DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SCAP and scp1

DIOPT Version :9

Sequence 1:	NP_788277.1	Gene:	SCAP / 35529	FlyBaseID:	FBgn0033052	Length:	1276	Species:	Drosophila melanogaster
Sequence 2:	NP_596673.1	Gene:	scp1 / 2541065	PomBaseID:	SPBC3B9.15c	Length:	1086	Species:	Schizosaccharomyces pombe

Alignment Length:	322	Identity:	77/322 - (23%)
Similarity:	134/322 - (41%)	Gaps:	68/322 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 QIFPEYG---------CLLLSPANLWTQNSQNFTRDTNILNTIFQYHNLQKSKVSAAEMLFGLP- 292
            |...|||         |:.:||                    |.:|:. :...|:......|||
pombe   115 QYLAEYGYPCIRDEKSCVTISP--------------------IPKYYG-KVDPVAQYSYTKGLPE 158

  Fly   293 --------MQDT---GFKRYPLRARSRIIQYALTLFLKHNDMEYLDTLKEKLLRHYPPLPLASAS 346
                    ..||   ||        ..:..:.:|.|||...::....:.:|.:...|.| .||..
pombe   159 NEREVNKLRNDTIAEGF--------DSLSAFVITYFLKPEQVDTFHVVLKKFISETPNL-YASLL 214

  Fly   347 AEEPTTI-------TYIFYPGEYRMWELVPYTVAFMLVFAYVYFSVRKIDVFRSRFLLALCSVIT 404
            ...|||:       |.|     ||.:..|.:.|.   :|||:|.|:.::...|::|.|.....|.
pombe   215 DTSPTTVVARIPDLTVI-----YRWYLWVGFGVG---LFAYLYLSLVRLHDIRAKFGLTATIFIQ 271

  Fly   405 TAGSLAMSLGLCFFFGLTISLQSKDIFPYLVILVGLENSLVITKSVVSMDETFDVKIRVAQALSK 469
            :..:...:..|.:||..|..:....:..|::|.:.:|||..:.::|::..:|..|..|:.:..|.
pombe   272 SGTAYFSTCSLLYFFERTGPICPWPMAYYIIIFMDIENSFRLLRAVIASPQTKRVPSRIMEGFSS 336

  Fly   470 EGWHISKTLLTEITILTIGLATFV-PVIQEFCIFAIVGLLSDFMLQMLLFSTILAMNIKRTE 530
            .......:||.::..|.: |:.|| |::||||:|.....:..|:|....|..:|:::|:|.|
pombe   337 TIIASFSSLLKKLLTLFV-LSFFVYPLVQEFCLFLACSFVVSFLLHGSFFLAVLSVDIRRLE 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCAP	NP_788277.1	Sterol-sensing	390..542	CDD:289145	37/142 (26%)
		WD40	<878..1227	CDD:225201
		WD40	878..1185	CDD:295369
		WD40 repeat	887..942	CDD:293791
		WD40 repeat	945..983	CDD:293791
		WD40 repeat	989..1070	CDD:293791
		WD40 repeat	1079..1114	CDD:293791
		WD40 repeat	1120..1157	CDD:293791
		WD40 repeat	1162..1196	CDD:293791
		WD40 repeat	1201..1233	CDD:293791
scp1	NP_596673.1	TDT	<178..>305	CDD:296283	33/135 (24%)
		Sterol-sensing	257..410	CDD:289145	37/142 (26%)
		WD40 repeat	598..634	CDD:293791
		WD40 repeat	642..675	CDD:293791
		WD40 repeat	685..717	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	56	1.000	Domainoid score	I3151
eggNOG	1	0.900	-	-		E1_KOG1933
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006370
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46378
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3741
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.030