DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SCAP and Npc1a

DIOPT Version :9

Sequence 1:NP_788277.1 Gene:SCAP / 35529 FlyBaseID:FBgn0033052 Length:1276 Species:Drosophila melanogaster
Sequence 2:NP_001188769.1 Gene:Npc1a / 34358 FlyBaseID:FBgn0024320 Length:1287 Species:Drosophila melanogaster


Alignment Length:1076 Identity:196/1076 - (18%)
Similarity:373/1076 - (34%) Gaps:334/1076 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 FYYKHGLFLSSYP--TCASSIAFMAILLSCYPLINIPLPGTIPTKIVVPYETGSGSLSWHSLNTS 124
            |:.|.|.:.:|.|  |..:..:.:.||......|.|.   |.|.|:            |.|.|:.
  Fly   341 FFTKWGTYFASNPGLTLIAGASLVVILGYGINFIEIT---TDPVKL------------WASPNSK 390

  Fly   125 STTPQEPHPSGEPWPPEPQVLNSSTTDRSPPPLLPWAQSSPAFFYVQQITLR----------TSV 179
            |...:|                ...|..||            |:.::||.::          ||.
  Fly   391 SRLERE----------------FFDTKFSP------------FYRLEQIIIKAVNLPQIVHNTSN 427

  Fly   180 LPWT-------------------------EGMQLMDAFRAPLHEVFKLLEI-------VRNHQSS 212
            .|:|                         .|.||.|...|||.:....:::       :..:...
  Fly   428 GPYTFGPVFDREFLTKVLDLQEGIKEINANGTQLKDICYAPLSDDGSEIDVSQCVVQSIWGYFGD 492

  Fly   213 ENKRTLEHNCLHVDNVKRGTHGQLDQIFP----EYGCL---------------LLSPANLWTQNS 258
            :.:|..:|:   .||....|:  ||.::.    .|.||               .|.|.:..|.::
  Fly   493 DRERLDDHD---EDNGFNVTY--LDALYDCISNPYLCLAPYGGPVDPAIALGGFLPPGDQLTGST 552

  Fly   259 QNFTRDTNILNTIFQYHNLQKSKVSAAEMLFGLPMQDTGFKRYPLRARSRIIQYALTLFLKHNDM 323
            :....:..||..:.:.|: .|:.:..|                 |....:.::: :|.:.|:|..
  Fly   553 KFELANAIILTFLVKNHH-NKTDLENA-----------------LTWEKKFVEF-MTNYTKNNMS 598

  Fly   324 EYLD-------TLKEKLLRHYPPLPLASASAEEPTTITYIFYPGEYRMWELVPYTVAFMLVFAYV 381
            :|:|       :::::|.|.         |..:..||                 .|:::::|.|:
  Fly   599 QYMDIAFTSERSIEDELNRE---------SQSDVLTI-----------------LVSYLIMFMYI 637

  Fly   382 YFSVRKIDVFR-----SRFLLALCSVITTAGSLAMSLGLCFFFGLTISLQSKDIFPYLVILVGLE 441
            ..|:..:..|:     |:..|.:..||....|:..|:|:..:.||..:|...::.|:||:.||::
  Fly   638 AISLGHVKEFKRVFIDSKITLGIGGVIIVLASVVSSVGVFGYIGLPATLIIVEVIPFLVLAVGVD 702

  Fly   442 NSLVIT----KSVVSMDETFDVKIRVAQALSKEGWHISKTLLTEITILTIGLATFVPVIQEFCIF 502
            |..::.    :.....:||.:.  :|.:.|.|.|..:..|.|:|.....:|..:.:|.::.|.::
  Fly   703 NIFILVQTHQRDQRKPNETLEQ--QVGRILGKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALY 765

  Fly   503 AIVGLLSDFMLQMLLFSTILAMNIKRTEYTAEAKHLPKMLLSCTQGAGRQD---------FRFFG 558
            |.|.|:.||:||:..|.::..::.||.|..       :|.:.|.....:.|         ::||.
  Fly   766 AGVALIIDFLLQITCFVSLFTLDTKRREEN-------RMDICCFIKGKKPDSITSNEGLLYKFFS 823

