DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCHa2-R and tacr1b

DIOPT Version :9

Sequence 1:	NP_001356958.1	Gene:	CCHa2-R / 35535	FlyBaseID:	FBgn0033058	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001268728.1	Gene:	tacr1b / 564017	ZFINID:	ZDB-GENE-091117-17	Length:	412	Species:	Danio rerio

Alignment Length:	397	Identity:	109/397 - (27%)
Similarity:	181/397 - (45%)	Gaps:	52/397 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 NASADGGIVPYVPVLD---------RPETYIV--TVLYTLIFIVGVLGNGTLVIIFFRHRSMRNI 103
            |:|||.|... .||.|         :|...||  .:.|..|.:|.|:||.|::.|...|:.||.:
Zfish    10 NSSADNGSAG-SPVNDTEVFGNQFVQPVWQIVLWAIAYCTIVLVSVVGNITVIWIILAHKRMRTV 73

  Fly   104 PNTYILSLALADLLVILVCVPVATIVYTQESWPFERNMCRISEFFKDISIGVSVFTLTALSGERY 168
            .|.::::||.|:..:......:..|......|.|....||...||...::..|::::||::.:||
Zfish    74 TNYFLVNLAFAEASMSAFNTVINFIYAVHNEWYFGLVYCRFHNFFPIAAVFASIYSMTAIALDRY 138

  Fly   169 CAIVNPLRKLQTKPLTVFTAVMIWILAILLGMPSVLFSDIKSYPVFTATGNMTIEVCSPFRDPEY 233
            .||::||::..:...|.....:||.||::|..|...||.....|     |.:   ||. ...|||
Zfish   139 MAIIHPLQQRLSSAETKLVVCVIWALALMLAFPQYYFSSTAQLP-----GRV---VCY-INWPEY 194

  Fly   234 A------KFMVAGKALVYYLLPLSIIGALYIMMAKRLHMSARNMPGEQQSMQSRTQARARLHVAR 292
            :      .:.|....|:|: |||.::|..|:::.  ..:.|..:||: .|.:.|.|..|:..|.:
Zfish   195 SMWDFQKTYYVCVVVLIYF-LPLLVMGCAYLVVG--CFLWASEIPGD-SSDRYREQLIAKRKVVK 255

  Fly   293 MVVAFVVVFFICFFPYHVFELWYHFYPTAEEDFDEFWNVLRIVGFCTSFLNSCV-NPVALYC-VS 355
            |::..|..|..|:.||||:.:.:.|.|..   |:|.:.....:|.....::|.: ||: :|| ::
Zfish   256 MMIVVVCTFATCWLPYHVYFIVHQFLPHL---FEERYIQQVYLGIMWLAMSSTMYNPI-IYCLLN 316

  Fly   356 GVFRQHFNR-YLCCICVKRQPHLRQHSTATGMMDNTSVMSMRRSTYVGGTAGNLRASLHRNSNHG 419
            ..||..|.: :..|.||.:           |..:...:.|.|   |:...|...|||....:...
Zfish   317 DRFRAGFQQAFSWCPCVPQ-----------GSYEGLELKSTR---YLQTQASIFRASRMETTVST 367

  Fly   420 VGGAGGG 426
            |...|.|
Zfish   368 VMPTGDG 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCHa2-R	NP_001356958.1	7tmA_Bombesin_R-like	70..362	CDD:320593	85/301 (28%)
		TM helix 1	71..97	CDD:320593	10/27 (37%)
		TM helix 2	104..130	CDD:320593	5/25 (20%)
		TM helix 3	142..172	CDD:320593	10/29 (34%)
		TM helix 4	182..202	CDD:320593	6/19 (32%)
		TM helix 5	234..259	CDD:320593	8/30 (27%)
		TM helix 6	285..315	CDD:320593	10/29 (34%)
		TM helix 7	330..355	CDD:320593	6/26 (23%)
tacr1b	NP_001268728.1	7tm_4	48..>222	CDD:304433	53/183 (29%)
tacr1b	NP_001268728.1	7tm_1	56..312	CDD:278431	75/272 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910