DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbce and coel-1

DIOPT Version :9

Sequence 1:	NP_610197.2	Gene:	Tbce / 35532	FlyBaseID:	FBgn0033055	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_741764.1	Gene:	coel-1 / 180700	WormBaseID:	WBGene00016866	Length:	432	Species:	Caenorhabditis elegans

Alignment Length:	508	Identity:	107/508 - (21%)
Similarity:	189/508 - (37%)	Gaps:	166/508 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 CATLEDAARERYLNYDSSNVDESLI----------REAQASLQASLFEVVGMDKIARKQSKFEQL 136
            |:||..:..::||:.|...|.:.:.          ..:|.:|:..:...:.:|.|...:......
Worm     5 CSTLVRSLEQKYLDDDEDIVQDIIFTGFTGCSPCKMASQRALELLVLNNMNIDTIGDSEKLATLA 69

  Fly   137 EEVSVDQTPVN-------AAGYLKELTHLTTLNVS-----------------HTLIWN-----WE 172
            ..||......|       .|..||.|.||..||:.                 ||:|.|     ::
Worm    70 SHVSEADLGWNQISKWSDIACILKNLPHLRVLNIGHNPLNPVIDHELPVSTLHTIILNGTHLPFK 134

  Fly   173 IVASIAQQLPSLTNLNLSSNRLVLPTSSQITELEPSFRQLKRINLRSCGFSDWKDVMHTALLWPN 237
            .:.|....||.:|.|::|.|:........    ||....::.::|..|||..|..||:....:||
Worm   135 TLQSFLSVLPKVTELHMSDNQFNDDDDCD----EPISTTVRTVHLNRCGFLKWSSVMNVVKRFPN 195

  Fly   238 ILSLGLQENSLGQLAEVDRTKIFKQL---HELDLHRTNIMDFDQVTKLGNLTTLRLLNIMENGIE 299
            :.|:.:.||   .|.:|...|.|:||   :.|:|.:|:|..:|.:.:|..:|:          |.
Worm   196 VCSVFVCEN---PLKDVTHCKHFEQLPFWNFLNLAKTSIDSWDSLDQLNRMTS----------IS 247

  Fly   300 EIKLPDCDSQEKLNIFVSLEQLNLLHNPIWNEADAFNELDKLPQLKRLSKTPHLKSNFDEMFSKA 364
            ::::|        ||            |:         ||.|...:||    ||          .
Worm   248 DLRVP--------NI------------PL---------LDALTNEERL----HL----------I 269

  Fly   365 VASIASLQFINKAEVTAEQRRGAEYDIWKKYALDWMQATQGGTDSLREFCRRHRTYPLLVKKYGS 429
            :..:..|:.:|.:::::|||..:|....:.|               :|...:...|..|:.|:|:
Worm   270 IGRLHHLRVLNGSKISSEQREQSERFFIRYY---------------QEQKEKPLQYKTLIDKHGN 319

  Fly   430 -----PADFVPRSQAKQSNLINVSIRHQLTGETWEKKVPRMITVQTLQGLVMKRFRLSGDVPQLC 489
                 ..|..|:.:|....|..            ||:|.:.||: :|:..|            |.
Worm   320 LEKLVTIDLTPKKEAVVKILCE------------EKEVNQEITI-SLEPTV------------LD 359

  Fly   490 YVDALHPDLVVP--------LDNNAKTLDF-----------YSVQEHDTVLVQ 523
            ::..|.|.:.|.        |..:.:|.||           :.:::.|:.|||
Worm   360 FMKILDPKVGVKFTRMKLFLLREDGRTDDFSSSDYNMPLHYFKIEDGDSFLVQ 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbce	NP_610197.2	CAP_GLY	14..79	CDD:214997
		LRR_RI	<148..268	CDD:330982	40/144 (28%)
		leucine-rich repeat	158..183	CDD:275380	9/46 (20%)
		leucine-rich repeat	184..211	CDD:275380	6/26 (23%)
		leucine-rich repeat	212..238	CDD:275380	8/25 (32%)
		leucine-rich repeat	239..262	CDD:275380	7/22 (32%)
		leucine-rich repeat	263..287	CDD:275380	7/26 (27%)
		leucine-rich repeat	288..317	CDD:275380	4/28 (14%)
		leucine-rich repeat	318..343	CDD:275380	4/24 (17%)
coel-1	NP_741764.1	leucine-rich repeat	46..64	CDD:275378	3/17 (18%)
		leucine-rich repeat	65..97	CDD:275378	7/31 (23%)
		leucine-rich repeat	98..117	CDD:275378	3/18 (17%)
		leucine-rich repeat	121..145	CDD:275378	6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2217
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940