DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCAP and scp-1

DIOPT Version :9

Sequence 1:	NP_788277.1	Gene:	SCAP / 35529	FlyBaseID:	FBgn0033052	Length:	1276	Species:	Drosophila melanogaster
Sequence 2:	NP_001022051.1	Gene:	scp-1 / 174479	WormBaseID:	WBGene00004744	Length:	1087	Species:	Caenorhabditis elegans

Alignment Length:	1295	Identity:	291/1295 - (22%)
Similarity:	529/1295 - (40%)	Gaps:	302/1295 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 VSHFYYKHGLFLSSYPTCASSIAFMAILLSCYPLINIPLPGTIPTKIVVPYETGSGSLSWHSLNT 123
            :.:.|:.:|...:::|....|::.:.:::..||.|         |::.:|..|
Worm    16 IGNAYHDYGRLCAAHPKACLSMSLLTMIVLSYPTI---------TRLRLPVST------------ 59

  Fly   124 SSTTPQEPHPSGEPWPPEPQVLNSSTTDRSPPPLLPWAQSSPAFFYVQQITLRTSVLPW--TEGM 186
                     |....|.....|     .|:..|   .|...:|| .|:||..:.|::.||  || |
Worm    60 ---------PIDVFWSEHLHV-----NDKIAP---FWINENPA-SYIQQFIVSTTISPWNATE-M 105

  Fly   187 QLMDAFRAPLHEVFKLLEIVRNHQSSENKRTLEHNCLHVDNVKRGTHGQLDQIFP---EYGCLLL 248
            ....|.||.:...|::.:|:....:      :|..||.:.|.::      |..:|   :..|::|
Worm   106 GPEHAVRAAIATAFRIRQILLAEPA------VEELCLRLANQRQ------DSSWPFRSKSLCVVL 158

  Fly   249 SPANLWTQNSQNFTRDTNILNTIFQYHNLQKSKVSAAEMLFGLPMQDTGFKRYPLRARSRIIQYA 313
            |||::|..|.|.|..|.:.:.|:|..|  .||.....::|.|.|:..||.|:.....|.|.|::|
Worm   159 SPASIWYNNLQKFREDDDTITTVFNEH--CKSTFCMRDLLLGAPIAATGIKQKYQTNRKRKIEFA 221

  Fly   314 LTLFLKHNDMEYLDTLKEKLLRHY-----PPLPLASASAEEPTTITYIFYP----GEYRMWELVP 369
            :|:|......:.:..::|||.:.:     ||       .::.|.:...|:|    .:|     :|
Worm   222 VTMFFARYSKKVIQGIREKLQKEFELVDTPP-------NDQRTFVQVYFHPLKTFSDY-----IP 274

  Fly   370 YTVAFMLVFAYVYFSVRKIDVFRSRFLLALCSVITTAGSLAMSLGLCFFFGLTISLQSKDIFPYL 434
            ....:.:...|||:|.|||.:..||:.||..|..|.|.:|.|:.|:|....|:.:....:::||:
Worm   275 LISTYFVCMIYVYYSSRKIQMVASRWGLAFASSFTVASTLLMTTGICAHLDLSTTTWGSEVYPYI 339

  Fly   435 VILVGLENSLVITKSVVSMDETFDVKIRVAQALSKEGWHISKTLLTEITILTIGLATFVPVIQEF 499
            .:::||||:|.||:|||....:.||..|:|..||:||:.::|..:.|:..|.||..|.:..||||
Worm   340 ALIMGLENTLCITRSVVYTSPSLDVSSRIAHGLSQEGYKLTKYYILELLALLIGFLTRISDIQEF 404

  Fly   500 CIFAIVGLLSDFMLQMLLFSTILAMNIKRTEYTAEAKHLPKMLLSCTQGAGRQDFRFFGAAPALP 564
            |.|:::.:..||.:|:..::..|..:::|.. ..|.:...::||             :...|.|.
Worm   405 CQFSVICVTVDFYMQLFFYAPCLTFDLQRLG-LEEKRKFAEILL-------------YEEIPRLK 455

  Fly   565 PFVPGTFQRSQSHPKLCF---ADPASVSD------------RTSLVNG-----------HSSPEQ 603
            .:.|.:....:..|||..   .....|||            |..|::.           ...||.
Worm   456 NYAPVSCPMRKIWPKLFVMKKMQKRRVSDSGIEDVMKNDEQRRLLISSEFDSKDDGDVQEPRPED 520

  Fly   604 RIPKRIKIVNFWARTRFFQRAFMIWMIVWICSIVYNSGYLEQLFSMQSNGTMTATLELQR----- 663
            .:  |:||:.|..|||..||..::...:|...:|:..|  .:...|:||.|..:...|.|
Worm   521 SV--RMKIMYFITRTRIVQRTILVVFAIWTVFLVFFVG--SRQLGMESNLTNQSIESLTRSHRIL 581

  Fly   664 ---RLQAGRGAVSSFFEGWQADGQRATSAPSGSGFSTPIKAPLAIDINETAEEMMRLRYPSFDLN 725
               .||.|         .||                                   |..|.
Worm   582 STANLQYG---------NWQ-----------------------------------RRTYK----- 597

  Fly   726 YFLSNFHWSTIMKQYNISLSGHYVTLLPTIRLSHAIAPELATLLRNPQEQLQQNFQWKALAAALD 790
                  .|..:..:|||||:..|||.||.|.::..:         :|.:.|.||         ::
Worm   598 ------WWPPVAHEYNISLNSRYVTFLPPIVINAIV---------HPTDILLQN---------VE 638

