DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SCAP and Scap

DIOPT Version :9

Sequence 1:NP_788277.1 Gene:SCAP / 35529 FlyBaseID:FBgn0033052 Length:1276 Species:Drosophila melanogaster
Sequence 2:NP_001001144.2 Gene:Scap / 235623 MGIID:2135958 Length:1276 Species:Mus musculus


Alignment Length:1429 Identity:432/1429 - (30%)
Similarity:637/1429 - (44%) Gaps:370/1429 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 LPASVSHFYYKHGLFLSSYPTCASSIAFMAILLSCYPLINIPLPGTIPTKIVVPYETGSGSLSWH 119
            |...:|..:|.|||..:|||........:.||..||||:.:|||||.|.:...|.:         
Mouse     7 LREKISQAFYNHGLLCASYPIPIILFTGLCILACCYPLLKLPLPGTGPVEFSTPVK--------- 62

  Fly   120 SLNTSSTTPQEPHPSGEPWPPEPQVLNSSTTDRSPPPLLPWAQSSPAFFYVQQITLRTSVLPWTE 184
              ..|.......|..||| ..:|:                |...:|. .|:|||.:::||.||..
Mouse    63 --GYSPPPADSDHKQGEP-SEQPE----------------WYVGAPV-AYIQQIFVKSSVSPWHR 107

  Fly   185 GMQLMDAFRAPLHEVFKLLEIVRNH--QSSENKRTLEHNCLHVDNVKRGTHGQLDQIFPEYGCLL 247
            .:..:|.||:||...|:|:|.:|||  :.|...::||..||.|.::..|.. :|..:.||:||||
Mouse   108 NLLAVDVFRSPLSRAFQLVEEIRNHVLRDSSGTKSLEEVCLQVTDLLPGLR-KLRSLLPEHGCLL 171

  Fly   248 LSPANLWTQNSQNFTRDTNILNTIFQYH--NLQKSKVSAAEMLFGLPMQDTGFKRYPLRARSRII 310
            |||.|.|..:.:.|..|.:|:.||.|:.  .||.| .:..::|||:|.:.:|...|   .|.|::
Mouse   172 LSPGNFWQNDWERFHADPDIIGTIHQHEPKTLQTS-ATLKDLLFGVPGKYSGVSLY---TRKRMV 232

  Fly   311 QYALTLFLKHNDMEYLDTLKEKLLRHYPPLPLASASAEEPTTITYIFYPGEYRMWELVPYTVAFM 375
            .|.:||..:....::|.:|:.:|:..:|. |..|..||   .:.::.:..|..:.||:|....::
Mouse   233 SYTITLVFQRYHAKFLSSLRARLMLLHPS-PNCSLRAE---NLVHVHFKEEIGIAELIPLVTTYI 293

  Fly   376 LVFAYVYFSVRKIDVFRSRFLLALCSVITTAGSLAMSLGLCFFFGLTISLQSKDIFPYLVILVGL 440
            ::|||:|||.||||:.:|::.|||.:|:|...||.||:|||..||||.:|...:||||||:::||
Mouse   294 ILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGL 358

  Fly   441 ENSLVITKSVVSMDETFDVKIRVAQALSKEGWHISKTLLTEITILTIGLATFVPVIQEFCIFAIV 505
            ||.||:||||||.....:||:|:||.||.|.|.|.|...||:.|:.||..|.||.|||||:||:|
Mouse   359 ENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNAATELGIILIGYFTLVPAIQEFCLFAVV 423

  Fly   506 GLLSDFMLQMLLFSTILAMNIKRTEYTAEAKHLPKMLLSCTQGA---GRQDFRFFGAAPALPPFV 567
            ||:|||.||||.|:|:|:::|:|.|.....|.||..  ||...|   ||                
Mouse   424 GLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPE--SCLPSAKPVGR---------------- 470

