DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Strica and Casp8

DIOPT Version :9

Sequence 1:	NP_001260718.1	Gene:	Strica / 35528	FlyBaseID:	FBgn0033051	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_071613.1	Gene:	Casp8 / 64044	RGDID:	620945	Length:	482	Species:	Rattus norvegicus

Alignment Length:	299	Identity:	79/299 - (26%)
Similarity:	125/299 - (41%)	Gaps:	52/299 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 LGSSGGTK------PKVTAVAQSQ-DAQGTISTSLGISKSSLTKNKLKPARVY--IFNHERFDNK 326
            :.:.||.:      .:||...|.. |:.|. ..|..::..::.:.|.|| |.|  |||:..|...
  Rat   187 MSTEGGEELPVSVLDEVTIKMQDMWDSPGE-QESESLNSDNVYQMKSKP-RGYCLIFNNNNFSKA 249

  Fly   327 NE---------FRKGSAQDVKVLRATFEQLKCKVEVITDATLVTIKKTVRMLQTKDFEDKSALVL 382
            .|         .|||:..|.:.|..||::|..::...:|.|...|.:.:...|:||.:.|...:.
  Rat   250 REDIPKLSNMRDRKGTNYDEEALSKTFKELHFEIVSFSDCTASQIHEVLVSYQSKDHKGKDCFIC 314

  Fly   383 VILSHGTRHDQIAAKDDDYSLDD-DVVFPILRNRTLKDKPKLIFVQACKGDCQLGGFMTDAAQP- 445
            .|||||.:.........:.|:.: ...|...:..:|..|||:.|:|||:|:    .|......|
  Rat   315 CILSHGDKGIVYGTDGKEASIYELTSYFTGSKCPSLAGKPKIFFIQACQGN----NFQKAVPVPD 375

  Fly   446 ------------------NGSPNE--ILKCYSTYEGFVSFRTED-GTPFIQTLCEAL-NRSGKTS 488
                              |..|:|  .|...:|.:..||:|... ||.:||:||::| .|..:..
  Rat   376 ETGLEQEHVLEEDSSSYKNYIPDEADFLLGMATVKNCVSYRDPTRGTWYIQSLCQSLRERCPRGE 440

  Fly   489 DIDTIMMNVRQVVKMQSKDR----QIPSVTSTLTSKYVF 523
            ||.:|:..|...|..:...|    |:|....||..|..|
  Rat   441 DILSILTGVNYDVSNKDNPRNMGKQMPQPIFTLRKKLFF 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Strica	NP_001260718.1	CASc	311..523	CDD:294037	69/250 (28%)
Casp8	NP_071613.1	DED_Caspase_8_r1	3..84	CDD:260041
		DD	98..179	CDD:417479
		CASc	227..480	CDD:237997	71/258 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810