Protein Alignment SCAP and SCAP

DIOPT Version :10

• Sequence 1: NP_788277.1
• Gene: SCAP / 35529
• FlyBaseID: FBgn0033052
• Length: 1276
• Species: Drosophila melanogaster
• Sequence 2: XP_061509303.1
• Gene: SCAP / 1270602
• VectorBaseID: AGAMI1_002462
• Length: 1513
• Species: Anopheles gambiae
• Alignment Length: 1496
• Identity: 705/1496 - (47%)
• Similarity: 899/1496 - (60%)
• Gaps: 290/1496 - (19%)

  Fly    14 AASSTSPRTAASNSSGLAGKPPGPAPSSAGVAGAAGASSTGLPASVSHFYYKHGLFLSSYPTCAS 78
            |.....||..|: ::|..|.|..|:..|.|..|:.|  .|.||:.||..|||||||||||||.|:
Mosquito    73 ATMKPPPRPTAT-TAGARGPPKSPSDRSKGAGGSTG--GTTLPSRVSQIYYKHGLFLSSYPTTAT 134

  Fly    79 SIAFMAILLSCYPLINIPLPGTIPTKIVVPYETGSGSLSWHSLNTSSTTPQEPHP---SGEPWPP 140
            |.|...|:..||||:|||||||||||::.|| |.|.|.:.| |:.::.|.:..:|   ||
Mosquito   135 SFALAIIIFCCYPLLNIPLPGTIPTKVIFPY-TESISENLH-LSNANLTSEFYNPFSFSG----- 192

  Fly   141 EPQVLNSSTTDRSPPPLLPWAQSSPAFFYVQQITLRTSVLPWTEGMQLMDAFRAPLHEVFKLLEI 205
             ..:.|........|  .|||:..| ..|||||.:||||:||.:.:.|.|||||||:||||||||
Mosquito   193 -GNMFNIYNISVETP--FPWARIDP-LLYVQQIIMRTSVVPWEDDLLLTDAFRAPLYEVFKLLEI 253

  Fly   206 VRNHQSSENKRTLEHNCLHVDNVKRGTHGQLDQIFPEYGCLLLSPANLWTQNSQNFTRDTNILNT 270
            :|||: .::|..|.|.||||:||||.:.   ..:||||.||||||||||.||.|||.:|:|:|||
Mosquito   254 IRNHE-DQSKTMLSHLCLHVENVKRSSQ---QTLFPEYNCLLLSPANLWQQNMQNFNKDSNLLNT 314

  Fly   271 IFQYHNLQKSKVSAAEMLFGLPMQDTGFKRYPLRARSRIIQYALTLFLKHNDMEYLDTLKEKLLR 335
            ::..|||||||||.||||||:|::|||.||||:|.|.||||||:||.|:.|:..::::||:||.|
Mosquito   315 VYVNHNLQKSKVSTAEMLFGIPLRDTGVKRYPMRVRPRIIQYAVTLILRENNPAFIESLKQKLTR 379

  Fly   336 HY---------------PPLPLASASAEEPTTITYIFYPGEYRMWELVPYTVAFMLVFAYVYFSV 385
            .|               |..|.|.::.::..:|.|||||||:...|::|..:||.::|.||||||
Mosquito   380 AYPLHQKEPSTDASGGVPAQPEAPSAPKQQQSIMYIFYPGEFNWKEVLPQCIAFCVLFIYVYFSV 444

  Fly   386 RKIDVFRSRFLLALCSVITTAGSLAMSLGLCFFFGLTISLQSKDIFPYLVILVGLENSLVITKSV 450
            |||:..|||.:||.|:|:|..|||.||||||||||||||.|||.::|||||||||||.|||||||
Mosquito   445 RKIEAIRSRIMLASCAVLTVLGSLLMSLGLCFFFGLTISFQSKGVYPYLVILVGLENVLVITKSV 509

  Fly   451 VSMDETFDVKIRVAQALSKEGWHISKTLLTEITILTIGLATFVPVIQEFCIFAIVGLLSDFMLQM 515
            ::.|...||||||||.||:|||.|:|.|||||||||.||||||||||||||||:|||:|||:|||
Mosquito   510 LTTDNNLDVKIRVAQGLSREGWSITKNLLTEITILTGGLATFVPVIQEFCIFAMVGLVSDFLLQM 574

  Fly   516 LLFSTILAMNIKRTEYTAEAKHLPKMLL---SCTQGAG---------RQDFRFFGAAPALPPFVP 568
            |.|:|:||::|||.||:||.:.|||||.   ...:|.|         .::.|..|
Mosquito   575 LFFATVLALDIKRVEYSAEVRRLPKMLYFNNELRRGTGAAAGQANGPAREVRNGG---------- 629

  Fly   569 GTFQRSQSHPKLCFADPASVSDRTSLVNGHSSPEQRIPKRIKIVNFWARTRFFQRAFMIWMIVWI 633
            |:..||:|||||...:.|:...:|...:|   .:.:||||::|||||||||||||.|||||::||
Mosquito   630 GSINRSRSHPKLTGLEQAASHPKTGPGSG---KDVKIPKRLRIVNFWARTRFFQRGFMIWMVLWI 691

  Fly   634 CSIVYNSGYLEQLFSMQSNGT----------------------------MTATLELQR------- 663
            .:|:||:|.:|:||.:..|.|                            ..||||:.|
Mosquito   692 SNIIYNAGLIEELFVIDKNLTGHERLPLDAGAPRFEGGGLAMHDLGDPSTEATLEMDRLNYHKNL 756

