DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pngl and PNG1

DIOPT Version :9

Sequence 1:	NP_610192.1	Gene:	Pngl / 35527	FlyBaseID:	FBgn0033050	Length:	631	Species:	Drosophila melanogaster
Sequence 2:	NP_199768.1	Gene:	PNG1 / 835019	AraportID:	AT5G49570	Length:	721	Species:	Arabidopsis thaliana

Alignment Length:	490	Identity:	144/490 - (29%)
Similarity:	225/490 - (45%)	Gaps:	83/490 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LEAVRILLVLLENILAQPENSMFRTIRQENKAIKEK--LLSLPGCERL-LEAIGFVRAPSSNAYT 94
            ||.:|.|:..|  .|..||.... ....:|:.:.::  |.||  .||| |.::|.....:|:|..
plant    25 LEVLRFLIFSL--TLVPPEEQKI-VAEDDNRLVSDESDLASL--SERLRLVSVGEDSVENSDAEM 84

  Fly    95 LPTEVSLQQVKKYRDALSERRTAWLNGTVSKSPPQQSTTSTTPLFIKPSVEYRHRIAFPRVLRTN 159
            |.::..|.::.:..:                                .::.::..:|    .|.|
plant    85 LKSDEELARMLQAEE--------------------------------DAIMFQQFVA----ARDN 113

  Fly   160 NNFLQSLELYSDAVMQYEDNLLLATGRTLIPVEELTEMASEKLIDIQDQIASGERQEKEPCVRD- 223
            ..|...:..|...|:.|||.:.....|..:|.:||.|.|   |:.:..: .:.|..::|   ||
plant   114 GEFEGRIRPYVSQVLMYEDPVRQDAARKTVPKDELEEKA---LVSLAKE-GNFEPSKEE---RDY 171

  Fly   224 LLLVELVNWFNTQFFQWVNNIPCRVCGSEE------SRLRRTEREGDIRVEVTVC--CGQESKFY 280
            ..|::|:.||. :.|:|||..||..||::.      :.|......|..|||:..|  |...::|.
plant   172 AFLLQLLFWFK-KSFRWVNEPPCDFCGNKTIGQGMGNPLTSELAYGANRVEIYRCTMCPTTTRFP 235

  Fly   281 RYNDISQLLVSRKGRCGEYANCFTFLCRALDYDARIVHSHFDHVWTEVYSEAQMRWLHVDPSENV 345
            ||||..:|:.::||||||:|||||..||...||:|::....||||||.||.:..||:|:||.|.|
plant   236 RYNDPLKLVETKKGRCGEWANCFTLYCRTFGYDSRLIMDFTDHVWTECYSHSLKRWIHLDPCEGV 300

  Fly   346 IDSPLMYQHGWKRHIDYILAYSRDDIQDVTWRYTNDHQKILHLRKLCGEKEMVQTLDAIRAKRRQ 410
            .|.|::|:.||.:.::|::|.|:|.:.|||.|||....::|..|.|..|..:...|..:..:||:
plant   301 YDKPMLYEKGWNKKLNYVIAISKDGVCDVTKRYTKKWHEVLSRRTLTTESSLQDGLRTLTRERRR 365

  Fly   411 NCTAD--RKLFLSQRNMYEVIGLTLERKPTEN-ELKGRSSGSLSWRQSRGEHTFTNIFVFNLSAT 472
            :...:  .||.|..||..|.:...|......: .|.||.||...||..|.|.........:.|:.
plant   366 SLMFESLSKLELRDRNEQEELERNLHSADNASVSLPGRQSGDREWRIMRSEFGSDENSSVSSSSC 430

  Fly   473 ELQKRQLNVRYSCATDTYERYAKEGEHIT-ILDSY 506
            .::|        |..|          |:| |.||:
plant   431 PVRK--------CVDD----------HVTNIYDSF 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pngl	NP_610192.1	PUB	30..107	CDD:286494	21/76 (28%)
		CitX	98..>185	CDD:294885	10/86 (12%)
		Transglut_core	<278..341	CDD:280085	33/62 (53%)
		YebA	<282..378	CDD:224224	47/95 (49%)
		Rad4	<325..>383	CDD:281786	27/57 (47%)
		PAW	444..630	CDD:282564	17/64 (27%)
PNG1	NP_199768.1	Transglut_core	199..296	CDD:280085	40/96 (42%)
PNG1	NP_199768.1	Rad4	<280..>347	CDD:281786	29/66 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	56	1.000	Domainoid score	I4071
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004891
OrthoInspector	1	1.000	-	-		oto4173
orthoMCL	1	0.900	-	-		OOG6_103952
Panther	1	1.100	-	-	LDO	PTHR12143
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3448
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.910