DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCHa2-R and ednrb

DIOPT Version :9

Sequence 1:	NP_001356958.1	Gene:	CCHa2-R / 35535	FlyBaseID:	FBgn0033058	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_012812722.1	Gene:	ednrb / 779931	XenbaseID:	XB-GENE-963709	Length:	433	Species:	Xenopus tropicalis

Alignment Length:	318	Identity:	98/318 - (30%)
Similarity:	162/318 - (50%)	Gaps:	23/318 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 YIVTVLYTLIFIVGVLGNGTLVIIFFRHRSMRNIPNTYILSLALADLLVILVCVPVATIVYTQES 134
            ||.:|:..||||||:.||..|:.|.:::..|||.|...|.||||.|||.|::.:|:.|.....:.
Frog    94 YITSVISCLIFIVGITGNSALLRIIYKNTCMRNGPYILIASLALGDLLHIIIDIPITTYKLLAQD 158

  Fly   135 WPFERNMCRISEFFKDISIGVSVFTLTALSGERYCAIVNPLRKLQTKPLTVFTAV---MIWILAI 196
            |||...:|::..|.:..::|:::.:|.|||.:||.|:.: ...::|..::.:.||   .||:::.
Frog   159 WPFGVEICKLVPFLQKATVGITMLSLCALSIDRYRAVAS-WAHVKTTGVSKWIAVEIAFIWLVSS 222

  Fly   197 LLGMPSVLFSDIKSYPVFTATGNMTIEVC--SPFRDPEYAKFMVAGKAL----VYYLLPLSIIGA 255
            .|.:|.|:..|:    :.|......::.|  .|.:...:.:|....|.:    .|:.|||.:...
Frog   223 ALAIPEVIGYDL----IVTNYRGELLQTCMLHPIQTSAFMRFYKTYKDMWLFSFYFCLPLVLTAV 283

  Fly   256 LYIMMAKRLHMSARNMPGEQQSMQSRTQARARLHVARMVVAFVVVFFICFFPYHVFE-LWYHFYP 319
            .|.:|...|......|     ::......|.|..:|:||...|:|:.:|:.|.|:.. |.:.||.
Frog   284 FYTLMTFELFRKKNGM-----ALAITDTLRQRREIAKMVFYLVLVYAVCWLPLHLSRILKFTFYD 343

  Fly   320 TAEE---DFDEFWNVLRIVGFCTSFLNSCVNPVALYCVSGVFRQHFNRYLCCICVKRQ 374
            ..:.   ||..|..:|..:|...:.||||:||:|||.||..||..|...|.|.|..::
Frog   344 EKDAKRCDFLSFLLLLDYIGINMANLNSCINPIALYLVSTKFRNCFKSCLFCCCQSKE 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCHa2-R	NP_001356958.1	7tmA_Bombesin_R-like	70..362	CDD:320593	94/304 (31%)
		TM helix 1	71..97	CDD:320593	12/25 (48%)
		TM helix 2	104..130	CDD:320593	12/25 (48%)
		TM helix 3	142..172	CDD:320593	10/29 (34%)
		TM helix 4	182..202	CDD:320593	5/22 (23%)
		TM helix 5	234..259	CDD:320593	7/28 (25%)
		TM helix 6	285..315	CDD:320593	11/30 (37%)
		TM helix 7	330..355	CDD:320593	11/24 (46%)
ednrb	XP_012812722.1	7tmA_ET-BR	94..389	CDD:320642	94/304 (31%)
		TM helix 1	95..121	CDD:320642	12/25 (48%)
		TM helix 2	128..154	CDD:320642	12/25 (48%)
		TM helix 3	166..196	CDD:320642	10/29 (34%)
		TM helix 4	208..228	CDD:320642	5/19 (26%)
		TM helix 5	262..287	CDD:320642	6/24 (25%)
		TM helix 6	308..338	CDD:320642	10/29 (34%)
		TM helix 7	357..382	CDD:320642	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910