DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCAP and NPC1L1

DIOPT Version :9

Sequence 1:	NP_788277.1	Gene:	SCAP / 35529	FlyBaseID:	FBgn0033052	Length:	1276	Species:	Drosophila melanogaster
Sequence 2:	NP_037521.2	Gene:	NPC1L1 / 29881	HGNCID:	7898	Length:	1359	Species:	Homo sapiens

Alignment Length:	1127	Identity:	217/1127 - (19%)
Similarity:	374/1127 - (33%)	Gaps:	351/1127 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PGPA------PSSAGVAG-----------------AAGASSTGLPASVSHFYYKHGLFLSSYPTC 76
            ||.|      |.:.|||.                 ||...:...|.::...:|     |...|
Human   225 PGQAVGSGIQPLNEGVARCNESQGDDVATCSCQDCAASCPAIARPQALDSTFY-----LGQMP-- 282

  Fly    77 ASSIAFMAILLSCYPLINIPL------PGTIPTKIVVPYETGSGSLSWHSLNTSSTTPQEPHPSG 135
             .|:..:.||.|.:.::.|.|      |....:|:|.| :.|:......|.:|.:...|.....|
Human   283 -GSLVLIIILCSVFAVVTILLVGFRVAPARDKSKMVDP-KKGTSLSDKLSFSTHTLLGQFFQGWG 345

  Fly   136 ---EPWPPEPQVLN--------------SSTTDRSPPPLLPW------AQSSPA--------FFY 169
               ..||....||:              ..|||    |:..|      |:|..|        ||.
Human   346 TWVASWPLTILVLSVIPVVALAAGLVFTELTTD----PVELWSAPNSQARSEKAFHDQHFGPFFR 406

  Fly   170 VQQITLRTSVLPWTEGMQLMDAFRAP-----------LHEVFKLLEIVRNHQ--SSENKR--TLE 219
            ..|:.|   ..|.....:.......|           |.|:.:|.|.:|:.|  |.|.:|  :|:
Human   407 TNQVIL---TAPNRSSYRYDSLLLGPKNFSGILDLDLLLELLELQERLRHLQVWSPEAQRNISLQ 468

  Fly   220 HNC---LHVDNVK--RGTHGQLDQIFPEYGCLLLSPAN--LWTQNSQ-----NFTRDTNILNT-- 270
            ..|   |:.||..  ......|.|.|.....|||..||  |..|.||     :|....|...|
Human   469 DICYAPLNPDNTSLYDCCINSLLQYFQNNRTLLLLTANQTLMGQTSQVDWKDHFLYCANAPLTFK 533

  Fly   271 ----------------------IFQYHNLQKSKVSAAEMLFGL---PMQDTGFKRYPLRARSRII 310
                                  |..|.....|:..|..|.|.|   |..|      |..|::::.
Human   534 DGTALALSCMADYGAPVFPFLAIGGYKGKDYSEAEALIMTFSLNNYPAGD------PRLAQAKLW 592

  Fly   311 QYALTLFLKHNDMEYLDTLKEKLLRHYPPLPLASASAEEPTTITYIFYPGEYRMWELVPYTVAFM 375
            :.|.        :|.:...:.::...:....:|..|.|:....|        ...:|..:..:::
Human   593 EEAF--------LEEMRAFQRRMAGMFQVTFMAERSLEDEINRT--------TAEDLPIFATSYI 641

  Fly   376 LVFAYV------YFSVRKIDVFRSRFLLALCSVITTAGSLAMSLGLCFFFGLTISLQSKDIFPYL 434
            ::|.|:      |.|..::.| .|:..|.|..|....|::..::|...:.|:..||....:.|:|
Human   642 VIFLYISLALGSYSSWSRVMV-DSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFL 705

  Fly   435 VILVGLENSLVITKSVVSMDET--FDVKIRVAQALSKEGWHISKTLLTEITILTIGLATFVPVIQ 497
            |:.||.:|..:.......:...  ...::.:.:||.:....:....|:|.....:|..|.:|.::
Human   706 VLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVR 770

