DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pngl and NGLY1

DIOPT Version :9

Sequence 1:	NP_610192.1	Gene:	Pngl / 35527	FlyBaseID:	FBgn0033050	Length:	631	Species:	Drosophila melanogaster
Sequence 2:	NP_060767.2	Gene:	NGLY1 / 55768	HGNCID:	17646	Length:	654	Species:	Homo sapiens

Alignment Length:	643	Identity:	220/643 - (34%)
Similarity:	338/643 - (52%)	Gaps:	78/643 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EAYLEAVRILLVLLENILAQPENSMFRTIRQENKAIKEKLLSLPGCERLLEAIGFVRAPSSNAYT 94
            |.:|||.::||...:|||..|.:..:|:||..|.|...:||.:.|....|..:||....:...:
Human    26 ETFLEASKLLLTYADNILRNPNDEKYRSIRIGNTAFSTRLLPVRGAVECLFEMGFEEGETHLIF- 89

  Fly    95 LPTEVSLQQVKKYRDALSERRTAWLNGT-------VSKSPPQQSTTSTTPLFIKPSVEYRH---- 148
             |.:.|::|::|.||.::..|::.|:|:       .|:.|...:...||| ...||...:|
Human    90 -PKKASVEQLQKIRDLIAIERSSRLDGSNKSHKVKSSQQPAASTQLPTTP-SSNPSGLNQHTRNR 152

  Fly   149 --RIAFP---RVLRTNNNFLQSLELYSDAVMQYEDNLLLATGRTLIPVEELTEMASEKL------ 202
              :.:.|   ..:..::..|:.|:.....|:.||:..|.......|||:||...:.|||
Human   153 QGQSSDPPSASTVAADSAILEVLQSNIQHVLVYENPALQEKALACIPVQELKRKSQEKLSRARKL 217

  Fly   203 ---IDIQDQIASGERQEKEPCVRDLLLVELVNWFNTQFFQWVNNIPCRVCG----SEESRLRRTE 260
               |:|.|:              |.||:||::||..:||.||||:.|..||    |.:..|..::
Human   218 DKGINISDE--------------DFLLLELLHWFKEEFFHWVNNVLCSKCGGQTRSRDRSLLPSD 268

  Fly   261 RE---GDIRVEVTVC--CGQESKFYRYNDISQLLVSRKGRCGEYANCFTFLCRALDYDARIVHSH 320
            .|   |...||...|  |...::|.|||:..:||.:|.|||||:|||||..|||:.::||.|..:
Human   269 DELKWGAKEVEDHYCDACQFSNRFPRYNNPEKLLETRCGRCGEWANCFTLCCRAVGFEARYVWDY 333

  Fly   321 FDHVWTEVYSEAQMRWLHVDPSENVIDSPLMYQHGWKRHIDYILAYSRDDIQDVTWRYTNDHQKI 385
            .|||||||||.:|.||||.|..|:|.|.||:|:.||.:.:.|::|:|:|::.||||||:..|:::
Human   334 TDHVWTEVYSPSQQRWLHCDACEDVCDKPLLYEIGWGKKLSYVIAFSKDEVVDVTWRYSCKHEEV 398

  Fly   386 LHLRKLCGEKEMVQTLDAIRAKRRQNCTADRKLFLSQRNMYEVIGLTLERKPTENELKGRSSGSL 450
            :..|....|..:..|::.:..:|:...:.:|:..|.||.:.|::.....:.|...||.||.|||:
Human   399 IARRTKVKEALLRDTINGLNKQRQLFLSENRRKELLQRIIVELVEFISPKTPKPGELGGRISGSV 463

  Fly   451 SWRQSRGE---HTFTNIFVFNLSATELQK--RQLNVRYSCATDTYERYAKEGEHITILDSYKTWQ 510
            :||.:|||   .....:|:    ..|.:|  :||::.|:...|.|.|.:...:.|:      .|:
Human   464 AWRVARGEMGLQRKETLFI----PCENEKISKQLHLCYNIVKDRYVRVSNNNQTIS------GWE 518

  Fly   511 KAQFSSKNIFRKVERDWKMAYLARLEDTDCGEIAWTFDFSKTNLKVKSYNLVFETKTFGDGKI-- 573
            ...:..::||||||.||.|.||||.|.:....|:|.|:.....|||.|.::...::||..|.:
Human   519 NGVWKMESIFRKVETDWHMVYLARKEGSSFAYISWKFECGSVGLKVDSISIRTSSQTFQTGTVEW 583

  Fly   574 -----SVTVDAT-DGS----ASVENATGFKIVAKLTGGKGDVAWQHTQLFRQSLNSRD 621
                 :..|:.| |.|    |....||...:.|:|:.|.||||||||||||||||..:
Human   584 KLRSDTAQVELTGDNSLHSYADFSGATEVILEAELSRGDGDVAWQHTQLFRQSLNDHE 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pngl	NP_610192.1	PUB	30..107	CDD:286494	24/76 (32%)
		CitX	98..>185	CDD:294885	23/102 (23%)
		Transglut_core	<278..341	CDD:280085	37/62 (60%)
		YebA	<282..378	CDD:224224	52/95 (55%)
		Rad4	<325..>383	CDD:281786	30/57 (53%)
		PAW	444..630	CDD:282564	71/195 (36%)
NGLY1	NP_060767.2	PUB_PNGase	19..109	CDD:198417	27/84 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..163		11/51 (22%)
		Transglut_core	275..354	CDD:307794	41/78 (53%)
		Rad4	<338..>391	CDD:281786	28/52 (54%)
		PAW	457..651	CDD:309732	71/195 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143700
Domainoid	1	1.000	108	1.000	Domainoid score	I6490
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10117
Inparanoid	1	1.050	340	1.000	Inparanoid score	I2368
Isobase	1	0.950	-	0	Normalized mean entropy	S984
OMA	1	1.010	-	-		QHG49076
OrthoDB	1	1.010	-	-		D522988at33208
OrthoFinder	1	1.000	-	-		FOG0004891
OrthoInspector	1	1.000	-	-		oto90535
orthoMCL	1	0.900	-	-		OOG6_103952
Panther	1	1.100	-	-	LDO	PTHR12143
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R941
SonicParanoid	1	1.000	-	-		X3448
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.890