Protein Alignment SCAP and npc1l1

DIOPT Version :9

• Sequence 1: NP_788277.1
• Gene: SCAP / 35529
• FlyBaseID: FBgn0033052
• Length: 1276
• Species: Drosophila melanogaster
• Sequence 2: XP_002932620.2
• Gene: npc1l1 / 100487339
• XenbaseID: XB-GENE-964011
• Length: 1316
• Species: Xenopus tropicalis
• Alignment Length: 1058
• Identity: 200/1058 - (18%)
• Similarity: 351/1058 - (33%)
• Gaps: 395/1058 - (37%)

  Fly    67 GLFLSSYPTCASSIAFMAILLSCYPLINIPLPGTIPTKIVVPYETGSGSLSWHSLNTSSTTPQEP 131
            |..::|||.....::.:.:::....:|.|.|. |.|.::            |.::|:.:...::.
 Frog   352 GTLVASYPKTVIGVSLIVVIILSAGIILIRLT-TDPVEL------------WSAVNSQARQEKDF 403

  Fly   132 HPSG-EPWPPEPQVLNSSTTDRSPPPLLPWAQSSPAFF-------------YVQQITLR---TSV 179
            |.:. .|:....|::.::....|.|       ....||             .::.:.|:   .::
 Frog   404 HDANFGPFFRTNQLIITAKNRVSYP-------YDSLFFGKLNFSGILSPDTIMEMLDLQEKVQNI 461

  Fly   180 LPWTEGMQ----LMDAFRAPLHE---------VFKLLEIVRNHQSS---ENKRTLEHNCLHVDNV 228
            :.|:|..|    |.|...|||:.         |..|::..:|.::.   |..:|:        :.
 Frog   462 VVWSEKHQKNVTLKDICYAPLNPSNPTPTDCCVNSLMQYFQNDRAKFDLEVTQTM--------SG 518

  Fly   229 KRGTHGQLDQIFPEYGCLLLSPANLWTQNSQNFTRDTNILN---------------TIFQYHNLQ 278
            :.||.|..|..             ::..||....:|...|.               .:..|.:.|
 Frog   519 QTGTVGWRDHF-------------MYCVNSPLSFKDITDLELSCMADYGAPVFPFLAVGGYKDGQ 570

  Fly   279 KSKVSAAEMLFGL---PMQDTGF-------KRYPLRARSRIIQYALTLFLKHNDMEYLDTLKEKL 333
            .|:..|..:.|.|   |..|..|       |||     ..||:            ||.:..|..|
 Frog   571 FSEAEALILTFSLNNYPRTDPRFDFVLLWEKRY-----LEIIK------------EYKENPKSNL 618

  Fly   334 LRHYPPLPLASASAEEPTTITYIFYPGEYRMWELVP-YTVAFMLVFAYV------YFSVRKIDVF 391
            ...|    :|..|.|:....|         ..|.:| :|::::::|.|:      |.|.|:: :.
 Frog   619 TFGY----MAERSLEDEINRT---------TTEDIPIFTISYLVIFIYIALALGEYSSCRRV-LV 669

  Fly   392 RSRFLLALCSVITTAGSLAMSLGLCFFFGLTISLQSKDIFPYLVILVGLENSLVITKSVVSMDET 456
            .|:..|.|..::...|::..|:|...:.|:..:|...::.|:||:.||.:|..:.... :..|:.
 Frog   670 DSKVTLGLGGILVVLGAVLSSIGFYSYIGIPSTLIIVEVVPFLVLAVGADNIFIFVLE-LQRDDR 733

  Fly   457 FDVKIRVAQALSKEGWHISKTLL----TEITILTIGLATFVPVIQEFCIFAIVGLLSDFMLQMLL 517
            ...:.|..| :.:...:::.::|    :|.....:|..|.:|.::.|.:.|.:.:|.||:||:.:
 Frog   734 RPGERREEQ-IGRVLGNVAPSMLLCSVSESLCFFLGALTKMPAVRTFALNAALAILLDFVLQISM 797

