DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SCAP and ncr-2

DIOPT Version :9

Sequence 1:NP_788277.1 Gene:SCAP / 35529 FlyBaseID:FBgn0033052 Length:1276 Species:Drosophila melanogaster
Sequence 2:NP_498813.1 Gene:ncr-2 / 176165 WormBaseID:WBGene00003562 Length:1274 Species:Caenorhabditis elegans


Alignment Length:917 Identity:156/917 - (17%)
Similarity:294/917 - (32%) Gaps:325/917 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 YPLINIPLPGTIPTKIVVPYETGSGSLSWHSLNTSSTTPQEPHPSGEPWPPEPQVLNSSTTDRSP 154
            :|||.:.|      .::|.....||:..:|||..|  ..|.....||....|.:.::|...:.. 
 Worm   331 HPLIFVSL------GLIVAAACCSGNFKFHSLTHS--VDQVSAADGETRRNEKKFIHSFGPNHR- 386

  Fly   155 PPLLPWAQSSPAFFYVQQITLRTSVLPWTEGMQLMDAFRAPL-HEVFKLLEIVRNHQSSENKRTL 218
                           ::||.:  ::.|.|:.|     |..|| .|:|:|:..::|..:       
 Worm   387 ---------------IEQIFI--NLPPTTKSM-----FNMPLFEEMFQLVGNIQNLTA------- 422

  Fly   219 EHNCLHVDNVKRGTHGQLDQIF-----PEYGCLLLSPANLWTQNSQNF------TRDTNILN--- 269
               |....:||      ||.|.     ..:||.::||.|.:.....||      |.|..|.:   
 Worm   423 ---CYGNSSVK------LDDICYKPIGKNHGCAIMSPTNYFQNKWTNFENAGPPTIDDEIFDDQH 478

  Fly   270 ------------TIFQYHNL------------------QKSKVSAAEMLFGLPMQDTGFKRYPLR 304
                        |:..|..:                  ....:..|||.:              .
 Worm   479 WEHLKYCIRNPLTVSTYSEMSCFGEFSGPIDPILVFGGSNESIKGAEMYY--------------T 529

  Fly   305 ARSRIIQYAL-----------TLFL--------KHNDMEYL--DTLKEKLLRHYPPLPLASASAE 348
            ||:.:|...:           |.||        ||.:..::  .::.|::  |         :|.
 Worm   530 ARTIMITVLIRGPEDQAIAWETAFLNMMSRYEMKHANFTFMTETSVAEEI--H---------TAV 583

  Fly   349 EPTTITYIFYPGEYRMWEL----VPYTVAFMLVFAYVYFSVRKIDVFRSRFLLALCSVITTAGSL 409
            |...|..:.......:|.:    :.:.....::.|.|:          .:.|:::.:|:.:..|:
 Worm   584 ETDKIVSVIACAAVLIWVITMLGINHWPESSILSALVH----------HKLLISISAVMISVISV 638

  Fly   410 AMSLGLCFFFGLTISLQSKDIFPYLVILVGLENSLVITKSVVSMDETF--------DVKIRVAQA 466
            ..|:|:...||:..:..:..:..:::..:|:....||.::..:....:        ::..|::..
 Worm   639 WCSIGMFSLFGVHATDNAIVVLFFVITCLGINRIFVIIRTFQANGHCYGLPNISYREMNHRISNV 703

  Fly   467 LSKE-GWHISKTLLTEITILTIG-----LATFVPVIQEFCIFAIVGLLSDFMLQMLLFSTILAMN 525
            :.:. ...::.:|:....:...|     ::..:|.::.|...|.:.:|.|....:|:...:...:
 Worm   704 MRRSIPIVLTNSLICSTCLFLAGGVLPYVSVSMPAVEVFARHAGLAILMDTAFYLLVMLPLFQYD 768

  Fly   526 IKRTEYTAEAKHLPKMLLSCTQGAGRQDFRFFGAAPALPPFVPGTFQRSQSHPKLCFADPASVSD 590
            .:| |.:.:.:..|...||                             ::|...||.        
 Worm   769 ARR-EMSGKCEIWPWYELS-----------------------------NESKINLCM-------- 795

  Fly   591 RTSLVNGH-SSPEQRIPKRI------KIVNFWARTRFFQRAFMIWMIVWICSIVYNSGYLEQLFS 648
              ..|:|: .||.......|      ||...|..|.|    |:..:|...|::....|: .|:.:
 Worm   796 --EAVDGNLRSPVDWFKLAIAPLLLKKICRIWIATFF----FVSLIIACYCTLCLEFGF-NQVMA 853

  Fly   649 MQSNGTMTATLE-LQRRLQAG-------RGAVSSFFEGWQADGQRATSAPSGSGFSTPIKAPLA- 704
            ......:|...: :...|..|       .|.|.     |.....:       :.|.|     || 
 Worm   854 FSETSYLTKHFQNMNENLNIGPPLWFVVEGDVK-----WHDPKMQ-------NKFCT-----LAG 901

  Fly   705 IDINETAEEMMRLRYPS--------FDLNYFLSNF-------------------------HWSTI 736
            .|.|....::..|.|..        .|:|.:|.::                         |.|:.
 Worm   902 CDDNSMGNKIRSLAYAENYKGNYLHGDVNIWLDSYLQFMHPRGSCCKMDGKQFCDPSNATHCSSC 966

  Fly   737 MKQYNISLS----------GHYVTLLPTIRLSH---AIAPELATLLRNPQEQ------------L 776
            ......||:          .|::...|:|:.:|   |:|.....|.||.:.|            |
 Worm   967 SSSSVASLTTTEYEFYRNLHHFLETPPSIQCAHGGMALAKPAINLTRNGKIQSAYFSTFFKKLNL 1031

  Fly   777 QQNFQ----W---KALAAALDPLDFNDDDVRRESPMVMAEGLPLVPKSPMEIFFAILLCCISIFV 834
            ..:.|    |   |.||          ||:.||..      :|.|.......||......:::..
 Worm  1032 SDSIQLYDAWRFAKYLA----------DDIERELE------IPGVKVYVYSTFFPYYEQYLTLST 1080

  Fly   835 LCYTMVV 841
            ..||:||
 Worm  1081 TVYTLVV 1087

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SCAPNP_788277.1 Sterol-sensing 390..542 CDD:289145 22/165 (13%)
WD40 <878..1227 CDD:225201
WD40 878..1185 CDD:295369
WD40 repeat 887..942 CDD:293791
WD40 repeat 945..983 CDD:293791
WD40 repeat 989..1070 CDD:293791
WD40 repeat 1079..1114 CDD:293791
WD40 repeat 1120..1157 CDD:293791
WD40 repeat 1162..1196 CDD:293791
WD40 repeat 1201..1233 CDD:293791
ncr-2NP_498813.1 NPC1_N 29..242 CDD:293023
2A060601 85..1236 CDD:273337 156/917 (17%)
MMPL 619..783 CDD:304422 23/174 (13%)
MMPL <1107..1236 CDD:304422
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1933
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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