DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCHa2-R and Ntsr1

DIOPT Version :9

Sequence 1:	NP_001356958.1	Gene:	CCHa2-R / 35535	FlyBaseID:	FBgn0033058	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_061236.1	Gene:	Ntsr1 / 18216	MGIID:	97386	Length:	424	Species:	Mus musculus

Alignment Length:	410	Identity:	103/410 - (25%)
Similarity:	183/410 - (44%)	Gaps:	55/410 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 GLEQEQEGLALDMGHNASADGGIVPYVPVLDRPETY---IVTVLYTLIFIVGVLGNGTLVIIFFR 96
            |||.....|:|..|...|::..:.|...:....:.|   :||.:|..:|:||.:||........|
Mouse    26 GLETMLLALSLSNGSGNSSESILEPNSNLDVNTDIYSKVLVTAVYLALFVVGTVGNSVTAFTLAR 90

  Fly    97 HRSMRNIPNT---YILSLALADLLVILVCVPVA--TIVYTQESWPFERNMCRISEFFKDISIGVS 156
            .:|::::.:|   ::.||||:|||::|:.:||.  ..::....|.|....||...|.:|.....:
Mouse    91 KKSLQSLQSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYAT 155

  Fly   157 VFTLTALSGERYCAIVNPL--RKLQTKPLTVFTAVMIWILAILLGMPSVLFSDIKS------YPV 213
            ...:.:||.|||.||.:|.  :.|.::..|......||:.:.||.:|.:....:::      :|
Mouse   156 ALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGLQNRSADGQHP- 219

  Fly   214 FTATGNMTIEVCSPFRDPEYAKFMVAGKALVYYLLPLSIIGALYIMMAKRL----HMSARN---- 270
                |.:   ||:|..|....|.::.....:.:|.|:.||..|..::|.:|    |.:|..
Mouse   220 ----GGL---VCTPTVDTATVKVVIQVNTFMSFLFPMLIISILNTVIANKLTVMVHQAAEQGRGV 277

  Fly   271 -MPGEQQSMQSRT--------QARARLHVARMVVAFVVVFFICFFPYHVFELWYHF-----YPTA 321
             ..|...|::..|        :.:|..|...::.|.|:.|.:|:.||||..|.:.:     :.|.
Mouse   278 CTVGTHNSLEHSTFNMSIEPGRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTF 342

  Fly   322 EEDFDEFWNVLRIVGFCTSFLNSCVNPVALYCVSGVFRQHFNRYLCCICV------KRQPHLRQH 380
            ..||..::.:|....|   :::|.:||:....||..|||.|...|.|:|.      |::|...:.
Mouse   343 LFDFYHYFYMLTNALF---YVSSAINPILYNLVSANFRQVFLSTLACLCPGWRRRRKKRPTFSRK 404

  Fly   381 STATGMMDNTSVMSMRRSTY 400
            ..:.......|..:.|.:.|
Mouse   405 PNSMSSNHAFSTSATRETLY 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCHa2-R	NP_001356958.1	7tmA_Bombesin_R-like	70..362	CDD:320593	86/329 (26%)
		TM helix 1	71..97	CDD:320593	8/25 (32%)
		TM helix 2	104..130	CDD:320593	11/30 (37%)
		TM helix 3	142..172	CDD:320593	10/29 (34%)
		TM helix 4	182..202	CDD:320593	5/19 (26%)
		TM helix 5	234..259	CDD:320593	6/24 (25%)
		TM helix 6	285..315	CDD:320593	11/29 (38%)
		TM helix 7	330..355	CDD:320593	5/24 (21%)
Ntsr1	NP_061236.1	7tm_1	80..369	CDD:278431	74/299 (25%)
		Neurotensin binding. /evidence=ECO:0000250	326..349		5/22 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..424		3/25 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910