	CDD:293791	20/37 (54%)
		WD40 repeat	240..277	CDD:293791	8/36 (22%)
		WD40 repeat	283..309	CDD:293791	7/25 (28%)
wdr74	NP_001070031.1	WD40 repeat	44..82	CDD:293791	12/38 (32%)
		WD40	<52..325	CDD:225201	85/284 (30%)
		WD40 repeat	125..166	CDD:293791	20/42 (48%)
		WD40	137..>300	CDD:295369	60/165 (36%)
		WD40 repeat	182..219	CDD:293791	14/36 (39%)
		WD40 repeat	225..261	CDD:293791	8/36 (22%)
		WD40 repeat	267..309	CDD:293791	12/41 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589395
Domainoid	1	1.000	139	1.000	Domainoid score	I4732
eggNOG	1	0.900	-	-		E1_KOG3881
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	140	1.000	Inparanoid score	I4485
OMA	1	1.010	-	-		QHG56769
OrthoDB	1	1.010	-	-		D1439033at2759
OrthoFinder	1	1.000	-	-		FOG0004298
OrthoInspector	1	1.000	-	-		oto40608
orthoMCL	1	0.900	-	-		OOG6_103653
Panther	1	1.100	-	-	LDO	PTHR16038
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R841
SonicParanoid	1	1.000	-	-		X3557
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800