Protein Alignment CCHa2-R and CCKBR

DIOPT Version :10

• Sequence 1: NP_001356958.1
• Gene: CCHa2-R / 35535
• FlyBaseID: FBgn0033058
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001350481.1
• Gene: CCKBR / 887
• HGNCID: 1571
• Length: 516
• Species: Homo sapiens
• Alignment Length: 473
• Identity: 99/473 - (20%)
• Similarity: 168/473 - (35%)
• Gaps: 158/473 - (33%)

  Fly    68 ETYIVTVLYTLIFIVGVLGNGTLVIIFFRHRSMRNIPNTYILSLALADLLVILVCVPVATIVYTQ 132
            |..|...||.:||::.|.||..::::....|.:|.:.|.::||||::|||:.:.|:|...:....
Human    53 ELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLM 117

  Fly   133 ESWPFERNMCRISEFFKDISIGVSVFTLTALSGERYCAIVNPL--RKLQTKPLTVFTAVMIWILA 195
            .::.|...:|:...:...:|:.||..:|.|::.|||.||..||  |..||:.......|..|:|:
Human   118 GTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLS 182

  Fly   196 ILLGMPSVLFSDIKSYPVFTA---TGNMTIEVCSPFRDPEYAKFMVAGKALVYYLLPLSIIGALY 257
            .||.:|         |||:|.   .|...::....:......:.......|:.:.:|..::...|
Human   183 GLLMVP---------YPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAY 238

  Fly   258 IMMAKRLHMSAR-----------------NMPG-----EQ------------------------- 275
            .::::.|::..|                 .:||     ||
Human   239 GLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGGAGPREQNLGEAELWRATGPAGVGGTEMKVRV 303

  Fly   276 -------------------------------------------------------------QSMQ 279
                                                                         |..:
Human   304 RRKLEMELSWERRSGGDWAGDWGDSPFSLTAHPLCSGAVHQNGRCRPETGAVGEDSDGCYVQLPR 368

  Fly   280 SR-------------------TQAR--ARLHVARMVVAFVVVFFICFFPYHVFELWYHF-YPTAE 322
            ||                   |||:  |:..|.||::..||:||:|:.|.:....|..| .|.|.
Human   369 SRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAH 433

  Fly   323 EDFD----EFWNVLRIVGFCTSFLNSCVNPVALYC-VSGVFRQHFNRYLCCICVKRQPHLRQHST 382
            ....    .|.::|       |:.::||||: :|| :...|||.... .|..|..|.|..|..:.
Human   434 RALSGAPISFIHLL-------SYASACVNPL-VYCFMHRRFRQACLE-TCARCCPRPPRARPRAL 489

  Fly   383 ATGMMDNTSVMSMRRSTY 400
            ........|:.|:.|.:|
Human   490 PDEDPPTPSIASLSRLSY 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCHa2-R	NP_001356958.1	7tmA_Bombesin_R-like	70..362	CDD:320593	89/431 (21%)
		TM helix 1	71..97	CDD:320593	8/25 (32%)
		TM helix 2	104..130	CDD:320593	10/25 (40%)
		TM helix 3	142..172	CDD:320593	10/29 (34%)
		TM helix 4	182..202	CDD:320593	5/19 (26%)
		TM helix 5	234..259	CDD:320593	3/24 (13%)
		TM helix 6	285..315	CDD:320593	10/31 (32%)
		TM helix 7	330..355	CDD:320593	8/25 (32%)
CCKBR	NP_001350481.1	7tm_GPCRs	55..470	CDD:475119	89/431 (21%)
		TM helix 1	57..81	CDD:320645	7/23 (30%)
		TM helix 2	90..112	CDD:320645	10/21 (48%)
		TM helix 3	128..150	CDD:320645	5/21 (24%)
		TM helix 4	173..189	CDD:320645	6/24 (25%)
		TM helix 5	216..239	CDD:320645	2/22 (9%)
		TM helix 6	401..423	CDD:320645	8/21 (38%)
		TM helix 7	438..463	CDD:320645	9/32 (28%)