DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCHa2-R and grpr

DIOPT Version :9

Sequence 1:	NP_001356958.1	Gene:	CCHa2-R / 35535	FlyBaseID:	FBgn0033058	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_002938295.1	Gene:	grpr / 100486428	XenbaseID:	XB-GENE-1013137	Length:	384	Species:	Xenopus tropicalis

Alignment Length:	362	Identity:	132/362 - (36%)
Similarity:	198/362 - (54%)	Gaps:	27/362 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LDMGHNASADGGIVPYVPVLDRPETYIVTVLYTLIFIVGVLGNGTLVIIFFRHRSMRNIPNTYIL 109
            |:...|.|:|....|.|       ||.:..:|.:|.::|::||.||:.||...:||||:||.:|.
Frog    22 LNQSSNHSSDDWFYPGV-------TYAIVPVYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFIS 79

  Fly   110 SLALADLLVILVCVPVATIVYTQESWPFERNMCRISEFFKDISIGVSVFTLTALSGERYCAIVNP 174
            ||||.|||:::.|.||....:..:.|.|.|..|::..|.:..|:||||||||||:.:||.|||.|
Frog    80 SLALGDLLLLVTCAPVDASRFLADKWLFGRVGCKLIPFIQLTSVGVSVFTLTALAADRYTAIVRP 144

  Fly   175 LRKLQTKPLT--VFTAVMIWILAILLGMPSVLFSDIKSYPVFTATGNMTIEVCSPFRDPE--YAK 235
            :.......||  ...|.:||||::.|.:|..:|||:  :|.:....|:|...|:|:....  :.:
Frog   145 MDIQANNALTKICIKAALIWILSMTLAIPEAVFSDM--HPFYDKEINVTFVSCAPYPHSNGLHPR 207

  Fly   236 FMVAGKALVYYLLPLSIIGALYIMMAKRLHMSARNMPGEQQSMQSRTQARARLHVARMVVAFVVV 300
            .......|::|::|||||...|..:||.|..||.|||.| .::..|.|..:|..:|:.|:.||.:
Frog   208 IHSTTSFLIFYVIPLSIISVYYYFIAKNLMRSASNMPVE-GNVHVRRQIESRKRLAKTVLVFVGL 271

  Fly   301 FFICFFPYHVFELW--YHFYPTAEEDFDEFWNVLRIVGFCTSFLNSCVNPVALYCVSGVFRQHFN 363
            |..|:.|.|:..|:  ||:   :|.|......:..|.....:|.||||||.|||.:|..||:.||
Frog   272 FAFCWLPIHIIYLYRSYHY---SEVDTSVLHYISSICARVLAFTNSCVNPFALYLLSKSFRKQFN 333

  Fly   364 RYL-CCICVKRQPHLRQHSTATGMMDNTSVMSMRRST 399
            ..| ||     :|.|...:.:.|.  :|:.|:..:||
Frog   334 NQLFCC-----RPRLIVRTQSMGR--STTRMTSLKST 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCHa2-R	NP_001356958.1	7tmA_Bombesin_R-like	70..362	CDD:320593	113/297 (38%)
		TM helix 1	71..97	CDD:320593	9/25 (36%)
		TM helix 2	104..130	CDD:320593	13/25 (52%)
		TM helix 3	142..172	CDD:320593	16/29 (55%)
		TM helix 4	182..202	CDD:320593	8/21 (38%)
		TM helix 5	234..259	CDD:320593	8/24 (33%)
		TM helix 6	285..315	CDD:320593	10/31 (32%)
		TM helix 7	330..355	CDD:320593	11/24 (46%)
grpr	XP_002938295.1	7tmA_GRPR	40..332	CDD:320252	113/297 (38%)
		TM helix 1	41..67	CDD:320252	9/25 (36%)
		TM helix 2	74..100	CDD:320252	13/25 (52%)
		TM helix 3	112..142	CDD:320252	16/29 (55%)
		TM helix 4	154..174	CDD:320252	7/19 (37%)
		TM helix 5	206..231	CDD:320252	8/24 (33%)
		TM helix 6	256..286	CDD:320252	10/29 (34%)
		TM helix 7	300..325	CDD:320252	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	177	1.000	Domainoid score	I3525
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	217	1.000	Inparanoid score	I3495
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153238at2759
OrthoFinder	1	1.000	-	-		FOG0001846
OrthoInspector	1	1.000	-	-		mtm9554
Panther	1	1.100	-	-	LDO	PTHR45695
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4897
SonicParanoid	1	1.000	-	-		X1046
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.100