DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Strica and CASP10

DIOPT Version :9

Sequence 1:	NP_001260718.1	Gene:	Strica / 35528	FlyBaseID:	FBgn0033051	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_116759.2	Gene:	CASP10 / 843	HGNCID:	1500	Length:	522	Species:	Homo sapiens

Alignment Length:	407	Identity:	103/407 - (25%)
Similarity:	161/407 - (39%)	Gaps:	86/407 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 LKGSRPKATWASFASTANSSTSSYVSPYRQKPSMAITCTSPNIKT--PKTTSSTSS---SSASSI 231
            ||.|.||....|.:..|      ::....:.....:||.....||  ||...:...   ..|..|
Human   138 LKDSLPKTEMTSLSFLA------FLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAIQI 196

  Fly   232 TSPPKPSSSVSSISSIFKSAPKQVDKPLSSTATPKPFIS-----------LGSSGGTKPKVTAVA 285
            .:||....:.|          .|.::.|.|....|.|:.           .||:|..........
Human   197 VTPPVDKEAES----------YQGEEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAPSL 251

  Fly   286 QSQDAQGTISTSLGISKSSLTKNKLKPARVY-----------IFNHERFDNKNEFRKGSAQDVKV 339
            .|:..||..:.:|....|:      |.|.||           |.|:..|.:..: |:|:.:|.::
Human   252 VSRGMQGASANTLNSETST------KRAAVYRMNRNHRGLCVIVNNHSFTSLKD-RQGTHKDAEI 309

  Fly   340 LRATFEQLKCKVEVITDATLVTIKKTVRMLQTKD-FEDKSALVLVILSHGTRHDQIAAKDDDYSL 403
            |...|:.|...|.:..:.|.|.::..::..:... ..|....|..||:|| |...:      ||.
Human   310 LSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHG-RFGAV------YSS 367

  Fly   404 DDDVV--------FPILRNRTLKDKPKLIFVQACKG-DCQLG-GFMTDAAQPNGSPN-------- 450
            |:.::        |..|:...|.:||||.|:|||:| :.|.. ....||..|..:|.
Human   368 DEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPA 432

  Fly   451 --EILKCYSTYEGFVSFR-TEDGTPFIQTLCEALNR-SGKTSDIDTIMMNV-----RQVVKMQSK 506
              :.|...:|..|:|||| .|:|:.:||:||..|.: ..:..||.:|:..|     |:|.|..:|
Human   433 EADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSILTAVNDDVSRRVDKQGTK 497

  Fly   507 DRQIPSVTSTLTSKYVF 523
             :|:|....||..|.||
Human   498 -KQMPQPAFTLRKKLVF 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Strica	NP_001260718.1	CASc	311..523	CDD:294037	70/250 (28%)
CASP10	NP_116759.2	DD	18..99	CDD:326335
		DED_Caspase_10_r2	112..190	CDD:260074	13/57 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	231..269		7/37 (19%)
		CASc	276..514	CDD:214521	69/247 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810