  Fly   664 ----RLQAGRGAVSSFFEGWQADGQRATSAPSGSGFSTPIKAPLAIDINETAEEMMRLRYPSFDL 724
                .|:.|.|..|          .:|.:|..           .|:::   :|::.||::|.::.
Mosquito   757 PDAGMLRGGGGVAS----------DKAGTAEH-----------RALNV---SEQLQRLKHPDYET 797

  Fly   725 NYFLSNFHWSTIMKQYNISLSGHYVTLLPTIRLSHAIAPELATLLRNPQEQLQQNFQWKALAAAL 789
            .|.|||||||:|:||||:||||.|||:||.|:||||::|..|..|||..|:...:|||||||.||
Mosquito   798 VYQLSNFHWSSILKQYNVSLSGRYVTVLPAIKLSHAVSPATAIQLRNADEKAPHHFQWKALAVAL 862

  Fly   790 DPLDFNDDDVRRESPMVMAEGLPLVPKSPMEIFFAILLCCISIFVLCYTMVVFYRCICTRNYAEW 854
            |||||:|.|....|.:.:... |..||:||||....:|..:|.||:.|||:|.|||:||||||||
Mosquito   863 DPLDFSDADTGDGSHVPIGNA-PFYPKTPMEILLTCMLLVVSTFVVTYTMIVLYRCVCTRNYAEW 926

  Fly   855 RSSWHE--SEAPYKQTEQILEGVPTQIAGHKHRIECLVSDGAYIISCCLKGQIRVWDARSGEQLT 917
            |:||.|  ||...|..:.:|||||.|:.||.|||||||:||..:.|.||:||::|||..:||.|.
Mosquito   927 RASWQESDSETEPKPEQCLLEGVPVQVDGHVHRIECLVTDGNMVASSCLQGQVKVWDVSNGELLA 991

  Fly   918 SISR----------------------------------------------------SDIQIS--- 927
            .|.|                                                    |.:..|
Mosquito   992 EIDRLHYFELQQHRGSSASPQSLPSPPTAGVLLRNDLGEPITGLQEAFPVAGGSSSSPVSCSPPG 1056

  Fly   928 ----------------------------QQRTD------------------------------GQ 934
                                        |..||                              |.
Mosquito  1057 TAVAASFKLRKKLHFNFSSLDGGAAASAQAATDSKLFDFQAQYERFFTPCSPPAANGAVNGGSGC 1121

  Fly   935 TLVRKLA-------------------------------------------------VSPVWCLDY 950
            .|..:.|                                                 |||:||||:
Mosquito  1122 DLRNRFASNGAPVASWAESNASTEEQPSYSHWMARPTTLSNECPQPPGSPKQQQHHVSPIWCLDF 1186

  Fly   951 FDNLIAVGCANGRVELWESPAGLLKCAYQEDAKRNQGITHIHLNGDRVIVARLNGRLDFYRLETY 1015
            .||||.:|||:||:|.||..:|..||.:..:...|.|:|:|.|.|||||.|||:||:||:|||||
Mosquito  1187 LDNLIVIGCADGRLEFWEGSSGSFKCIHDAEHSHNNGVTNIKLTGDRVIAARLSGRIDFFRLETY 1251

  Fly  1016 YKGKQIDWGFTSAYRRTHVRTGSTGSLGLMLQQQRCQQEASQKTTKEEMKITLEGVRLAHQQPIT 1080
            .:|:||||||||||||||:||||.||||.:.............:..||::..||..:..||||:|
Mosquito  1252 NQGRQIDWGFTSAYRRTHMRTGSAGSLGSLQAAMAASSGPGSHSASEELRCLLEFQQQGHQQPVT 1316

  Fly  1081 CMQVVNDMVFTGSQDHTLKVYCLNKSDVEYTLHGHCGPVTCLFVDRWQPGTGGSGSQDGLLCVWD 1145
            |::|..:.|.|||||||||||..:...:.|||||||||:||||:|:||.|..|||||||||||||
Mosquito  1317 CLEVAGNTVMTGSQDHTLKVYRADSHVMLYTLHGHCGPITCLFIDQWQSGMAGSGSQDGLLCVWD 1381

  Fly  1146 LFTGACMYNIQAHDGAVSCLACAPSYVISLGTDERICVWERFQGNLLTTINISNAYSSLLMLTPS 1210
            |.||||||.|||||.::..|..:||||||||.||||.||:||||:.|.||.:|:|||:|:|||||
Mosquito  1382 LTTGACMYKIQAHDDSIVALVGSPSYVISLGLDERIRVWDRFQGHPLNTITVSHAYSALVMLTPS 1446

  Fly  1211 LLVTSKMGSLIVWDVRTGQPAREVKLDFANLQLCPKIMMLACDSVVCDYGNEIRVVRFPIV-ADK 1274
            ||||.|.|:|:|||.|:|:.|||||||.:|:|||||||:.||.||:|||||::|:||||:| |||
Mosquito  1447 LLVTGKPGALVVWDARSGEVAREVKLDCSNMQLCPKIMLPACGSVICDYGNQMRIVRFPLVAADK 1511

  Fly  1275 C 1275
            |
Mosquito  1512 C 1512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCAP	NP_788277.1	Sterol-sensing	390..543	CDD:463544	112/152 (74%)
		WD40	878..1185	CDD:475233	179/468 (38%)
		WD40 repeat	887..942	CDD:293791	27/216 (13%)
		WD40 repeat	945..983	CDD:293791	19/37 (51%)
		WD40 repeat	989..1070	CDD:293791	46/80 (58%)
		WD40 repeat	1079..1114	CDD:293791	18/34 (53%)
		WD40 repeat	1120..1157	CDD:293791	29/36 (81%)
		WD40 repeat	1162..1196	CDD:293791	21/33 (64%)
		WD40 repeat	1201..1233	CDD:293791	21/31 (68%)
SCAP	XP_061509303.1	None