Protein Alignment Tbce and TBCE

DIOPT Version :10

• Sequence 1: NP_610197.2
• Gene: Tbce / 35532
• FlyBaseID: FBgn0033055
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001274730.1
• Gene: TBCE / 6905
• HGNCID: 11582
• Length: 578
• Species: Homo sapiens
• Alignment Length: 582
• Identity: 171/582 - (29%)
• Similarity: 276/582 - (47%)
• Gaps: 86/582 - (14%)

  Fly    14 LGTRIKIGDNYGTVRYVGEVSGHMGSWLGIEWDDGLRGKHNGIVDGKRYFQTQTPTGGSFIRPGK 78
            :|.|:::...:.|||:.|.|....|.|||:|||:..||||:|..:|..||:.:.|||||||||.|
Human    10 IGRRVEVNGEHATVRFAGVVPPVAGPWLGVEWDNPERGKHDGSHEGTVYFKCRHPTGGSFIRPNK 74

  Fly    79 VGPCATLEDAARERYLNYDSSNVDESLIREAQASLQASLFEVVGMDKIARKQSKFEQLEEVSVDQ 143
            |........|.:.||:..|....|.   :|...::.....|.:|.|.|.::||:..:|:|||:..
Human    75 VNFGTDFLTAIKNRYVLEDGPEEDR---KEQIVTIGNKPVETIGFDSIMKQQSQLSKLQEVSLRN 136

  Fly   144 TPVNAA----GYLKELTHLTTLNVSHTLIWNWEIVASIAQQLPSLTNLNLSSNRLVLPTSSQITE 204
            ..|:.|    |..:...::..:::|..|:.:|:.|..||.||..|..||:|.|:|..|:.|.:|
Human   137 CAVSCAGEKGGVAEACPNIRKVDLSKNLLSSWDEVIHIADQLRHLEVLNVSENKLKFPSGSVLT- 200

  Fly   205 LEPSFRQLKRINLRSCGFSDW-----------------KDVM----------------------H 230
              .:...||.:.|...|.: |                 ||..                      |
Human   201 --GTLSVLKVLVLNQTGIT-WAEAHAQCGGSRHGLDMQKDASKFVDLCVLQKCSTSNCIISAKDH 262

  Fly   231 TALLW------------PNILSLGLQENSLGQLAEVDRTKIFKQLHELDLHRTNIMDFDQVTKLG 283
            |::..            |.:..|.|:.|::  ......|.:.:.:..|||....::|.:|:..:.
Human   263 TSMRMNVAKVLRCVAGCPGLEELYLESNNI--FISERPTDVLQTVKLLDLSSNQLIDENQLYLIA 325

  Fly   284 NLTTLRLLNIMENGIEEIKLPDCDSQEKLNIFVSLEQLNLLHNPI--WNEADAFNELDKLPQLKR 346
            :|..|..|.:.:.||..:..||.....|.::|.||:.|.:..|.|  |:   .||||:|||.|:.
Human   326 HLPRLEQLILSDTGISSLHFPDAGIGCKTSMFPSLKYLVVNDNQISQWS---FFNELEKLPSLRA 387

  Fly   347 LS--KTPHLKSNFDEMFSK--AVASIASLQFINKAEVTAEQRRGAEYDIWKKYALDWMQATQGGT 407
            ||  :.|..|.:.:...::  .:|||..|:.:||.|:..|:||.||.|..|.:..:|.||  ||.
Human   388 LSCLRNPLTKEDKEAETARLLIIASIGQLKTLNKCEILPEERRRAELDYRKAFGNEWKQA--GGH 450

  Fly   408 DS------LREFCRRHRTYPLLVKKYGSPADFVPRSQAK---QSNLINVSIR--HQLTGETWEKK 461
            ..      ..||...|..|..|..|||:|.|:..::|..   ::.|:.:.|:  |||..:..||:
Human   451 KDPEKNRLSEEFLTAHPRYQFLCLKYGAPEDWELKTQQPLMLKNQLLTLKIKYPHQLDQKVLEKQ 515

  Fly   462 VPRMITVQTLQGLVMKRFRLSGDVPQLCYVDALHPDLVVPLDNNAKTLDFYSVQEHDTVLVQ 523
            :|..:|:|.::||:.:..::......|.|.....|...:.|:|:.|:|.||||:..|.:||:
Human   516 LPGSMTIQKVKGLLSRLLKVPVSDLLLSYESPKKPGREIELENDLKSLQFYSVENGDCLLVR 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbce	NP_610197.2	CAP_GLY	14..79	CDD:214997	31/64 (48%)
		LRR	<131..376	CDD:443914	75/305 (25%)
		leucine-rich repeat	158..183	CDD:275380	8/24 (33%)
		leucine-rich repeat	184..211	CDD:275380	9/26 (35%)
		leucine-rich repeat	212..238	CDD:275380	10/76 (13%)
		leucine-rich repeat	239..262	CDD:275380	4/22 (18%)
		leucine-rich repeat	263..287	CDD:275380	6/23 (26%)
		leucine-rich repeat	288..317	CDD:275380	8/28 (29%)
		leucine-rich repeat	318..343	CDD:275380	11/26 (42%)
		Ubl_TBCE	443..523	CDD:340564	25/81 (31%)
TBCE	NP_001274730.1	CAP_GLY	10..75	CDD:460154	31/64 (48%)
		LRR	113..>396	CDD:443914	74/291 (25%)
		leucine-rich repeat	129..154	CDD:275380	7/24 (29%)
		leucine-rich repeat	155..180	CDD:275380	8/24 (33%)
		leucine-rich repeat	181..205	CDD:275380	9/26 (35%)
		leucine-rich repeat	206..281	CDD:275380	9/75 (12%)
		Ribosomal_S21e	234..>272	CDD:460133	4/37 (11%)
		leucine-rich repeat	282..304	CDD:275380	4/23 (17%)
		leucine-rich repeat	305..329	CDD:275380	6/23 (26%)
		leucine-rich repeat	330..359	CDD:275380	8/28 (29%)
		leucine-rich repeat	385..415	CDD:275380	8/29 (28%)
		Ubl_TBCE	495..577	CDD:340564	25/81 (31%)