Protein Alignment Strica and CASP4

DIOPT Version :9

• Sequence 1: NP_001260718.1
• Gene: Strica / 35528
• FlyBaseID: FBgn0033051
• Length: 527
• Species: Drosophila melanogaster
• Sequence 2: NP_001216.1
• Gene: CASP4 / 837
• HGNCID: 1505
• Length: 377
• Species: Homo sapiens
• Alignment Length: 334
• Identity: 75/334 - (22%)
• Similarity: 123/334 - (36%)
• Gaps: 98/334 - (29%)

  Fly   277 TKPKVTAVAQSQD------AQGTISTSLGISKSSLTKN-------------------KLKPARVY 316
            |:.||..:|.|..      .|..:.|...|.:.|..|.                   ||.|
Human    50 TEDKVRVMADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCP---- 110

  Fly   317 IFNHERF-----------------DNK---------NEF-----RKGSAQDVKVLRATFEQLKCK 350
               ||.|                 :|:         .||     |.|:..|:..::...|.|...
Human   111 ---HEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYS 172

  Fly   351 VEVITDATLVTIKKTVRMLQTK-DFEDKSALVLVILSH-------GTRHDQIAAKDDDYSLDDDV 407
            |:|..:.|...::..:|...|: :.:...:..||::||       ||.||:   |..|..| .|.
Human   173 VDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDE---KKPDVLL-YDT 233

  Fly   408 VFPILRNR---TLKDKPKLIFVQACKGDCQLGGFMTDA------AQPNGSPN-EILKCYSTY--E 460
            :|.|..||   :||||||:|.||||:|..:...::.|:      |....|.| |....|.|:  :
Human   234 IFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEK 298

  Fly   461 GFVSFRTED-----------GTPFIQTLCEALNRSGKTSDIDTIMMNVRQVVKMQSKDRQIPSVT 514
            .|::|.:..           |:.||..|.....:......::.:...|:|..:......|:|::.
Human   299 DFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIE 363

  Fly   515 STLTSKYVF 523
            ....::|.:
Human   364 RLSMTRYFY 372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Strica	NP_001260718.1	CASc	311..523	CDD:294037	63/273 (23%)
CASP4	NP_001216.1	Required for LPS-binding. /evidence=ECO:0000250|UniProtKB:P70343	1..59		3/8 (38%)
		CARD_CASP1-like	5..81	CDD:260036	8/30 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	84..104		1/19 (5%)
		CASc	126..375	CDD:214521	59/251 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810