  Fly   559 AAPALPPFVPGTFQRSQ----SHPKLCFADPASVSDRTSLVNGHSSPEQRIPKRIKIVNFWARTR 619
            :  ...||:.....|:.    ....|||:  .:::.|..:   ....|..:|:...:::::   :
  Fly   824 S--VYVPFLMKKIVRASVMVIFFAWLCFS--IAIAPRIDI---GLDQELAMPQDSFVLHYF---Q 878

  Fly   620 FFQRAFMIWMIVW-----------------ICSIVY--NSGYLEQLF--SMQSNGTMTATLELQR 663
            .......|...|:                 :|:..|  :...|.|::  |..||.|..|      
  Fly   879 SLNENLNIGPPVYFVLKGDLAYTNSSDQNLVCAGQYCNDDSVLTQIYLASRHSNQTYIA------ 937

  Fly   664 RLQAGRGAVSSFFEGWQADGQRATSAPSGSGFSTPIKAPLAIDINETAEEMMRLRYPSF--DLNY 726
              :.....:..:|: |.|...........||...|.:....:..|.|...::|.....|  .|.:
  Fly   938 --RPASSWIDDYFD-WAAAASSCCKYRKDSGDFCPHQDTSCLRCNITKNSLLRPEEKEFVKYLPF 999

  Fly   727 FLSN-----------------FHWSTIMKQYNISLSGHYVTLLPTIRLSHA---IAPELATLLRN 771
            ||.:                 ..:|...::.||..|  |.....||..|.|   :|.|.|   |.
  Fly  1000 FLKDNPDDTCAKAGHAAYGGAVRYSNSHERLNIEAS--YFMAYHTILKSSADYFLALESA---RK 1059

  Fly   772 PQEQLQQNFQWKALAAALDPLDFNDDDVRRESPMVMAEGLPLVPKSPMEIFF------------A 824
            ....:.|..|.:.::..:              ||..|..:.:.|.|...:|:            :
  Fly  1060 ISANITQMLQGRLMSNGV--------------PMASALTVEVFPYSVFYVFYEQYLTMWSDTLQS 1110

  Fly   825 ILLCCISIFVLCYTM----------VVFYRCICTRNYAEWRSSWHESEAPYKQTEQILE-GVPTQ 878
            :.:..:||||:.:.:          ||....:...|.......|:.|.........::. |:..:
  Fly  1111 MGISVLSIFVVTFVLMGFDVHSALVVVITITMIVVNLGGLMYYWNISLNAVSLVNLVMAVGISVE 1175

  Fly   879 IAGHKHRIECLVSDGAYIISCCLKGQIRVWDARSGEQLTSISRSDIQISQQRT---DGQT----- 935
            ...|      ||...|                 :.:.::.|.|:...:|:..:   .|.|     
  Fly  1176 FCSH------LVHSFA-----------------TSKSVSQIDRAADSLSKMGSSIFSGITLTKFA 1217

  Fly   936 --LVRKLAVSPVWCLDYFD---NLIAVGCANGRVEL 966
              ||...|.|.::.:.||.   .::.:|.|:|.:.|
  Fly  1218 GILVLAFAKSQIFQVFYFRMYLGIVVIGAAHGLIFL 1253

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SCAPNP_788277.1 Sterol-sensing 390..542 CDD:289145 40/160 (25%)
WD40 <878..1227 CDD:225201 19/102 (19%)
WD40 878..1185 CDD:295369 19/102 (19%)
WD40 repeat 887..942 CDD:293791 10/64 (16%)
WD40 repeat 945..983 CDD:293791 6/25 (24%)
WD40 repeat 989..1070 CDD:293791
WD40 repeat 1079..1114 CDD:293791
WD40 repeat 1120..1157 CDD:293791
WD40 repeat 1162..1196 CDD:293791
WD40 repeat 1201..1233 CDD:293791
Npc1aNP_001188769.1 NPC1_N 31..274 CDD:293023
2A060601 33..1261 CDD:273337 196/1076 (18%)
Sterol-sensing 651..804 CDD:289145 41/161 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45460570
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1933
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.830

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