  Fly   518 FSTILAMNIKRTE------------YTAEAKHLPKMLLSCTQGAGRQDFRFFGAAPALPPFVPGT 570
            |..:::::.||.|            .|.:.|...|.||                       ||
 Frog   798 FVALVSLDSKRQEASRYDICCCIKTKTEKPKKKSKGLL-----------------------VP-- 837

  Fly   571 FQRSQSHPKLCFADPASVSDRTSLVNGHSSPEQRIPKRIKIVNFWARTRFFQRAFMIWMIVWICS 635
            |.:....|.|  .:|.|                               ||.   .|:..|...|:
 Frog   838 FMKKVYSPIL--LNPVS-------------------------------RFI---VMVVFIFMFCA 866

  Fly   636 IVYNSGYLEQLFSMQS----NGTMTATLE---------LQRRLQAGRGAVSSFF---EGWQ---- 680
            .:|        |.|.:    |..::..|:         |.|.|:.|   |.::|   .|:.
 Frog   867 GLY--------FMMHTRVGLNQELSVPLDSYVLDYFDYLNRYLEVG---VPTYFVTTTGYNFSSL 920

  Fly   681 -----------ADGQRATSAPSGSGFST--PIKAPLAIDINETAEEMMRLRYPSFDLNYFLSN-- 730
                       .||...|....   ::|  |.::.|||..:...::.:....|:.|....|.|
 Frog   921 DGINGICSSVGCDGDSLTQKIQ---YATEYPDRSYLAIPASSWVDDFIDWLNPTSDCCRLLLNGT 982

  Fly   731 FHWST-----IMKQYNISLSGHYVTLLPTIRLSHAIAP--------------------------- 763
            |..||     .:::...|.:|   .|.|.:...:...|
 Frog   983 FCSSTSALPGCLRKCMPSTTG---ALRPNLEQFNTYLPVFLNDYPNLKCPKGGLGAYDNSVKFND 1044

  Fly   764 --ELA--------TLLRNPQEQLQQNFQWKALAAALDPLDFNDDDVRRESPMVMAEGLPLVPKSP 818
              |:|        |.|:|.||          ..|||        ...||....:.|.|..||.:.
 Frog  1045 QGEIAATRFMAFHTPLKNSQE----------YTAAL--------KTARELAANITESLRKVPGTD 1091

  Fly   819 MEIFFAILLCCISIFVLCYTMV-VFYRCICTRNYAEWRSSWHESEAPYKQTEQILEGVPTQIAGH 882
            .           :..|..||:. |||....|                     .:.||:.|...
 Frog  1092 P-----------NFRVFPYTITYVFYEQYMT---------------------IVQEGLFTLAL-- 1122

  Fly   883 KHRIECLVSDGAYIISCCLKGQIRVWDARSG--EQLTSISRSDIQISQQRTDGQTLVRKLAVSPV 945
                 ||:.  .:.:.|.|.|.    |.|||  ..:|.|              ..|:..:.|..:
 Frog  1123 -----CLIP--TFAVCCILLGM----DLRSGFINLITII--------------MILIDTMGVMTL 1162

  Fly   946 WCLDY----FDNLI-AVG 958
            |.:||    ..||: |||
 Frog  1163 WGIDYNAISLINLVTAVG 1180

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCAP	NP_788277.1	Sterol-sensing	390..542	CDD:289145	36/167 (22%)
		WD40	<878..1227	CDD:225201	21/88 (24%)
		WD40	878..1185	CDD:295369	21/88 (24%)
		WD40 repeat	887..942	CDD:293791	12/56 (21%)
		WD40 repeat	945..983	CDD:293791	8/19 (42%)
		WD40 repeat	989..1070	CDD:293791
		WD40 repeat	1079..1114	CDD:293791
		WD40 repeat	1120..1157	CDD:293791
		WD40 repeat	1162..1196	CDD:293791
		WD40 repeat	1201..1233	CDD:293791
npc1l1	XP_002932620.2	2A060601	31..1270	CDD:273337	200/1058 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910