Protein Alignment SCAP and Npc1

DIOPT Version :9

• Sequence 1: NP_788277.1
• Gene: SCAP / 35529
• FlyBaseID: FBgn0033052
• Length: 1276
• Species: Drosophila melanogaster
• Sequence 2: NP_705888.2
• Gene: Npc1 / 266732
• RGDID: 628693
• Length: 1278
• Species: Rattus norvegicus
• Alignment Length: 621
• Identity: 125/621 - (20%)
• Similarity: 230/621 - (37%)
• Gaps: 187/621 - (30%)

  Fly    39 PSSAGVAGAAGASSTGL-----PASVS------HFYYKHGLFLSSYPTCA--SSIAFMAILLSCY 90
            |..:.:|.::.:|..|.     |..|:      ..:.|.|.|....|||.  .|:.|:|...|..
  Rat   305 PIDSNIAFSSNSSDKGEASCCDPLGVAFDDCLRRMFTKWGAFCVRNPTCIIFFSLVFIAACSSGL 369

  Fly    91 PLINIPLPGTIPTKIVVPYETGSGSLSWHSLNTSSTTPQEPHPSGEPWPPEPQVLNSSTTDRSPP 155
            ..:.:.   |.|.::            |.:          ||....        |.....|:...
  Rat   370 VFVQVT---TNPVEL------------WSA----------PHSQAR--------LEKEYFDKHFG 401

  Fly   156 PLLPWAQSSPAFFYVQQITLR---TSV---LPWTEGMQLMDAFRAP-----LHEVFKLLEIVRNH 209
            |          ||..:|:.::   :||   .|:..|..:  .|..|     ||:|..|...:.:.
  Rat   402 P----------FFRTEQLIIQAPNSSVHIYEPYPSGADV--PFGPPLNKEILHQVLDLQIAIESI 454

  Fly   210 QSSENKRTL-------------EHNC--LHVDNVKRGTHGQLDQ-------IFPEYGCLLL---- 248
            .:|.|..|:             ..||  :.|.|..:.:|..||.       ::.:|....|
  Rat   455 TASYNNETVTLQDICVAPLSPYNKNCTIMSVLNYFQNSHAVLDNQVGDDFFVYADYHTHFLYCVR 519

  Fly   249 SPANLWTQNSQNFTRDTNILNTIFQYHNLQKSKVSAAEMLFGLPM---------QDTGFKRYPLR 304
            :||:|         .||::|:             ......||.|:         .|..:.    .
  Rat   520 APASL---------NDTSLLH-------------GPCLGTFGGPVFPWLVLGGYDDQNYN----N 558

  Fly   305 ARSRIIQYALTLFLKHNDMEYLDTL----KE--KLLRHY--PPLPL---ASASAEEPTTITYIFY 358
            |.:.:|.:.:..:  :||.|.|...    ||  ..:::|  |.|.:   |..|.|:..
  Rat   559 ATALVITFPVNNY--YNDTEKLQRAWAWEKEFINFVKNYKNPNLTISFTAERSIEDEL------- 614

  Fly   359 PGEYRMWELVPYTVAFMLVFAYVYFSVRKIDVFR-----SRFLLALCSVITTAGSLAMSLGLCFF 418
             ......::....:::.::|.|:..::..|..:.     |:..|.:..::....|:..|||:..:
  Rat   615 -NRESNSDVFTVLISYAVMFLYISLALGHIQSWNRVLVDSKISLGIAGILIVLSSVTCSLGIFSY 678

  Fly   419 FGLTISLQSKDIFPYLVILVGLENSLVITKSVVS----MDETFDVKIRVAQALSKEGWHISKTL- 478
            .|:.::|...::.|:||:.||::|..::.::...    .:||.|      |.|.:....::.|:
  Rat   679 IGMPLTLIVIEVIPFLVLAVGVDNIFILVQTYQRDERLQEETLD------QQLGRILGEVAPTMF 737

  Fly   479 ---LTEITILTIGLATFVPVIQEFCIFAIVGLLSDFMLQMLLFSTILAMNIKRTEYTAEAKHLPK 540
               .:|.:....|..:.:|.:..|.:||.:.:|.||:||:..|.:.|.::|||    .|...|.
  Rat   738 LSSFSETSAFFFGALSSMPAVHTFSLFAGMAVLIDFLLQITCFVSFLGLDIKR----QEKNRLD- 797

  Fly   541 MLLSCTQGA--GRQD-------FRFFGAAPALPPFV 567
             :|.|.:|.  |::.       ||||  ..|..||:
  Rat   798 -ILCCVRGPDDGQESQASESYLFRFF--KNAFAPFL 830

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCAP	NP_788277.1	Sterol-sensing	390..542	CDD:289145	38/164 (23%)
		WD40	<878..1227	CDD:225201
		WD40	878..1185	CDD:295369
		WD40 repeat	887..942	CDD:293791
		WD40 repeat	945..983	CDD:293791
		WD40 repeat	989..1070	CDD:293791
		WD40 repeat	1079..1114	CDD:293791
		WD40 repeat	1120..1157	CDD:293791
		WD40 repeat	1162..1196	CDD:293791
		WD40 repeat	1201..1233	CDD:293791
Npc1	NP_705888.2	NPC1_N	24..268	CDD:293023
		2A060601	26..1252	CDD:273337	125/621 (20%)
		Sterol-sensing	650..803	CDD:289145	40/164 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1933
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810