DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Strica and casp8

DIOPT Version :9

Sequence 1:	NP_001260718.1	Gene:	Strica / 35528	FlyBaseID:	FBgn0033051	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	XP_005165894.1	Gene:	casp8 / 58022	ZFINID:	ZDB-GENE-000713-1	Length:	477	Species:	Danio rerio

Alignment Length:	268	Identity:	74/268 - (27%)
Similarity:	110/268 - (41%)	Gaps:	46/268 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   292 GTISTSLGISKSSLTKNKLKPARVYIF------------NHERFDNKNEF-RKGSAQDVKVLRAT 343
            |||:|.        .:..|.|...||.            |:....:.|.. |.|:..|...|...
Zfish   215 GTITTD--------AETPLNPNEYYILTQRPLGYCLIINNYNFLKSTNLLKRTGTDMDKDRLAKL 271

  Fly   344 FEQLKCKVEVITDATLVTIKKTVRMLQTKDFEDKSALVLVILSHGTRHDQIAAKDDDYSLDDDVV 408
            |.::..::||.:|.....||..::....|:.....|.|..|||||.:...:........: .:|.
Zfish   272 FSRMHFQIEVRSDLEAWAIKDEIKQFANKNHASMGAFVCCILSHGEKGTVLGTDGKPVEI-REVT 335

  Fly   409 FPILRNRTLKDKPKLIFVQACKGDCQLGGFMT-----DAAQPNGSPNE---------------IL 453
            .|....|||..||||.|:|||:||....|..|     ||.:.:....|               .|
Zfish   336 LPFAGCRTLASKPKLFFIQACQGDENQAGVWTSDGREDAPEEDEKYEEDAGIIVLRKIPIEADFL 400

  Fly   454 KCYSTYEGFVSFR-TEDGTPFIQTLCEALNR-SGKTSDIDTIMMNVR-QVVKMQSKD-RQIPSVT 514
            ...:|.|.::|:| |::|:.|||.||:.:.. ..|..|:.:|:..|. :|.|...|. :|:|...
Zfish   401 IGMATVEHYLSYRHTKEGSIFIQELCKKMEELCPKKEDMLSILTKVNFEVSKRILKGYKQMPEPR 465

  Fly   515 STLTSKYV 522
            .|||.|.|
Zfish   466 YTLTKKLV 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Strica	NP_001260718.1	CASc	311..523	CDD:294037	69/249 (28%)
casp8	XP_005165894.1	DED_Caspase_8_10_r1	2..76	CDD:260059
		DED_Caspase_8_10_r2	96..176	CDD:260042
		CASc	230..475	CDD:237997	68/245 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810