Protein Alignment Pngl and Y50D4B.4

DIOPT Version :10

• Sequence 1: NP_610192.1
• Gene: Pngl / 35527
• FlyBaseID: FBgn0033050
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_001300267.1
• Gene: Y50D4B.4 / 3565176
• WormBaseID: WBGene00021743
• Length: 791
• Species: Caenorhabditis elegans
• Alignment Length: 746
• Identity: 150/746 - (20%)
• Similarity: 239/746 - (32%)
• Gaps: 265/746 - (35%)

  Fly     9 VHQIEP-------------------KT---RSAG--QQQQERGLKEAYLEAVRILLVLLENILAQ 49
            :|:|:|                   ||   |..|  |...|.|..||.||.       .||.|..
 Worm   131 LHKIKPDEEGMIYWKFNLKATDKVVKTLVIRMIGINQTLNEGGKAEACLET-------FENCLEA 188

  Fly    50 PEN-----------SMFRTIR-QENKAIKEKLLSLPGCERLLEAIGFVRAPSSNAYTLPTEVSLQ 102
            |.|           ::|..:: .:|..:........|||.|  ..||    |..||.:.|:..|.
 Worm   189 PANQDLTIDMPRADTLFLGVKLYKNIKVFRYAEECMGCEEL--ESGF----SVKAYWVSTQDHLL 247

  Fly   103 QVKK-YRD------ALSERRTA--------WLNGTVSKSPPQQSTTSTTPLF----IKPSVEYRH 148
            .:.. :.|      |||.:...        :||.:.|.:.|..|...   ||    ::...:|..
 Worm   248 NISSTFHDDSGRVFALSPKTGENYAKFTYNFLNNSYSHNEPDGSPVR---LFDFNGLERVEDYTE 309

  Fly   149 RIAFPRVLRTNN-----NFLQSLELYSDAVMQYEDNLLLATGRTLIPVEELTEMASEKLIDIQDQ 208
            ...|   ||..|     |...:|:|..|.:.                    .|....|:|.| |:
 Worm   310 NTVF---LRRKNPKEKGNIKWALDLNIDGLS--------------------VETVVIKIIGI-DE 350

  Fly   209 IASGERQEKEPCVRDLLLVELVN-------------WFNTQFFQWVNNIPCRVCGSEESRLRRT- 259
            |.:| ......|..|  |..:||             :||..|.:...||..    .|:.::.:|
 Worm   351 IDNG-GGTAIACGHD--LTSIVNPRCGNIPFNGKITFFNNAFHRLYLNITL----DEDIQIFKTK 408

  Fly   260 -EREG---DIRVEVTVCCGQESKFYRY-----NDISQLLVSRKGRCGEYANCFTFLCRALDYDAR 315
             :.||   ::.|||.....::...:.:     |:..||....|.|..|:.
 Worm   409 LDDEGSLENVSVEVYWSDWRDDVPFHWTLKTQNESIQLGNRFKNRYFEFK--------------- 458

  Fly   316 IVHSHFDHVWTEVYSEAQMRWLHVDPSENVIDSPLMYQHGWKRHID------YILAYSRDDIQDV 374
                         |...:.::.|.:..|:.: .|.:.:: .:||.|      |:.....|:...:
 Worm   459 -------------YEIERGKYSHTNEDESAV-KPFLVKN-IERHADDDTYDVYLQKIKPDEEGMI 508

  Fly   375 TWRY----TNDHQKILHLRKLCGEKEMVQTLDA-----IRAKRRQNCT--------------ADR 416
            .|::    |:...|.|.:|.:    .:.|||:.     ...:..:|||              ||
 Worm   509 YWKFDLKATDKVVKTLVIRMI----GINQTLNGGGKAEACLETFENCTEIPVDEDLIIDMPRAD- 568

  Fly   417 KLFLSQRNMYEVIGLTLERKPTENELKGRSSGSLSWRQSRGEHTFTNIFVFNLSAT--------- 472
            .|||..: :|:  .:.:.||.   |...|.||.||....:.....|...:.|:|:|
 Worm   569 TLFLGVK-LYK--NIKIFRKA---ERCVRCSGLLSGFSVKAYWVSTQDHLLNISSTFHDDSGRVF 627

  Fly   473 ----ELQKRQLNVRYSCATDTYERYAKEGEHITILDSYKTWQKAQFSSKNIFRKVER--DW--KM 529
                :..:......|:...:.|.....:|..:.:.|               |..:||  |:  ..
 Worm   628 ALSPKTGENYAKFTYNFINNLYSHTEPDGSPVRLFD---------------FNGLERVEDYTENT 677

  Fly   530 AYLARLEDTDCGEIAWTFDFSKTNLKVKSYNLVFETKTFGDGKISVTVDATDGSASVENATGFKI 594
            .:|.|....:.|.|.|..     ||::             |||....|        |....|.:.
 Worm   678 VFLRRKNPKEKGNIRWAL-----NLRI-------------DGKYVEKV--------VIGIIGIEE 716

  Fly   595 VAKLTGGKGDVAWQHTQLFRQSLNSRDYPFD 625
            :|. .||.....|  ..|:    |..|.|.|
 Worm   717 IAN-RGGTARACW--NVLY----NCIDIPID 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pngl	NP_610192.1	PUB	29..109	CDD:462790	22/92 (24%)
		Transglut_core	<278..341	CDD:376628	8/67 (12%)
		Rad4	<325..>383	CDD:427539	11/67 (16%)
		PAW	444..630	CDD:461409	39/199 (20%)
Y50D4B.4	NP_001300267.1	PAW	83..170	CDD:214745	8/38 (21%)
		PAW	266..353	CDD:214745	22/113 (19%)
		PAW	449..536	CDD:214745	19/120 (16%)
		PAW	632..706	CDD:214745	18/106 (17%)