DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCHa2-R and Gpr37l1

DIOPT Version :9

Sequence 1:	NP_001356958.1	Gene:	CCHa2-R / 35535	FlyBaseID:	FBgn0033058	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_602320.2	Gene:	Gpr37l1 / 171469	MGIID:	1928503	Length:	481	Species:	Mus musculus

Alignment Length:	407	Identity:	95/407 - (23%)
Similarity:	180/407 - (44%)	Gaps:	58/407 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 QTLAARLADSDGNGANDSGLLATGQGLEQEQEGLALDMGHNASADGGIV-PYVPVLDRP-ETYIV 72
            :||.|...:.|.:||      ..|.|.|     |.:::....|....|. |..||.:.. ..|.:
Mouse    80 KTLEATSPNPDKDGA------TPGNGQE-----LRVNLTGTPSQRLQIQNPLYPVTESSYSAYAI 133

  Fly    73 TVLYTLIFIVGVLGNGTLVIIFFRHRSMRNIPNTYILSLALADLLVILVCVPVATIVYTQESWPF 137
            .:|..::|.||::||.:::.|.:....:::..|:.:.||||.|.||:..|:|:  :::.:.:  .
Mouse   134 MLLALVVFAVGIVGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFFCLPI--VIFNEIT--K 194

  Fly   138 ERNM----CRISEFFKDISIGVSVFTLTALSGERYCAIVNPLRKLQTKPLTVFTAVM-----IWI 193
            :|.:    ||...|.:..|:||:.|:|.||..:|:....:.|.|:  :|:....:::     ||:
Mouse   195 QRLLGDVSCRAVPFMEVSSLGVTTFSLCALGIDRFHVATSTLPKV--RPIERCQSILAKLAVIWV 257

  Fly   194 LAILLGMPSVLFSDIKSYPVFTATGNMTIEVC--SPFRD-PE--YAKFMVAGKALV------YYL 247
            .:::|.:|.:|...:...|..||.   |::.|  .|..| ||  |:..|....|.:      |:.
Mouse   258 GSMMLAVPELLLWQLAQEPAPTAG---TVDSCIMKPSADLPESVYSLVMTYQNARMWWYFGCYFC 319

  Fly   248 LPLSIIGALYIMMAKRLHMSARNMPGEQQSMQSRTQARARLHVARMVVAFVVVFFICFFPYHVFE 312
            ||:     |:.:..:.:....|..||.:...::....:....:...||...||:..|..|.:|..
Mouse   320 LPI-----LFTVTCQLVTWRVRGPPGRKPECRAGRHEQCESQLNSTVVGLTVVYAFCTLPENVCN 379

  Fly   313 LWYHFYPTAEEDFDEFWNVLRIVGFCTSFLNSCVNPVALYCVSGVFRQHFNRYLCCICVKRQPHL 377
            :...:..|  |...:..::|.::...::|....:.||.|.|:.....|.|....||.|.:.
Mouse   380 IVVAYLST--ELTRQTLDLLGLINQFSTFFKGAITPVLLLCICRPLGQAFLDCCCCCCCEE---- 438

  Fly   378 RQHSTATGMMDNTSVMS 394
                 ..|..|:::.:|
Mouse   439 -----CGGASDSSATVS 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCHa2-R	NP_001356958.1	7tmA_Bombesin_R-like	70..362	CDD:320593	73/311 (23%)
		TM helix 1	71..97	CDD:320593	7/25 (28%)
		TM helix 2	104..130	CDD:320593	10/25 (40%)
		TM helix 3	142..172	CDD:320593	11/29 (38%)
		TM helix 4	182..202	CDD:320593	4/24 (17%)
		TM helix 5	234..259	CDD:320593	6/30 (20%)
		TM helix 6	285..315	CDD:320593	7/29 (24%)
		TM helix 7	330..355	CDD:320593	6/24 (25%)
Gpr37l1	NP_602320.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..55
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..101		8/26 (31%)
		7tm_1	147..397	CDD:278431	61/265 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910