  Fly   568 PGTFQRSQ----SHPKLCFADPASVSDRTSLVNGHSSPEQRIPKRIKIVNFWARTRFFQRAFMIW 628
            |..::|.|    |.|......|:|..:            .|:|||::::.|.||||..||..|..
Mouse   471 PARYERQQAVRPSTPHTITLQPSSFRN------------LRLPKRLRVIYFLARTRLAQRLIMAG 523

  Fly   629 MIVWICSIVYNS-----GYLEQLFSMQSNGTMTATLELQRRLQAGRGAVSSFFEGWQADGQRATS 688
            .:|||..:||..     .||....:.||              ..|.|::...            .
Mouse   524 TVVWIGILVYTDPAGLRTYLAAQVTEQS--------------PLGEGSLGPM------------P 562

  Fly   689 APSG--------SGFST-PIKAPLAIDINET-----------AEEMMRLRYPSF-------DLNY 726
            .|||        ..||. |..|| .:..|:|           ||.:...|.|..       :|..
Mouse   563 VPSGVLPASHPDPAFSIFPPDAP-KLPENQTLPGELPEHAGPAEGVHDSRAPEVTWGPEDEELWR 626

  Fly   727 FLSNFHWSTIMKQYNISLSGHYVTLLPTIRLSHAIAPELATLLRNPQEQLQQNFQWKALAAALDP 791
            .||..||.|:...|||:|:..|::|||.|.::..:.|..|...|:||:       .::..|..:|
Mouse   627 KLSFRHWPTLFNYYNITLAKRYISLLPVIPVTLHLNPREALEGRHPQD-------GRSAWAPQEP 684

  Fly   792 L----------------DFNDDDVRRESPMVMAEGLPLVPKSPMEIFFAILLCCISIFVLCYTMV 840
            |                ...|..:.:.:.:.:|.|:.||          :||.|:          
Mouse   685 LPAGLWESGPKGPGGTQTHGDITLYKVAALGLAAGIVLV----------LLLLCL---------- 729

  Fly   841 VFYRCICTRNYAE---WRSSWHESEAP---YKQTEQILEGVPTQIAGHKHRIECLVSDGAYIISC 899
              ||.:|.|||.:   ........|.|   |.......|.||..:.||...||||.|||..::||
Mouse   730 --YRVLCPRNYGQPGGGPGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIECLASDGMLLVSC 792

  Fly   900 CLKGQIRVWDARSGEQLTSISR----------------------SD------------------- 923
            ||.||:.||||::|:.||.|.|                      ||                   
Mouse   793 CLAGQVCVWDAQTGDCLTRIPRPGPRRDSCGGGAFETQENWERLSDGGKASPEEPGDSPPLRRRP 857

  Fly   924 ------------------------IQISQQRT------------------------------DGQ 934
                                    :|:..:.|                              :|.
Mouse   858 RGPPPPSLFGDQPDLTCLIDTNFSVQLPPEPTQPEPRHRVGCGRSRDSGYDFSRLVQRVYQEEGL 922

  Fly   935 TLVRKLAVSP----------------------------------VWCLDYFDNLIAVGCANGRVE 965
            ..:|..|:.|                                  :|.|:...|||.||.::||:|
Mouse   923 AAMRMPALRPPSPGPPLPQASQEEGTAPEKGSPPLAWTPSTAGSIWSLELQGNLIVVGRSSGRLE 987

  Fly   966 LWESPAGLLKCAYQEDAKRNQGITHIHLNGDRVIVARLNGRLDFYRLETYYKGKQIDWGFTSAYR 1030
            :|::..|:|.|:.:|   .:.|||.:.....|::.|||||.|||:.|||:.....:.      :|
Mouse   988 VWDAIEGVLCCSNEE---ISSGITALVFLDRRIVAARLNGSLDFFSLETHTSLSPLQ------FR 1043

  Fly  1031 RTHVRTGSTGSLGLMLQQQRCQQEASQKTTKEEMKITLEGVRLAHQQPITCMQVVNDMVFTGSQD 1095
            .|..| ||:.|..:.         :|..|.......|   |..|||:|||.::.....:.|||||
Mouse  1044 GTPGR-GSSPSSSVY---------SSSNTVTCHRTHT---VPCAHQKPITALRAAAGRLVTGSQD 1095

