DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCHa2-R and Ednrb

DIOPT Version :9

Sequence 1:	NP_001356958.1	Gene:	CCHa2-R / 35535	FlyBaseID:	FBgn0033058	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_059029.1	Gene:	Ednrb / 50672	RGDID:	2536	Length:	442	Species:	Rattus norvegicus

Alignment Length:	356	Identity:	109/356 - (30%)
Similarity:	177/356 - (49%)	Gaps:	46/356 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 MGHNASAD---GGIVPYVP------------VLDRPETYIVTVLYTLIFIVGVLGNGTLVIIFFR 96
            |..:|.|:   ||.|..||            .:::...||.|::..|:|::|::||.||:.|.::
  Rat    64 MRSSAPAEVTKGGRVAGVPPRSFPPPCQRKIEINKTFKYINTIVSCLVFVLGIIGNSTLLRIIYK 128

  Fly    97 HRSMRNIPNTYILSLALADLLVILVCVPVATIVYTQESWPFERNMCRISEFFKDISIGVSVFTLT 161
            ::.|||.||..|.||||.|||.|::.:|:.........|||...||::..|.:..|:|::|.:|.
  Rat   129 NKCMRNGPNILIASLALGDLLHIIIDIPINAYKLLAGDWPFGAEMCKLVPFIQKASVGITVLSLC 193

  Fly   162 ALSGERYCAIV--NPLRKLQTKPLTVFTAVMIWILAILLGMP-----SVLFSDIKSYPVFTATGN 219
            |||.:||.|:.  :.::.:.....|....|:||:::::|.:|     .|:.||.|..|
  Rat   194 ALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDVITSDYKGKP------- 251

  Fly   220 MTIEVC--SPFRDPEYAKFMVAGK----ALVYYLLPLSIIGALYIMMAKRLHMSARNMPGEQQSM 278
              :.||  :||:...:.:|....|    ...|:.|||:|....|.:|...:   .|...|.|.::
  Rat   252 --LRVCMLNPFQKTAFMQFYKTAKDWWLFSFYFCLPLAITAIFYTLMTCEM---LRKKSGMQIAL 311

  Fly   279 QSRTQARARLHVARMVVAFVVVFFICFFPYH---VFELWYHFYPTAEE-DFDEFWNVLRIVGFCT 339
            ..  ..:.|..||:.|...|:||.:|:.|.|   :.:|..:.....:. :...|..||..:|...
  Rat   312 ND--HLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQSNPQRCELLSFLLVLDYIGINM 374

  Fly   340 SFLNSCVNPVALYCVSGVFRQHFNRYLCCIC 370
            :.||||:||:|||.||..|:..|...|||.|
  Rat   375 ASLNSCINPIALYLVSKRFKNCFKSCLCCWC 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCHa2-R	NP_001356958.1	7tmA_Bombesin_R-like	70..362	CDD:320593	96/308 (31%)
		TM helix 1	71..97	CDD:320593	10/25 (40%)
		TM helix 2	104..130	CDD:320593	12/25 (48%)
		TM helix 3	142..172	CDD:320593	12/29 (41%)
		TM helix 4	182..202	CDD:320593	6/24 (25%)
		TM helix 5	234..259	CDD:320593	8/28 (29%)
		TM helix 6	285..315	CDD:320593	11/32 (34%)
		TM helix 7	330..355	CDD:320593	12/24 (50%)
Ednrb	NP_059029.1	7tmA_ET-BR	102..397	CDD:320642	96/308 (31%)
		TM helix 1	104..128	CDD:320642	9/23 (39%)
		TM helix 2	137..159	CDD:320642	11/21 (52%)
		TM helix 3	175..197	CDD:320642	7/21 (33%)
		TM helix 4	220..236	CDD:320642	4/15 (27%)
		TM helix 5	271..294	CDD:320642	6/22 (27%)
		TM helix 6	322..344	CDD:320642	8/21 (38%)
		TM helix 7	365..390	CDD:320642	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910