Protein Alignment Act42A and Actl6b

DIOPT Version :10

• Sequence 1: NP_523625.1
• Gene: Act42A / 35526
• FlyBaseID: FBgn0000043
• Length: 376
• Species: Drosophila melanogaster
• Sequence 2: NP_001412719.1
• Gene: Actl6b / 83766
• MGIID: 1933548
• Length: 434
• Species: Mus musculus
• Alignment Length: 436
• Identity: 157/436 - (36%)
• Similarity: 230/436 - (52%)
• Gaps: 75/436 - (17%)

  Fly     4 EEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVG--RPRHQGVMVGMGQKDS------------Y 54
            :||.|||.|.||...:||:||:|.|:|.||:.||  .....|.:...|:|:.            :
Mouse     9 DEVGALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLELEGEKEKKGKIFHIDTNALH 73

  Fly    55 V---GDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKAN 116
            |   |.|..|         |:::|::.:|:....|..||:...::..|..||||::|||.|.:|.
Mouse    74 VPRDGAEVMS---------PLKNGMIEDWECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAK 129

  Fly   117 REKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHT--VPIYEGYALPHAILRL 179
            |||:|::|||.:|.||.::...|||:.:|:||:||:||||  |.:||  :|:::||.|...|::.
Mouse   130 REKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDS--GATHTTAIPVHDGYVLQQGIVKS 192

  Fly   180 DLAGRDLTDYLMKILTERGYSFT---TTAEREIVRD-------IKEKLCYVA------------L 222
            .|||..::....::..|......   ..|.:|.||:       .||||..|:            .
Mouse   193 PLAGDFISMQCRELFQEMAIDIIPPYMIAAKEPVREGAPPNWKKKEKLPQVSKSWHNYMCNEVIQ 257

  Fly   223 DFEQEMATAASSSSLEK--------SYELPDGQVITIGNERFRCPESLFQPS----FLGMEACGI 275
            ||:..:...:.|...|:        .||:|:|.....|.||.|.||.||.||    ..|....|:
Mouse   258 DFQASVLQVSDSPYDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNVKGLSGNTMLGV 322

  Fly   276 HETTYNSIMKCDVDIR--------KDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIVA 332
            ......||..||:|||        :.||.:.:::||.|:..|..||:.:|::...|.:|::|::|
Mouse   323 GHVVTTSIGMCDIDIRPVDASPCSQGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIA 387

  Fly   333 ---PPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKC 375
               ..|||:|.||||||||||.||||||||||||:|.|...|.|||
Mouse   388 SNSTMERKFSPWIGGSILASLGTFQQMWISKQEYEEGGKQCVERKC 433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Act42A	NP_523625.1	ASKHA_NBD_actin	7..371	CDD:466823	151/427 (35%)
Actl6b	NP_001412719.1	Essential for mediating its function in dendritic development, may contribute to neuronal-specific targeting. /evidence=ECO:0000269|PubMed:17920018	39..82		8/42 (19%)