  Fly  1096 HTLKVYCLNKSDVEYTLHGHCGPVTCLFVDRWQPGTGGSGSQDGLLCVWDLFTGACMYNIQAHDG 1160
            |||:|:.|:.|...:||.||.|.:|.:::|  |.....||.|||.:|:||:.||:.:....||.|
Mouse  1096 HTLRVFRLDDSCCLFTLKGHSGAITAVYID--QTMVLASGGQDGAICLWDVLTGSRVSQTFAHRG 1158

  Fly  1161 AVSCLACAPSYVISLGTDERICVWERFQGNLLTTINIS-NAYSSLLMLTPSLLVTSKMGSLIVWD 1224
            .|:.|.|..|.|||.|.|:.|.:|:|..|..|.:|... ...:||.:::.:||||...|.:..||
Mouse  1159 DVTSLTCTASCVISSGLDDFISIWDRSTGIKLYSIQQDLGCGASLGVISDNLLVTGGQGCVSFWD 1223

  Fly  1225 VRTG--------------QPAREVKLDFANLQLCPKIMMLACDSVVCDYGNEIRVVRFPIVADK 1274
            :..|              ||||:             |::|...::||::|:|:.:|..|.|.:|
Mouse  1224 LNYGDLLQTVYLGKNSEAQPARQ-------------ILVLDNAAIVCNFGSELSLVYVPSVLEK 1274

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SCAPNP_788277.1 Sterol-sensing 390..542 CDD:289145 81/151 (54%)
WD40 <878..1227 CDD:225201 134/478 (28%)
WD40 878..1185 CDD:295369 120/435 (28%)
WD40 repeat 887..942 CDD:293791 27/149 (18%)
WD40 repeat 945..983 CDD:293791 15/37 (41%)
WD40 repeat 989..1070 CDD:293791 22/80 (28%)
WD40 repeat 1079..1114 CDD:293791 15/34 (44%)
WD40 repeat 1120..1157 CDD:293791 13/36 (36%)
WD40 repeat 1162..1196 CDD:293791 14/33 (42%)
WD40 repeat 1201..1233 CDD:293791 13/45 (29%)
ScapNP_001001144.2 2A060601 <11..>466 CDD:273337 192/494 (39%)
Loop-1. /evidence=ECO:0000250|UniProtKB:P97260 46..284 82/275 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 60..81 6/32 (19%)
Sterol-sensing 308..454 CDD:372063 78/145 (54%)
ER export signal. /evidence=ECO:0000250|UniProtKB:P97260 447..452 1/4 (25%)
Loop-7. /evidence=ECO:0000250|UniProtKB:P97260 535..710 44/208 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 669..698 6/35 (17%)
Interaction with SREBF2. /evidence=ECO:0000250|UniProtKB:P97260 731..1276 160/581 (28%)
WD40 771..802 CDD:197651 16/30 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 834..903 4/68 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 927..960 2/32 (6%)
WD40 repeat 957..998 CDD:293791 13/40 (33%)
WD40 repeat 1008..1071 CDD:293791 22/81 (27%)
WD40 1065..>1232 CDD:392136 65/171 (38%)
WD40 repeat 1079..1113 CDD:293791 14/33 (42%)
WD40 repeat 1120..1154 CDD:293791 13/35 (37%)
WD40 repeat 1160..1194 CDD:293791 14/33 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167833042
Domainoid 1 1.000 176 1.000 Domainoid score I3606
eggNOG 1 0.900 - - E1_KOG1933
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H8160
Inparanoid 1 1.050 594 1.000 Inparanoid score I965
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48668
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0006370
OrthoInspector 1 1.000 - - oto92697
orthoMCL 1 0.900 - - OOG6_107255
Panther 1 1.100 - - LDO PTHR46378
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3741
SonicParanoid 1 1.000 - - X6092
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1514.790

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