DRSC/TRiP Functional Genomics Resources

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Protein Alignment SCAP and Npc1l1

DIOPT Version :9

Sequence 1:NP_788277.1 Gene:SCAP / 35529 FlyBaseID:FBgn0033052 Length:1276 Species:Drosophila melanogaster
Sequence 2:NP_001002025.1 Gene:Npc1l1 / 432367 RGDID:1303135 Length:1331 Species:Rattus norvegicus


Alignment Length:955 Identity:174/955 - (18%)
Similarity:306/955 - (32%) Gaps:322/955 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 VSHFYYKHGLFLSSYPTCASSIAFMAILLSCYPLINIPLPGTIPTKI-VVPYETGSGSLSWH--- 119
            :..|:...|..::|:|....:::|:.::.....|..|.|. |.|.:: ..|........|:|   
  Rat   337 LGRFFQNWGTRVASWPLTVLALSFIVVIALAAGLTFIELT-TDPVELWSAPKSQARKEKSFHDEH 400

  Fly   120 -------------SLNTSS-------------------------TTPQEPHPSGEPWPPEPQ--- 143
                         :.|.||                         ...||.....:.|.||.:   
  Rat   401 FGPFFRTNQIFVTARNRSSYKYDSLLLGSKNFSGILSLDFLLELLELQERLRHLQVWSPEAERNI 465

  Fly   144 -----------VLNSSTTDRSPPPLLPWAQSSPAFFYV---QQITLRTSVLPWTEGMQLMDAFRA 194
                       ..|:|.:|.....||.:.|::.....:   |.:..:||::.|.:  ..:....|
  Rat   466 SLQDICYAPLNPYNTSLSDCCVNSLLQYFQNNRTLLMLTANQTLNGQTSLVDWKD--HFLYCANA 528

  Fly   195 PLHEVFKLLEIVRNHQSSENKRTLEHNCLHVDNVKRGTHGQLDQIFPEYGCLLLSPANLWTQNSQ 259
            ||  .||            :..:|..:|:       ..:|.  .:||                  
  Rat   529 PL--TFK------------DGTSLALSCM-------ADYGA--PVFP------------------ 552

  Fly   260 NFTRDTNILNTIFQYHNLQKSKVSAAEMLFGL---PMQDTGFKRYPLRARSRIIQYALTLFLKHN 321
                    ...:..|.....|:..|..:.|.|   |..|      |..|::::.:.|   |||. 
  Rat   553 --------FLAVGGYQGTDYSEAEALIITFSLNNYPADD------PRMAQAKLWEEA---FLKE- 599

  Fly   322 DMEYLDTLKEKLLRHYPPLPLASASAEEPTTITYIFYPGEYRMWELVPYTVAFMLVFAYV----- 381
                :::.:......:.....|..|.|:....|.|        .:|..:.|::::||.|:     
  Rat   600 ----MESFQRNTSDKFQVAFSAERSLEDEINRTTI--------QDLPVFAVSYIIVFLYISLALG 652

  Fly   382 -YFSVRKIDVFRSRFLLALCSVITTAGSLAMSLGLCFFFGLTISLQSKDIFPYLVILVGLENSLV 445
             |....::.| .|:..|.|..||...|::..::|...:.|:..||....:.|:||:.||.:|..:
  Rat   653 SYSRCSRVAV-ESKATLGLGGVIVVLGAVLAAMGFYSYLGVPSSLVIIQVVPFLVLAVGADNIFI 716

  Fly   446 ITKSVVSMDETFDVKIRVAQALSKEGWHISKTL-----------LTEITILTIGLATFVPVIQEF 499
            .......:..        .....:|. ||.:||           |:|.....:|..|.:|.::.|
  Rat   717 FVLEYQRLPR--------MPGEQREA-HIGRTLGSVAPSMLLCSLSEAICFFLGALTPMPAVRTF 772

  Fly   500 CIFAIVGLLSDFMLQMLLFSTILAMNIKRTEYTAEAKHLPKMLLSCTQGAGRQDFRFFGAAPALP 564
            .:.:.:.::.||:|||..|..:|:::.||.|                  |.|.|.....:...||
  Rat   773 ALTSGLAIILDFLLQMTAFVALLSLDSKRQE------------------ASRPDVLCCFSTRKLP 819

  Fly   565 P---------------FVPGTFQRSQSHPKLCFADPASVSDRTSL----------VNGHSSPEQR 604
            |               :.|....|        |..|..:....:|          :|.....|..
  Rat   820 PPKEKEGLLLRFFRKIYAPFLLHR--------FIRPVVMLLFLTLFGANLYLMCNINVGLDQELA 876

  Fly   605 IPKRIKIVNFWARTRFFQRAFMIWMIVWICSIVYNSGYLEQLFSMQSNGTMTAT--------LEL 661
            :||...:::::.   |..|...:...|:   .|..||     |:..|...|.||        ..|
  Rat   877 LPKDSYLIDYFL---FLNRYLEVGPPVY---FVTTSG-----FNFSSEAGMNATCSSAGCKSFSL 930

  Fly   662 QRRLQ-------------AGRGAVSSFFEGWQADGQRATSAPSGSGFSTPIKAPLAID------- 706
            .:::|             |....|..|.: |        ..||.|.....|:.|...:       
  Rat   931 TQKIQYASEFPDQSYVAIAASSWVDDFID-W--------LTPSSSCCRLYIRGPHKDEFCPSTDT 986

  Fly   707 ---------------INETAEEMMRLRYPSFDLNYFLSNFHWSTIMKQYNISL-SGHYVTLLPTI 755
                           :..|||:..:.      |.:||::        ..||.. .|.......::
  Rat   987 SFNCLKNCMNRTLGPVRPTAEQFHKY------LPWFLND--------PPNIRCPKGGLAAYRTSV 1037

  Fly   756 RLS---HAIAPELATL---LRNPQEQLQQNFQWKALAAALDPLDFNDDDVRRE------------ 802
            .||   ..||.:....   |||.|:..:.....:.|||.:..      |:|:.            
  Rat  1038 NLSSDGQVIASQFMAYHKPLRNSQDFTEALRASRLLAANITA------DLRKVPGTDPNFEVFPY 1096

  Fly   803 --SPMVMAEGLPLVPKSPMEIFFAILLCCISIFVLCYTMVVFYRC 845
              |.:...:.|.::|    |..|.:.||.:..||:||.::....|
  Rat  1097 TISNVFYQQYLTVLP----EGIFTLALCFVPTFVVCYLLLGLDMC 1137

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SCAPNP_788277.1 Sterol-sensing 390..542 CDD:289145 38/162 (23%)
WD40 <878..1227 CDD:225201
WD40 878..1185 CDD:295369
WD40 repeat 887..942 CDD:293791
WD40 repeat 945..983 CDD:293791
WD40 repeat 989..1070 CDD:293791
WD40 repeat 1079..1114 CDD:293791
WD40 repeat 1120..1157 CDD:293791
WD40 repeat 1162..1196 CDD:293791
WD40 repeat 1201..1233 CDD:293791
Npc1l1NP_001002025.1 NPC1_N 30..283 CDD:293023
2A060601 32..1267 CDD:273337 174/955 (18%)
Sterol-sensing 662..814 CDD:289145 41/179 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1933
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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