DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCHa2-R and GRPR

DIOPT Version :9

Sequence 1:	NP_001356958.1	Gene:	CCHa2-R / 35535	FlyBaseID:	FBgn0033058	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_005305.1	Gene:	GRPR / 2925	HGNCID:	4609	Length:	384	Species:	Homo sapiens

Alignment Length:	377	Identity:	141/377 - (37%)
Similarity:	204/377 - (54%)	Gaps:	41/377 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LALDMGH----NASADGGIVPYVPVLDRPE-TYIVTVLYTLIFIVGVLGNGTLVIIFFRHRSMRN 102
            |.|::.|    |.|:....:|.......|. .|::..:|.:|.::|::||.||:.||...:||||
Human     9 LNLEVDHFMHCNISSHSADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNITLIKIFCTVKSMRN 73

  Fly   103 IPNTYILSLALADLLVILVCVPVATIVYTQESWPFERNMCRISEFFKDISIGVSVFTLTALSGER 167
            :||.:|.||||.|||:::.|.||....|..:.|.|.|..|::..|.:..|:|||||||||||.:|
Human    74 VPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADR 138

  Fly   168 YCAIVNP--------LRKLQTKPLTVFTAVMIWILAILLGMPSVLFSDIKSYPVFTATGNMTIEV 224
            |.|||.|        |.|:..|      |..|||:::||.:|..:|||:  :|....:.|.|...
Human   139 YKAIVRPMDIQASHALMKICLK------AAFIWIISMLLAIPEAVFSDL--HPFHEESTNQTFIS 195

  Fly   225 CSPF--RDPEYAKFMVAGKALVYYLLPLSIIGALYIMMAKRLHMSARNMPGEQQSMQSRTQARAR 287
            |:|:  .:..:.|.......||:|::|||||...|..:||.|..||.|:|.| .::..:.|..:|
Human   196 CAPYPHSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQSAYNLPVE-GNIHVKKQIESR 259

  Fly   288 LHVARMVVAFVVVFFICFFPYHVFELW--YHFYPTAEEDFDEFWNVLRIVGFCTSFLNSCVNPVA 350
            ..:|:.|:.||.:|..|:.|.||..|:  ||:   :|.|......|..|.....:|.||||||.|
Human   260 KRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHY---SEVDTSMLHFVTSICARLLAFTNSCVNPFA 321

  Fly   351 LYCVSGVFRQHFN-RYLCCICVKRQPHL--RQHSTATGMMDNTSVMSMRRST 399
            ||.:|..||:.|| :.|||     ||.|  |.|||..    :|:.|:..:||
Human   322 LYLLSKSFRKQFNTQLLCC-----QPGLIIRSHSTGR----STTCMTSLKST 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCHa2-R	NP_001356958.1	7tmA_Bombesin_R-like	70..362	CDD:320593	118/303 (39%)
		TM helix 1	71..97	CDD:320593	9/25 (36%)
		TM helix 2	104..130	CDD:320593	13/25 (52%)
		TM helix 3	142..172	CDD:320593	17/29 (59%)
		TM helix 4	182..202	CDD:320593	6/19 (32%)
		TM helix 5	234..259	CDD:320593	10/24 (42%)
		TM helix 6	285..315	CDD:320593	11/31 (35%)
		TM helix 7	330..355	CDD:320593	12/24 (50%)
GRPR	NP_005305.1	7tmA_GRPR	41..333	CDD:320252	118/303 (39%)
		TM helix 1	42..68	CDD:320252	9/25 (36%)
		TM helix 2	75..101	CDD:320252	13/25 (52%)
		TM helix 3	113..143	CDD:320252	17/29 (59%)
		TM helix 4	155..175	CDD:320252	8/25 (32%)
		TM helix 5	207..232	CDD:320252	10/24 (42%)
		TM helix 6	257..287	CDD:320252	11/29 (38%)
		TM helix 7	301..326	CDD:320252	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	177	1.000	Domainoid score	I3598
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	217	1.000	Inparanoid score	I3601
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153238at2759
OrthoFinder	1	1.000	-	-		FOG0001846
OrthoInspector	1	1.000	-	-		mtm8658
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45695
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4897
SonicParanoid	1	1.000	-	-		X1046
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	11.060