DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCHa2-R and Ednra

DIOPT Version :9

Sequence 1:	NP_001356958.1	Gene:	CCHa2-R / 35535	FlyBaseID:	FBgn0033058	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_036682.1	Gene:	Ednra / 24326	RGDID:	2535	Length:	426	Species:	Rattus norvegicus

Alignment Length:	394	Identity:	112/394 - (28%)
Similarity:	185/394 - (46%)	Gaps:	60/394 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 ADGGIVPYVPVLDRPET---YIVTVLYTLIFIVGVLGNGTLVIIFFRHRSMRNIPNTYILSLALA 114
            ::|.:..|.|...:..|   ||.||:...|||||::||.||:.|.::::.|||.||..|.||||.
  Rat    61 SNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALG 125

  Fly   115 DLLVILVCVPVATIVYTQESWPFERN-----MCRISEFFKDISIGVSVFTLTALSGERYCAIVN- 173
            ||:.:::.:|:.........|||:.|     :|::..|.:..|:|::|..|.|||.:||.|:.:
  Rat   126 DLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASW 190

  Fly   174 --------PLRKLQTKPLTVFTAVMIWILAILLGMPSVL------FSDIKSYPVFTATGNMTIEV 224
                    ||       :|....|.||||:.:|.:|..:      | :.|.....|...|.|.:.
  Rat   191 SRVQGIGIPL-------ITAIEIVSIWILSFILAIPEAIGFVMVPF-EYKGEQHRTCMLNATTKF 247

  Fly   225 CSPFRDPEYAKFMVAGKALVYYLLPLSIIGALYIMMAKRLHMSARNMPGEQQSMQSRTQARARLH 289
            ...::|.:  .:.:.|   .|:.:||......|.:|...: ::.||  |..:...|. ..:.|..
  Rat   248 MEFYQDVK--DWWLFG---FYFCMPLVCTAIFYTLMTCEM-LNRRN--GSLRIALSE-HLKQRRE 303

  Fly   290 VARMVVAFVVVFFICFFPYHVFELWYHFYPTAEEDFDE-------FWNVLRIVGFCTSFLNSCVN 347
            ||:.|...||:|.:|:||.|:..:   ...|..::.|:       |..::..:|...:.:|||:|
  Rat   304 VAKTVFCLVVIFALCWFPLHLSRI---LKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCIN 365

  Fly   348 PVALYCVSGVFRQHFNRYLCCICVKRQPHLRQHSTATGMMDNTSVMSMRRSTYVGGTAGNLRASL 412
            |:|||.||..|:..|...|||.|     |..:....:..|:.||:....:.     ...|...|.
  Rat   366 PIALYFVSKKFKNCFQSCLCCCC-----HQSKSLMTSVPMNGTSIQWKNQE-----QNHNTERSS 420

  Fly   413 HRNS 416
            |::|
  Rat   421 HKDS 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCHa2-R	NP_001356958.1	7tmA_Bombesin_R-like	70..362	CDD:320593	95/318 (30%)
		TM helix 1	71..97	CDD:320593	13/25 (52%)
		TM helix 2	104..130	CDD:320593	10/25 (40%)
		TM helix 3	142..172	CDD:320593	12/29 (41%)
		TM helix 4	182..202	CDD:320593	7/19 (37%)
		TM helix 5	234..259	CDD:320593	5/24 (21%)
		TM helix 6	285..315	CDD:320593	11/29 (38%)
		TM helix 7	330..355	CDD:320593	9/24 (38%)
Ednra	NP_036682.1	7tm_1	97..367	CDD:278431	79/289 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910