  Fly   498 EFCIFAIVGLLSDFMLQMLLFSTILAMNIKRTEYTAEAKHLPKMLLSCTQGAGRQDFRFFGAAPA 562
            .|.:.:.:.::.||:|||..|..:|:::.||.|                  |.|.|.........
Human   771 TFALTSGLAVILDFLLQMSAFVALLSLDSKRQE------------------ASRLDVCCCVKPQE 817

  Fly   563 LPPFVPGTFQRSQSHPKLCFADPASVSDRTSLVNGHSSPEQRIPKRIKIVNFWARTRFFQRAFMI 627
            |||  ||..:                    .|:.|                      |||:|:..
Human   818 LPP--PGQGE--------------------GLLLG----------------------FFQKAYAP 838

  Fly   628 WMIVWI--------------------CSIVYNSGYLEQLFSMQSNGTMTATLELQRRLQAGRGA- 671
            :::.||                    |.|  :.|..::|...:.:..:...|.|.|..:.|...
Human   839 FLLHWITRGVVLLLFLALFGVSLYSMCHI--SVGLDQELALPKDSYLLDYFLFLNRYFEVGAPVY 901

  Fly   672 -VSSFFEGWQAD-GQRATSAPSG-SGFSTPIKAPLAIDINETAEEMMRLRYPSFDLNYFLSNF-H 732
             |::....:.:: |..|..:.:| :.||...|...|.:..|.:       |.:...:.::.:| .
Human   902 FVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATEFPEQS-------YLAIPASSWVDDFID 959

  Fly   733 WSTIMKQYNISLSG--------HYVTLLPTIRLSHAIAPELATL--LRNPQEQLQQNFQW----- 782
            |.|......:.:||        ..|..|..::...:|     |:  :|...||..:...|
Human   960 WLTPSSCCRLYISGPNKDKFCPSTVNSLNCLKNCMSI-----TMGSVRPSVEQFHKYLPWFLNDR 1019

  Fly   783 -------KALAAALDPLDFNDDDVRRESPMVMAEGLPLVPKSPMEIFFAILLCCISIFVLCYT-- 838
                   ..|||....::...|....::..::         ||...:...:....::::|..|
Human  1020 PNIKCPKGGLAAYSTSVNLTSDGQVLDTVAIL---------SPRLEYSGTISAHCNLYLLDSTSR 1075

  Fly   839 MVVFYRCI-CTRNYAEWRSSWHESEA-------------------PYKQTEQILEGVPTQIAGHK 883
            .:.:::.: .:::|.|...:..|..|                   ||..|....|...|
Human  1076 FMAYHKPLKNSQDYTEALRAARELAANITADLRKVPGTDPAFEVFPYTITNVFYEQYLT------ 1134

  Fly   884 HRIECLVSDGAYIISCCLKGQIRV------WDARSG-EQLTSISRSDIQISQQRTDGQTLVRKLA 941
                 ::.:|.:::|.||.....|      .|.||| ..|.||    :.|         ||..:.
Human  1135 -----ILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSI----VMI---------LVDTVG 1181

  Fly   942 VSPVWCLDY----FDNLI-AVG 958
            ...:|.:.|    ..||: |||
Human  1182 FMALWGISYNAVSLINLVSAVG 1203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCAP	NP_788277.1	Sterol-sensing	390..542	CDD:289145	34/153 (22%)
		WD40	<878..1227	CDD:225201	22/93 (24%)
		WD40	878..1185	CDD:295369	22/93 (24%)
		WD40 repeat	887..942	CDD:293791	15/61 (25%)
		WD40 repeat	945..983	CDD:293791	7/19 (37%)
		WD40 repeat	989..1070	CDD:293791
		WD40 repeat	1079..1114	CDD:293791
		WD40 repeat	1120..1157	CDD:293791
		WD40 repeat	1162..1196	CDD:293791
		WD40 repeat	1201..1233	CDD:293791
NPC1L1	NP_037521.2	NPC1_N	31..283	CDD:293023	13/65 (20%)
		2A060601	33..1293	CDD:273337	217/1127 (19%)
		Sterol-sensing	661..814	CDD:289145	37/171 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1933
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900