DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCHa2-R and GPR37L1

DIOPT Version :9

Sequence 1:	NP_001356958.1	Gene:	CCHa2-R / 35535	FlyBaseID:	FBgn0033058	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_004758.3	Gene:	GPR37L1 / 9283	HGNCID:	14923	Length:	481	Species:	Homo sapiens

Alignment Length:	408	Identity:	94/408 - (23%)
Similarity:	174/408 - (42%)	Gaps:	48/408 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LADSDGNGANDSGLLATGQGLEQEQEGLALDMGHNASADGGIV----PYVPVLDRP-ETYIVTVL 75
            |..:..|...|.|...:||.|.          |:...|.|..:    |..||.:.. ..|.:.:|
Human    82 LVATSPNPGKDGGTPDSGQELR----------GNLTGAPGQRLQIQNPLYPVTESSYSAYAIMLL 136

  Fly    76 YTLIFIVGVLGNGTLVIIFFRHRSMRNIPNTYILSLALADLLVILVCVPVATIVYTQESWPFERN 140
            ..::|.||::||.:::.|.:....:::..|:.:.||||.|.||:..|:|:  :::.:.:  .:|.
Human   137 ALVVFAVGIVGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFFCLPI--VIFNEIT--KQRL 197

  Fly   141 M----CRISEFFKDISIGVSVFTLTALSGERYCAIVNPLRKLQTKPLTVFTAVM-----IWILAI 196
            :    ||...|.:..|:||:.|:|.||..:|:....:.|.|:  :|:....:::     ||:.::
Human   198 LGDVSCRAVPFMEVSSLGVTTFSLCALGIDRFHVATSTLPKV--RPIERCQSILAKLAVIWVGSM 260

  Fly   197 LLGMPSVLFSDIKSYPVFTATGNMTIEVCSPFRD-PE--YAKFMVAGKALV------YYLLPLSI 252
            .|.:|.:|...:...|..| .|.:...:..|... ||  |:..|....|.:      |:.||:
Human   261 TLAVPELLLWQLAQEPAPT-MGTLDSCIMKPSASLPESLYSLVMTYQNARMWWYFGCYFCLPI-- 322

  Fly   253 IGALYIMMAKRLHMSARNMPGEQQSMQSRTQARARLHVARMVVAFVVVFFICFFPYHVFELWYHF 317
               |:.:..:.:....|..||.:...::....:....:...||...||:..|..|.:|..:...:
Human   323 ---LFTVTCQLVTWRVRGPPGRKSECRASKHEQCESQLNSTVVGLTVVYAFCTLPENVCNIVVAY 384

  Fly   318 YPTAEEDFDEFWNVLRIVGFCTSFLNSCVNPVALYCVSGVFRQHFNRYLCCICVKRQPHLRQHST 382
            ..|  |...:..::|.::...::|....:.||.|.|:.....|.|....||.|.:......:.|.
Human   385 LST--ELTRQTLDLLGLINQFSTFFKGAITPVLLLCICRPLGQAFLDCCCCCCCEECGGASEASA 447

  Fly   383 ATGMMDNTSVMSMRRSTY 400
            |.| .||.....:..|.|
Human   448 ANG-SDNKLKTEVSSSIY 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCHa2-R	NP_001356958.1	7tmA_Bombesin_R-like	70..362	CDD:320593	70/309 (23%)
		TM helix 1	71..97	CDD:320593	7/25 (28%)
		TM helix 2	104..130	CDD:320593	10/25 (40%)
		TM helix 3	142..172	CDD:320593	11/29 (38%)
		TM helix 4	182..202	CDD:320593	4/24 (17%)
		TM helix 5	234..259	CDD:320593	6/30 (20%)
		TM helix 6	285..315	CDD:320593	7/29 (24%)
		TM helix 7	330..355	CDD:320593	6/24 (25%)
GPR37L1	NP_004758.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..58
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	70..108		8/35 (23%)
		7tm_1	147..397	CDD:278431	58/263 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910