  Fly   791 PLDFNDDDVRRESPMVMA--EGLPLVPKSPMEIFFAILLCCISIFVLCYTMVVFYRCICTRNYAE 853
            ....|..:...::|::.:  :.|.:..|..:..|:.:|:..:..|.....::..::....:...|
Worm   639 KTHVNVPNEEEDAPILRSRIDWLEMQLKMYLAAFWLLLITTVISFFAYVFLIDRWKLRGVKQIQE 703

  Fly   854 WRSSWHESEAPYKQT-EQILEGVPTQIAGHKHRIECLV---SDGAYIISCCLKGQIRVWDARSGE 914
            .:.|  |:.....:| :..::.:|....||:..||.:.   .|.:..:|||.:|.:.||:.::|:
Worm   704 QQMS--ETTTDSSETVKNFVDTLPIVYQGHRFPIESVAIDPEDTSTFVSCCQEGVVYVWNTQTGQ 766

  Fly   915 QLTSISRSDIQISQQRTDGQTLVRKLAVSP-VWCLDYFDNLIAVGCANGRVELWESPAGLLKCAY 978
            :...|:|  ::...::.      :::..:| :|.:...::::.:||.:|.:|:.......|...|
Worm   767 RTLRINR--LRAVPEKG------KEIPSAPKIWAIAKRNDIVILGCCDGSIEIASISRNKLIGLY 823

  Fly   979 QEDAKRNQGITHIHLNGDRVIVARLNGRLDFYRLETYYKGKQIDWGFTSAYRRTHVRTGSTGSLG 1043
               .|...|.:|:....|.|.|.||:|.::|.|::               |.||
Worm   824 ---TKSTIGASHVVCREDDVAVVRLDGSIEFLRID---------------YDRT----------- 859

  Fly  1044 LMLQQQRCQQEASQKTTKEEMKITLEGVRLAHQQPITCMQVVNDMVFTGSQDHTLKVYCLNKS-- 1106
                      :.:.:..|.|:   |:.|| |||:|:..:.:....:.|.|.|.::|::...::
Worm   860 ----------DGTIRVRKIEL---LKSVR-AHQKPVCRIAIWKSQLITSSFDRSIKMWNWAENPE 910

  Fly  1107 --DVEYTLHGHCGPVTCLFVDRWQPGTGGSGSQDGLLCVWDLFTGACMYNIQAHDGAVSC---LA 1166
              |:......|..||..|.||. ......|..::|::|.|:|.||..   |:.:|...:.   ||
Worm   911 QIDISNVFLAHNSPVVNLAVDE-ATSIMYSSCEEGVICWWNLNTGEL---IRTNDNNYTWAFQLA 971

  Fly  1167 CAPSYVISLGTDERICVWERFQGNLLTTINISNAY--------------SSLLMLTPSLLVTSKM 1217
            .:..|::......::.:|....|.|  ...:|:|.              |.::.....:..|:..
Worm   972 TSSDYLLGFYGSSQLYMWNVENGQL--ACRVSDALGDGTSEDTLYTVGSSGVVSFDDQVAATTSS 1034

  Fly  1218 GSLIVWDVRTGQPAREVKLDFANLQLCPKIMML---ACDSVVCDYGNEIRVVRFPIVADK 1274
            .|:..||::......:|||:       .||..:   ...||:|...|.:..|..|:|..|
Worm  1035 DSVTFWDLKHRAIIGKVKLN-------GKISSMRKNTSHSVLCGVDNSMYSVTVPLVRFK 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCAP	NP_788277.1	Sterol-sensing	390..542	CDD:289145	50/151 (33%)
		WD40	<878..1227	CDD:225201	78/373 (21%)
		WD40	878..1185	CDD:295369	68/317 (21%)
		WD40 repeat	887..942	CDD:293791	11/57 (19%)
		WD40 repeat	945..983	CDD:293791	7/37 (19%)
		WD40 repeat	989..1070	CDD:293791	15/80 (19%)
		WD40 repeat	1079..1114	CDD:293791	5/38 (13%)
		WD40 repeat	1120..1157	CDD:293791	11/36 (31%)
		WD40 repeat	1162..1196	CDD:293791	6/36 (17%)
		WD40 repeat	1201..1233	CDD:293791	5/45 (11%)
scp-1	NP_001022051.1	Sterol-sensing	295..448	CDD:289145	52/166 (31%)
		WD40	<727..1043	CDD:225201	78/372 (21%)
		WD40	727..959	CDD:295369	64/286 (22%)
		WD40 repeat	735..770	CDD:293791	10/34 (29%)
		WD40 repeat	791..826	CDD:293791	7/37 (19%)
		WD40 repeat	833..875	CDD:293791	14/80 (18%)
		WD40 repeat	883..919	CDD:293791	5/35 (14%)
		WD40 repeat	926..949	CDD:293791	6/23 (26%)
		WD40 repeat	967..1005	CDD:293791	8/39 (21%)
		WD40 repeat	1016..1040	CDD:293791	3/23 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	104	1.000	Domainoid score	I4218
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8160
Inparanoid	1	1.050	260	1.000	Inparanoid score	I1917
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48668
OrthoDB	1	1.010	-	-		D242783at33208
OrthoFinder	1	1.000	-	-		FOG0006370
OrthoInspector	1	1.000	-	-		oto18050
orthoMCL	1	0.900	-	-		OOG6_107255
Panther	1	1.100	-	-	LDO	PTHR46378
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3741
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.010