Protein Alignment CCHa2-R and NMBR

DIOPT Version :10

• Sequence 1: NP_001356958.1
• Gene: CCHa2-R / 35535
• FlyBaseID: FBgn0033058
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_002502.2
• Gene: NMBR / 4829
• HGNCID: 7843
• Length: 390
• Species: Homo sapiens
• Alignment Length: 357
• Identity: 129/357 - (36%)
• Similarity: 191/357 - (53%)
• Gaps: 40/357 - (11%)

  Fly    23 GANDSGLLATGQGLEQEQEGLALDMGHNASADGGIVPYVPVLDRPET-----YIVTVLYTLIFIV 82
            |||:||  :..:|.|::                    ::|..|...|     .::..||.||..|
Human    14 GANESG--SVPEGWERD--------------------FLPASDGTTTELVIRCVIPSLYLLIITV 56

  Fly    83 GVLGNGTLVIIFFRHRSMRNIPNTYILSLALADLLVILVCVPVATIVYTQESWPFERNMCRISEF 147
            |:|||..||.||..:.:||::||.:|.:||..|||::|.||||....|..:.|.|.:..|::...
Human    57 GLLGNIMLVKIFITNSAMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWMFGKVGCKLIPV 121

  Fly   148 FKDISIGVSVFTLTALSGERYCAIVNPLRKLQTKPLTVFTAVM---IWILAILLGMPSVLFSDIK 209
            .:..|:|||||||||||.:||.|||||: .:||....:.|.|.   ||::::||.:|..:||::.
Human   122 IQLTSVGVSVFTLTALSADRYRAIVNPM-DMQTSGALLRTCVKAMGIWVVSVLLAVPEAVFSEVA 185

  Fly   210 SYPVFTATGNMTIEVCSPF--RDPEYAKFMVAGKALVYYLLPLSIIGALYIMMAKRLHMSARNMP 272
            .   .::..|.:...|.|:  .|..:.|.......|||:|:||:||...|..:||.|..||.|:|
Human   186 R---ISSLDNSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAHNLP 247

  Fly   273 GEQQSMQSRTQARARLHVARMVVAFVVVFFICFFPYHVFELWYHF-YPTAEEDFDEFWNVLRIVG 336
            ||... .::.|...|..:|::|:.||..|..|:||.|:..::..| |...:......  ::.:|.
Human   248 GEYNE-HTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYRSFNYNEIDPSLGHM--IVTLVA 309

  Fly   337 FCTSFLNSCVNPVALYCVSGVFRQHFNRYLCC 368
            ...||.||||||.|||.:|..||:|||..|||
Human   310 RVLSFGNSCVNPFALYLLSESFRRHFNSQLCC 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCHa2-R	NP_001356958.1	7tmA_Bombesin_R-like	70..362	CDD:320593	113/297 (38%)
		TM helix 1	71..97	CDD:320593	13/25 (52%)
		TM helix 2	104..130	CDD:320593	13/25 (52%)
		TM helix 3	142..172	CDD:320593	16/29 (55%)
		TM helix 4	182..202	CDD:320593	6/22 (27%)
		TM helix 5	234..259	CDD:320593	10/24 (42%)
		TM helix 6	285..315	CDD:320593	10/29 (34%)
		TM helix 7	330..355	CDD:320593	12/24 (50%)
NMBR	NP_002502.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		5/9 (56%)
		7tmA_NMBR	44..335	CDD:320253	113/297 (38%)
		TM helix 1	45..71	CDD:320253	13/25 (52%)
		TM helix 2	78..104	CDD:320253	13/25 (52%)
		TM helix 3	116..146	CDD:320253	16/29 (55%)
		TM helix 4	158..178	CDD:320253	6/19 (32%)
		TM helix 5	209..234	CDD:320253	10/24 (42%)
		TM helix 6	259..289	CDD:320253	10/29 (34%)
		TM helix 7	303..328	CDD:320253	12/26 (46%)