Protein Alignment CCHa2-R and OPRD1

DIOPT Version :10

• Sequence 1: NP_001356958.1
• Gene: CCHa2-R / 35535
• FlyBaseID: FBgn0033058
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_000902.3
• Gene: OPRD1 / 4985
• HGNCID: 8153
• Length: 372
• Species: Homo sapiens
• Alignment Length: 407
• Identity: 100/407 - (24%)
• Similarity: 168/407 - (41%)
• Gaps: 88/407 - (21%)

  Fly    12 LAARLADSDGNGANDSGLLATGQGLEQEQEGLALDMGHNASADGGIVPYVPVLDRPETYIVTVLY 76
            |.|..:|:..:....:|..|:|....:....|||.:.                       :|.||
Human    15 LFANASDAYPSACPSAGANASGPPGARSASSLALAIA-----------------------ITALY 56

  Fly    77 TLIFIVGVLGNGTLVIIFFRHRSMRNIPNTYILSLALADLLVILVCVPVATIVYTQESWPFERNM 141
            :.:..||:|||..::....|:..|:...|.||.:|||||.|.... :|..:..|..|:|||...:
Human    57 SAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATST-LPFQSAKYLMETWPFGELL 120

  Fly   142 CRISEFFKDISIGVSVFTLTALSGERYCAIVNPLRKL--QTKPLTVFTAVMIWILAILLGMPSVL 204
            |:........::..|:||||.:|.:||.|:.:|::.|  :|........:.||:||..:|:|.::
Human   121 CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMV 185

  Fly   205 FSDIKSYPVFTATGNMTIEVCSPFRDPEY-----AKFMVAGKALVYYLLPLSIIGALYIMMAKRL 264
            .:       .|...:..:.....|..|.:     .|..|   .|..:::|:.||...|.:|..||
Human   186 MA-------VTRPRDGAVVCMLQFPSPSWYWDTVTKICV---FLFAFVVPILIITVCYGLMLLRL 240

  Fly   265 HMSARNMPGEQQSMQSRTQARARLHVARMVVAFVVVFFICFFPYHVFELWYHFYPTAEEDFDEFW 329
            . |.|.:.|      |:.:.|:...:.|||:..|..|.:|:.|.|:|.:              .|
Human   241 R-SVRLLSG------SKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVI--------------VW 284

  Fly   330 NVLRI----------VGFCTS--FLNSCVNPVALYCVSGVFRQHFNRYLCCICVKRQPHLRQHST 382
            .::.|          :..|.:  :.||.:|||....:...|::.| |.||     |:|
Human   285 TLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCF-RQLC-----RKP------- 336

  Fly   383 ATGMMDNTSVMSMRRST 399
             .|..|.:|....|.:|
Human   337 -CGRPDPSSFSRAREAT 352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCHa2-R	NP_001356958.1	7tmA_Bombesin_R-like	70..362	CDD:320593	80/310 (26%)
		TM helix 1	71..97	CDD:320593	8/25 (32%)
		TM helix 2	104..130	CDD:320593	10/25 (40%)
		TM helix 3	142..172	CDD:320593	10/29 (34%)
		TM helix 4	182..202	CDD:320593	5/19 (26%)
		TM helix 5	234..259	CDD:320593	7/24 (29%)
		TM helix 6	285..315	CDD:320593	10/29 (34%)
		TM helix 7	330..355	CDD:320593	7/36 (19%)
OPRD1	NP_000902.3	7tmA_Delta_opioid_R	50..329	CDD:320217	80/333 (24%)
		TM helix 1	51..77	CDD:320217	8/48 (17%)
		TM helix 2	84..110	CDD:320217	10/26 (38%)
		TM helix 3	121..151	CDD:320217	10/29 (34%)
		TM helix 4	163..185	CDD:320217	6/21 (29%)
		TM helix 5	209..239	CDD:320217	8/32 (25%)
		TM helix 6	258..284	CDD:320217	9/39 (23%)
		TM helix 7	297..322	CDD:320217	6/24 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	340..372		4/13 (31%)