DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCHa2-R and tacr1a

DIOPT Version :9

Sequence 1:	NP_001356958.1	Gene:	CCHa2-R / 35535	FlyBaseID:	FBgn0033058	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001257407.1	Gene:	tacr1a / 100003539	ZFINID:	ZDB-GENE-060526-185	Length:	426	Species:	Danio rerio

Alignment Length:	332	Identity:	96/332 - (28%)
Similarity:	164/332 - (49%)	Gaps:	26/332 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 NASADGGIVPYVPVLDRPETYIV--TVLYTLIFIVGVLGNGTLVIIFFRHRSMRNIPNTYILSLA 112
            |::|......|.....:|...||  .|.|:.|.:|.|:||.|::.|...|:.||.:.|.::::||
Zfish    17 NSTAQNETEIYWNQFVQPVWRIVLWAVAYSTIVVVSVVGNITVIWIILAHKRMRTVTNYFLVNLA 81

  Fly   113 LADLLVILVCVPVATIVYTQESWPFERNMCRISEFFKDISIGVSVFTLTALSGERYCAIVNPLRK 177
            .|:..:......:..:......|.|....||...||...::..|::::||::.:||.||::||::
Zfish    82 FAEASMSAFNTVINFVYSVHNEWYFGLYYCRFHNFFPIAAVFASIYSMTAIALDRYMAIIHPLQQ 146

  Fly   178 LQTKPLTVFTAVMIWILAILLGMPSVLFSDIKSYPVFTATGNMTIEVCSPFRD-PEY------AK 235
            ..:...|.....:|||||:||..|...:||....|     |.:   ||  :.| |||      ..
Zfish   147 RMSATQTKVVIGVIWILALLLAFPQYYYSDTDQLP-----GRV---VC--YIDWPEYTLLDFKTM 201

  Fly   236 FMVAGKALVYYLLPLSIIGALYIMMAKRLHMSARNMPGEQQSMQSRTQARARLHVARMVVAFVVV 300
            :.|....|:|: |||.::|..|:::.  |.:.|..:||: .|.:.:.|..|:..|.:|::..|..
Zfish   202 YFVCVAVLIYF-LPLLVMGCAYLVVG--LTLWASEIPGD-SSDRYQEQLTAKRKVVKMMIVVVCT 262

  Fly   301 FFICFFPYHVFELWYHFYPTAEEDFDEFWNVLRIVGFCTSFLNSCVNPVALYCVSGVFRQHFNR- 364
            |.:|:.||||:.|.:.|||...|  ..|...:.:.....:..::..||:...|::..||..|.:
Zfish   263 FAVCWLPYHVYFLIHQFYPHLFE--HTFIQQVYLTIMWLAMSSTMYNPIIYCCLNDRFRAGFKQA 325

  Fly   365 YLCCICV 371
            :.||.||
Zfish   326 FRCCPCV 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCHa2-R	NP_001356958.1	7tmA_Bombesin_R-like	70..362	CDD:320593	87/300 (29%)
		TM helix 1	71..97	CDD:320593	11/27 (41%)
		TM helix 2	104..130	CDD:320593	4/25 (16%)
		TM helix 3	142..172	CDD:320593	10/29 (34%)
		TM helix 4	182..202	CDD:320593	8/19 (42%)
		TM helix 5	234..259	CDD:320593	8/24 (33%)
		TM helix 6	285..315	CDD:320593	11/29 (38%)
		TM helix 7	330..355	CDD:320593	3/24 (13%)
tacr1a	NP_001257407.1	7tm_4	47..>221	CDD:304433	55/184 (30%)
tacr1a	NP_001257407.1	7tm_1	55..311	CDD:278431	77/271 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4219
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810