DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCHa2-R and Tacr2

DIOPT Version :9

Sequence 1:	NP_001356958.1	Gene:	CCHa2-R / 35535	FlyBaseID:	FBgn0033058	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_542946.1	Gene:	Tacr2 / 25007	RGDID:	3812	Length:	390	Species:	Rattus norvegicus

Alignment Length:	414	Identity:	99/414 - (23%)
Similarity:	161/414 - (38%)	Gaps:	92/414 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 YTLIFIVGVLGNGTLVIIFFRHRSMRNIPNTYILSLALADLLVILVCVPVATIVYTQESWPFERN 140
            |..:.:|.|.||.|::.|...|..||.:.|.:|::||||||.:.........|..:...|.|.|.
  Rat    40 YLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGRA 104

  Fly   141 MCRISEFFKDISIGVSVFTLTALSGERYCAIVNPLRKLQTKPLTVFTAVMIWILAILLGMPSVLF 205
            .|.....|...::.||::::||::.:||.|||:|.:...:.|.|......||::|:.|..|...:
  Rat   105 FCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAIIAGIWLVALALASPQCFY 169

  Fly   206 SDIKSYPVFTATGNMTIEVCSPFRDPEYAKFMVA------GKAL---------VYYLLPLSIIGA 255
            |              ||.|     |....|.:||      ||.|         :.|.|||.::..
  Rat   170 S--------------TITV-----DEGATKCVVAWPNDNGGKMLLLYHLVVFVLIYFLPLLVMFG 215

  Fly   256 LYIMMAKRLHMSARNMPGEQQSMQSRTQARARLHVARMVVAFVVVFFICFFPYHVFELWYHFYPT 320
            .|.::.  |.:..|.:|..|....:....:|:....:.:|..|:.|.||:.|||:    |....|
  Rat   216 AYSVIG--LTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVLTFAICWLPYHL----YFILGT 274

  Fly   321 AEED--FDEFWNVLRIVGFCTSFLNSCVNPVALYCVSGVFRQHFN-RYLCCICVKRQPHLRQHST 382
            .:||  :.:|...:.:..|..:..::..||:...|::..||..|. .:.||..|.        .|
  Rat   275 FQEDIYYHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVT--------PT 331

  Fly   383 ATGMMDNTSVMSMRRSTYVGGTAGNLRASLHRNSNHGVGGAGGGVGGGVGSGRVGSFHRQDSM-- 445
            ....::.|...|:.|                                     ||...|.::::
  Rat   332 EEDRLELTHTPSLSR-------------------------------------RVNRCHTKETLFM 359

  Fly   446 --PLQHGNAHGGGAGGGSSGLGAG 467
              .:.|..|..|..|....|..||
  Rat   360 TGDMTHSEATNGQVGSPQDGEPAG 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCHa2-R	NP_001356958.1	7tmA_Bombesin_R-like	70..362	CDD:320593	81/302 (27%)
		TM helix 1	71..97	CDD:320593	7/20 (35%)
		TM helix 2	104..130	CDD:320593	9/25 (36%)
		TM helix 3	142..172	CDD:320593	9/29 (31%)
		TM helix 4	182..202	CDD:320593	6/19 (32%)
		TM helix 5	234..259	CDD:320593	11/39 (28%)
		TM helix 6	285..315	CDD:320593	9/29 (31%)
		TM helix 7	330..355	CDD:320593	4/24 (17%)
Tacr2	NP_542946.1	7tm_4	42..>168	CDD:304433	40/125 (32%)
		7tm_1	50..307	CDD:278431	75/281 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..390		7/19 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4219
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810