DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCHa2-R and Tacr3

DIOPT Version :9

Sequence 1:	NP_001356958.1	Gene:	CCHa2-R / 35535	FlyBaseID:	FBgn0033058	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_067357.1	Gene:	Tacr3 / 21338	MGIID:	892968	Length:	452	Species:	Mus musculus

Alignment Length:	368	Identity:	98/368 - (26%)
Similarity:	164/368 - (44%)	Gaps:	44/368 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SDGNG--ANDSGLLATGQGLEQEQEGLALDMGHNASADGGIVPYVPVLDRPETYI---------- 71
            :||..  .:.:|.|:...|:   .|.|||..|:.:||.|     :||..:..:.:
Mouse    11 TDGTAGVGSHTGNLSAALGI---TEWLALQAGNFSSALG-----LPVTSQAPSQVRANLTNQFVQ 67

  Fly    72 -------VTVLYTLIFIVGVLGNGTLVIIFFRHRSMRNIPNTYILSLALADLLVILVCVPVATIV 129
                   .::.|.|:..|.|.||..::.|...|:.||.:.|.::::||.:|..|......|..|.
Mouse    68 PSWRIALWSLAYGLVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASVAAFNTLVNFIY 132

  Fly   130 YTQESWPFERNMCRISEFFKDISIGVSVFTLTALSGERYCAIVNPLRKLQTKPLTVFTAVMIWIL 194
            .....|.|..|.||...||...::..|::::||::.:||.||::||:...:...|......||||
Mouse   133 GVHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWIL 197

  Fly   195 AILLGMPSVLFSDIKSYPVFTATGNMTIEVCSPFRDPEYAKFMVAGKALVYYLLPLSIIGALYIM 259
            |.||..|..|:|.||..|     |.....|..|....::..:.:....|| |..||.|:|..|.:
Mouse   198 AFLLAFPQCLYSKIKVMP-----GRTLCYVQWPEGPKQHFTYHIIVIILV-YCFPLLIMGVTYTI 256

  Fly   260 MAKRLHMSARNMPGEQQSMQSRTQARARLHVARMVVAFVVVFFICFFPYHVFELWYHFYPTAEED 324
            :.  :.:....:||:... :...|.:|:..|.:|::..||.|.||:.||||:.:....|.....
Mouse   257 VG--ITLWGGEIPGDTCD-KYHEQLKAKRKVVKMMIIVVVTFAICWLPYHVYFILTAIYQQLNR- 317

  Fly   325 FDEFWNVLR---IVGFCTSFLNSCVNPVALYCVSGVFRQHFNR 364
                |..::   :..|..:..::..||:...|::..||..|.|
Mouse   318 ----WKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKR 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCHa2-R	NP_001356958.1	7tmA_Bombesin_R-like	70..362	CDD:320593	81/311 (26%)
		TM helix 1	71..97	CDD:320593	7/42 (17%)
		TM helix 2	104..130	CDD:320593	7/25 (28%)
		TM helix 3	142..172	CDD:320593	10/29 (34%)
		TM helix 4	182..202	CDD:320593	8/19 (42%)
		TM helix 5	234..259	CDD:320593	8/24 (33%)
		TM helix 6	285..315	CDD:320593	12/29 (41%)
		TM helix 7	330..355	CDD:320593	4/27 (15%)
Tacr3	NP_067357.1	7tm_4	81..>204	CDD:304433	40/122 (33%)
		7tm_1	89..343	CDD:278431	74/267 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..452
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4219
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900