DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCHa2-R and CapaR

DIOPT Version :9

Sequence 1:	NP_001356958.1	Gene:	CCHa2-R / 35535	FlyBaseID:	FBgn0033058	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_996140.1	Gene:	CapaR / 40393	FlyBaseID:	FBgn0037100	Length:	477	Species:	Drosophila melanogaster

Alignment Length:	443	Identity:	125/443 - (28%)
Similarity:	197/443 - (44%)	Gaps:	74/443 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ASLMDVGQTLAARLADSD---GNGANDSGLLATGQGLEQEQEGLALDMGHNASADGGIVPYVPVL 64
            ||..:...||.|....||   |.|..|   .|.|......:|.:|..:|
  Fly    14 ASFTNTPDTLFATSVSSDPSHGFGEED---YACGTFNCSPKEFVAFVLG---------------- 59

  Fly    65 DRPET------YIVTVLYTLIFIVGVLGNGTLVIIFFRHRSMRNIPNTYILSLALADLLVILVCV 123
              |:|      .::|:::..|||.||:||..:.|:..||.:|....|.|:.|||::|||.:|..:
  Fly    60 --PQTLPLYKAVLITIIFGGIFITGVVGNLLVCIVIIRHSAMHTATNYYLFSLAVSDLLYLLFGL 122

  Fly   124 PVATIVYTQESWP--FERNMCRISEFFKDISIGVSVFTLTALSGERYCAIVNPLRKLQ----TKP 182
            |....:|..: :|  |....|:|..|..:....|||||:.|.|.||:.||.:||....    .:.
  Fly   123 PTEVFLYWHQ-YPDLFGMPFCKIRAFISEACTYVSVFTIVAFSMERFLAICHPLHLYAMVGFKRA 186

  Fly   183 LTVFTAVMIWILAILLGMPSVLFSDIK--SYPVFTATGNMTIE---VC--SPFRDPEYAKFMVAG 240
            :.:.||  :||::.:..:|..|.|||:  :||:    .:..||   .|  ||....|...|.|:
  Fly   187 IRIITA--LWIVSFISAIPFGLLSDIQYLNYPL----DHSRIEESAFCSMSPKIVNEIPVFEVS- 244

  Fly   241 KALVYYLLPLSIIGALYIMMAKRLHMSARNMPGEQQSMQSRTQARARLH---VARMVVAFVVVFF 302
             ..:::::|:.:|..||..|..::........|.||...:|....:::.   |.||:.|.|:.||
  Fly   245 -FCIFFVIPMILIILLYGRMGAKIRSRTNQKLGVQQGTNNRETRNSQMRKKTVIRMLAAVVITFF 308

  Fly   303 ICFFPYHVFELWYHFYPTAEEDFDEFWNVLRIVGFCTSFLNSC-VNPVALYCVSGVFRQHFNRYL 366
            :|:||:|:..|.:.:....:...|....:..|.||  ::..|| |||:....:|..:|..|...|
  Fly   309 VCWFPFHLQRLIFLYAKNMDNYLDINEALFSIAGF--AYYVSCTVNPIVYSVMSRRYRVAFRELL 371

  Fly   367 CCICV---KRQPHLRQHSTATGMMDNTSVMSMRRST-YVGGTAGNLRASLHRN 415
            |...|   ......|.||            |.|.|: |....:.::|||.|.|
  Fly   372 CGKAVGAYYNSGFARDHS------------SFRESSAYDRVHSVHVRASQHPN 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCHa2-R	NP_001356958.1	7tmA_Bombesin_R-like	70..362	CDD:320593	92/308 (30%)
		TM helix 1	71..97	CDD:320593	9/25 (36%)
		TM helix 2	104..130	CDD:320593	10/25 (40%)
		TM helix 3	142..172	CDD:320593	13/29 (45%)
		TM helix 4	182..202	CDD:320593	4/19 (21%)
		TM helix 5	234..259	CDD:320593	6/24 (25%)
		TM helix 6	285..315	CDD:320593	12/32 (38%)
		TM helix 7	330..355	CDD:320593	8/25 (32%)
CapaR	NP_996140.1	7tm_4	85..374	CDD:304433	89/299 (30%)
CapaR	NP_996140.1	7tm_1	85..356	CDD:278431	84/281 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438988
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840