DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pngl and C04E12.5

DIOPT Version :9

Sequence 1:	NP_610192.1	Gene:	Pngl / 35527	FlyBaseID:	FBgn0033050	Length:	631	Species:	Drosophila melanogaster
Sequence 2:	NP_001309618.1	Gene:	C04E12.5 / 182210	WormBaseID:	WBGene00015435	Length:	484	Species:	Caenorhabditis elegans

Alignment Length:	350	Identity:	65/350 - (18%)
Similarity:	120/350 - (34%)	Gaps:	101/350 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 VDPSENVIDSPLMYQHGWKRHIDYILAYSRDDIQDVTWRYT--NDHQKILH-LRKLCGEKEMVQT 400
            ||..|.|:|.        |.:..|:.....||..::.|.::  ||.:.:.. :..:.|.:|:|..
Worm   155 VDKIERVVDR--------KNNEAYLHQEFPDDFSNMYWAFSLKNDGKSVEKVVISIPGIEEIVNN 211

  Fly   401 LDAIRAKRRQNC----------TADRKLFLSQR--NMYEVIGLTLERKPTENELKGRSS------ 447
                ||...:.|          ..::.|.:.|:  .:|..|.|..:.|..:.:|||.|:
Worm   212 ----RAGVVETCPNFLINCFNIPVEKSLTIEQQMDKLYISIMLQKDIKVLKTKLKGVSNVESFKI 272

  Fly   448 -----------------GSLSWRQSRGEHTFTNIFVFNLSATELQKRQ-------------LNVR 482
                             ||::..:|............::|:|.|.:.|             ....
Worm   273 EVYWKNMTMDSPTTTTPGSIATTKSSTTTITETHHQPDISSTRLTEHQDIIQLTPKSGQDYAKFT 337

  Fly   483 YSCATDTYERYAKEGEHITILDSYKTWQKAQFSSKNIFRKVERDWKMAYLARLEDTD--CGEIAW 545
            |...::||.:..::|..:           ..:.:.|:...|:|...:||:...|..:  .|.|.|
Worm   338 YDVISNTYSQSNEDGSPV-----------KPYLASNVEHVVDRRLNVAYIHMKEPINKRIGLINW 391

  Fly   546 TFDFSKTNLKVKSYNLVFETKTFGDGKI---------------SVTVDATDGSASVENATGFKIV 595
            .|||......|:.    .|.|..|..:|               ..|....:||.::|.....|..
Worm   392 EFDFRFPGRSVEK----LEIKLTGMDEIVHNGGTANACLHDSFKCTAIPINGSLTIEKPQFNKFF 452

  Fly   596 AKLTGGKGDVAWQHTQLFRQSLNSR 620
            .::.      .::..::|:..||.|
Worm   453 MQIE------LFKDIKVFKTELNDR 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pngl	NP_610192.1	PUB	30..107	CDD:286494
		CitX	98..>185	CDD:294885
		Transglut_core	<278..341	CDD:280085	1/1 (100%)
		YebA	<282..378	CDD:224224	10/38 (26%)
		Rad4	<325..>383	CDD:281786	12/45 (27%)
		PAW	444..630	CDD:282564	38/229 (17%)
C04E12.5	NP_001309618.1	PAW	123..210	CDD:214745	14/62 (23%)
C04E12.5	NP_001309618.1	PAW	328..415	CDD:214745	20/101 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157784
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930