DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)k09848 and T06E6.1

DIOPT Version :9

Sequence 1:	NP_001188867.1	Gene:	l(2)k09848 / 35536	FlyBaseID:	FBgn0284246	Length:	419	Species:	Drosophila melanogaster
Sequence 2:	NP_506824.1	Gene:	T06E6.1 / 180039	WormBaseID:	WBGene00011538	Length:	431	Species:	Caenorhabditis elegans

Alignment Length:	415	Identity:	116/415 - (27%)
Similarity:	212/415 - (51%)	Gaps:	31/415 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ELYVGTHTGSFKHLVPASEKTPYGQSNLSDLCALD-KDSRVTSLAFGNDDQTEILLGRAKDAVEI 81
            :.|||..||:.|..: ..|.|   ..||:::.:|| |...:||:.:.::.|||||:.|....:::
Worm     2 DCYVGATTGALKGAI-LKENT---FQNLNEIKSLDPKSDEITSMIWNDEQQTEILIARVNRDLQL 62

  Fly    82 HSFTEKG-HSRNTVSFNAAPIVGLARYNDKLIAGIGNGEIQSLELEANDESEPVVIA---TGDQM 142
            ....|.. .|..||:....||.||.:.::|::..:.:||:|..    ||:||  :::   ||..:
Worm    63 LGIEENELVSILTVTGGTGPIKGLHKADEKIVTCVESGELQIW----NDKSE--ILSEWKTGPGV 121

  Fly   143 DHLRQCAQVKSIVATGGKERQNNLKVYDLNADGKQIFTSKNLPNDYLQLEVPVWDSDIGFVDGPS 207
            ..:|...:...|| |||  .:|.||.::|.. |:|.:::||:|.|.|.||:|:..:|..|:.|.:
Worm   122 AVMRGSTEKPEIV-TGG--MKNLLKTWNLET-GQQTWSAKNVPPDMLGLEIPIMITDARFIPGQN 182

  Fly   208 VLATCSRTGYVRIYDTRKQRRPVACFASEEHGMSFTTLVAKGNFIYTGTTMGALKAFDTRRMKTH 272
            .:...::...:|:||.|.|||||......|:.:..|:|..|.|.|....::|.:..||.|.....
Worm   183 TILEATKLHEMRLYDPRAQRRPVKKIPFMENPIMCTSLTYKTNQILAANSIGEMGLFDLRSKVHP 247

  Fly   273 VHTYKGFTGGISDLHLDATGRFLSSASLDRYVRIHDSETTVLLYQCYVKSKATKILIR------- 330
            :..:||..|.|..:....|....:|..:||::|:||.::..|:::.|.|::..::|:|
Worm   248 MCKFKGQAGSIRSITAHPTLPLAASVGIDRFLRVHDLQSRKLIHKIYCKTRLNRVLLRDNLSILN 312

  Fly   331 ---PFENEARVTEEPEEVADLQMDRNVSENKSVNATSVDNEYEDMFDQMPTVGDSDNESEEEMSN 392
               | .::..:.|:..|..::..|...|||:.........|.:|::..|..|..:...|::::..
Worm   313 DKKP-ASKKEINEDETEYGNMTKDGYRSENEDDEDDDDVIEEDDVWGVMEPVKRAKKSSDDDVEE 376

  Fly   393 IKLSKADLKRRSSEKSLKNKKKKVV 417
            |:::...: ...|:.|.|.|:|.|:
Worm   377 IQITSETI-AVPSKNSQKLKRKNVL 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)k09848	NP_001188867.1	WD40	36..>327	CDD:225201	89/295 (30%)
		WD40	55..318	CDD:295369	80/266 (30%)
		WD40 repeat	146..184	CDD:293791	13/37 (35%)
		WD40 repeat	240..277	CDD:293791	9/36 (25%)
		WD40 repeat	283..309	CDD:293791	7/25 (28%)
T06E6.1	NP_506824.1	WD40	<22..286	CDD:225201	84/273 (31%)
		WD40	27..293	CDD:295369	83/275 (30%)
		WD40 repeat	38..78	CDD:293791	12/39 (31%)
		WD40 repeat	121..160	CDD:293791	14/42 (33%)
		WD40 repeat	173..209	CDD:293791	12/35 (34%)
		WD40 repeat	215..252	CDD:293791	9/36 (25%)
		WD40 repeat	258..297	CDD:293791	10/38 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163387
Domainoid	1	1.000	149	1.000	Domainoid score	I2710
eggNOG	1	0.900	-	-		E1_KOG3881
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	150	1.000	Inparanoid score	I2974
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56769
OrthoDB	1	1.010	-	-		D1439033at2759
OrthoFinder	1	1.000	-	-		FOG0004298
OrthoInspector	1	1.000	-	-		oto20315
orthoMCL	1	0.900	-	-		OOG6_103653
Panther	1	1.100	-	-	LDO	PTHR16038
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R841
SonicParanoid	1	1.000	-	-		X3557
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800