DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pngl and PNG1

DIOPT Version :9

Sequence 1:	NP_610192.1	Gene:	Pngl / 35527	FlyBaseID:	FBgn0033050	Length:	631	Species:	Drosophila melanogaster
Sequence 2:	NP_015229.1	Gene:	PNG1 / 856009	SGDID:	S000006017	Length:	363	Species:	Saccharomyces cerevisiae

Alignment Length:	345	Identity:	103/345 - (29%)
Similarity:	149/345 - (43%)	Gaps:	60/345 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 IAFPRVLRTNNNFLQSLELYSDAVMQYEDNLLLATGRTLIPVEELTEMASEKLI--DIQDQIASG 212
            |.|..::.| |.|.|.:...|..:....||   .:..:::     .|.....||  ::..:.|..
Yeast    40 IRFQNLVHT-NQFAQGVLGQSQHLCTVYDN---PSWHSIV-----LETLDLDLIYKNVDKEFAKD 95

  Fly   213 ERQEKEPCVRDLLLVELVNWFNTQFFQWVNNIPCRVCG----------------SEESRLRRTER 261
            ...|.|....|.|:.||:.:|...||:|.|...|..||                .|||:....
Yeast    96 GHAEGENIYTDYLVKELLRYFKQDFFKWCNKPDCNHCGQNTSENMTPLGSQGPNGEESKFNCG-- 158

  Fly   262 EGDIRVEVTVC--CGQESKFYRYNDISQLLVSRKGRCGEYANCFTFLCRALDYDARIVHSHFDHV 324
                .||:..|  ||..::|.||||..:||.:|||||||:.|.||.:.::...|.|.|.:..|||
Yeast   159 ----TVEIYKCNRCGNITRFPRYNDPIKLLETRKGRCGEWCNLFTLILKSFGLDVRYVWNREDHV 219

  Fly   325 WTEVYSEAQMRWLHVDPSENVIDSPLMYQHGWKRHIDYILAYSRDDIQDVTWRY------TNDHQ 383
            |.|.:|....||:|||..|...|.|.:|...|.:.:.|.:|:.:|.:.||:.||      ..|..
Yeast   220 WCEYFSNFLNRWVHVDSCEQSFDQPYIYSINWNKKMSYCIAFGKDGVVDVSKRYILQNELPRDQI 284

  Fly   384 KILHLRKLCGEKEMVQTLDAIRAKRRQNCTADRKLFLSQRNMYEVI----GLTLERK------PT 438
            |...|:.||         ..|..:.|.:...|....|:.|:..|.|    |.|.|.|      .:
Yeast   285 KEEDLKFLC---------QFITKRLRYSLNDDEIYQLACRDEQEQIELIRGKTQETKSESVSAAS 340

  Fly   439 ENELKGRSSGSLSWRQSRGE 458
            ::..:||.|||..|:..|||
Yeast   341 KSSNRGRESGSADWKAQRGE 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pngl	NP_610192.1	PUB	30..107	CDD:286494
		CitX	98..>185	CDD:294885	9/34 (26%)
		Transglut_core	<278..341	CDD:280085	30/62 (48%)
		YebA	<282..378	CDD:224224	39/95 (41%)
		Rad4	<325..>383	CDD:281786	21/63 (33%)
		PAW	444..630	CDD:282564	9/15 (60%)
PNG1	NP_015229.1	TGc	183..237	CDD:214673	26/53 (49%)
PNG1	NP_015229.1	sm_acid_XPC-like	<220..>274	CDD:415878	19/53 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342213
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10117
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S984
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004891
OrthoInspector	1	1.000	-	-		oto99861
orthoMCL	1	0.900	-	-		OOG6_103952
Panther	1	1.100	-	-	LDO	PTHR12143
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R941
SonicParanoid	1	1.000	-	-		X3448
TreeFam	0	0.000	Not matched by this tool.
	11	10.820