DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SCAP and ncr-1

DIOPT Version :9

Sequence 1:	NP_788277.1	Gene:	SCAP / 35529	FlyBaseID:	FBgn0033052	Length:	1276	Species:	Drosophila melanogaster
Sequence 2:	NP_508771.1	Gene:	ncr-1 / 180719	WormBaseID:	WBGene00003561	Length:	1383	Species:	Caenorhabditis elegans

Alignment Length:	464	Identity:	103/464 - (22%)
Similarity:	161/464 - (34%)	Gaps:	149/464 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 EVFKLLEIVRN--HQSSENKR-TLEHNCLHVDNVKRGTHGQLDQIFPEYGCLLLSPANLWTQNSQ 259
            |:|.:|..::|  .|.|:.:. ||:..|..             .:.|.|.||::||.|.:..|.:
Worm   437 ELFDILNAIKNISTQDSDGRTITLDDVCYR-------------PMGPGYDCLIMSPTNYFQGNKE 488

  Fly   260 NFTRDTNILNTI------FQYHN--------------------LQKSK-----------VSAAEM 287
            :....:|...|:      |.|.:                    .||:|           .||..|
Worm   489 HLDMKSNKEETVSEDDDAFDYFSSEATTDEWMNHMAACIDQPMSQKTKSGLSCMGTYGGPSAPNM 553

  Fly   288 LFGLPMQDTGFKRYPLRARSRIIQYALTLFLKHN-----------DMEYLDTLKEKLLRHYPPLP 341
            :||  ...|..     :|.:.|:   :|:.:...           :.|:|...||  .|...|..
Worm   554 VFG--KNSTNH-----QAANSIM---MTILVTQRTEPEIQKAELWEKEFLKFCKE--YREKSPKV 606

  Fly   342 LASASAEEPTTITYIFYPGEYR---MWELVPYTVAFMLVFAYVYFSVRKIDV---------FRSR 394
            :.|..||...|       .|..   ..|:|...:|...:..||.||:.:..|         ..||
Worm   607 IFSFMAERSIT-------DEIENDAKDEIVTVVIALAFLIGYVTFSLGRYFVCENQLWSILVHSR 664

  Fly   395 FLLALCSVITTAGSLAMSLGLCFFFGLTISLQSKDIFPYLVILVGLENSLVITKSVVSM---DET 456
            ..|.:.|||....|...|.|:...||         |.|       ::|:||:...||::   ..|
Worm   665 ICLGMLSVIINLLSSFCSWGIFSMFG---------IHP-------VKNALVVQFFVVTLLGVCRT 713

  Fly   457 F-DVKIRVAQALSKEGWHISKTLLTEITILT--------------------IGLATFVPVIQEFC 500
            | .||....|.:|..  ::|.....||..:.                    ||..|.:|.|:.||
Worm   714 FMVVKYYAQQRVSMP--YMSPDQCPEIVGMVMAGTMPAMFSSSLGCAFSFFIGGFTDLPAIRTFC 776

  Fly   501 IFAIVGLLSDFMLQMLLFSTILAMNIKRTEYTAEAKHLPKMLLSCTQGA---GRQ--------DF 554
            ::|.:.:|.|.:|...:|..:...:.:| |...:.:......:....||   |||        .|
Worm   777 LYAGLAVLIDVVLHCTIFLALFVWDTQR-ELNGKPEFFFPYQIKDLLGAYLIGRQRATDTFMTQF 840

  Fly   555 RFFGAAPAL 563
            ..|..||.|
Worm   841 FHFQVAPFL 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCAP	NP_788277.1	Sterol-sensing	390..542	CDD:289145	42/184 (23%)
		WD40	<878..1227	CDD:225201
		WD40	878..1185	CDD:295369
		WD40 repeat	887..942	CDD:293791
		WD40 repeat	945..983	CDD:293791
		WD40 repeat	989..1070	CDD:293791
		WD40 repeat	1079..1114	CDD:293791
		WD40 repeat	1120..1157	CDD:293791
		WD40 repeat	1162..1196	CDD:293791
		WD40 repeat	1201..1233	CDD:293791
ncr-1	NP_508771.1	2A060601	22..1284	CDD:273337	103/464 (22%)
		NPC1_N	22..251	CDD:293023
		MMPL	660..814	CDD:304422	41/172 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1933
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810