DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Act42A and Actl11

DIOPT Version :9

Sequence 1:	NP_523625.1	Gene:	Act42A / 35526	FlyBaseID:	FBgn0000043	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001019959.2	Gene:	Actl11 / 316000	RGDID:	1310036	Length:	1218	Species:	Rattus norvegicus

Alignment Length:	370	Identity:	151/370 - (40%)
Similarity:	225/370 - (60%)	Gaps:	21/370 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTL 68
            :::||:|:|.|:|..|.|.|.::...:|.||.|...:|.    ..||....|.:..:....:|
  Rat   867 QKMAAIVIDTGTGFTKCGLAQENHVLSVVPSQVQMLQHP----PQGQPQYVVPEHQEGSYSVL-- 925

  Fly    69 KYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAM 133
                ..|:|::||.:|.:|.|.||.:|||.|||..||:.::|::|:.||||:.:|:||.|:.|||
  Rat   926 ----NRGVVSDWDALEVLWQHLFYCKLRVQPEEMAVLVADSPISPRTNREKVAEILFERFHVPAM 986

  Fly   134 YVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERG 198
            ....||:|:|||.|||||:|:.||.|.|:..||..|...|....|||:||.||||||.::|...|
  Rat   987 QTVHQALLTLYAYGRTTGLVVGSGHGTSYVAPIITGDLAPLDTYRLDVAGADLTDYLAQLLMSGG 1051

  Fly   199 YSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPESLF 263
            :|   ..:..|||.|||..||||:|...||  |.:.|.::..:.|||..|||:|:|||.|||:||
  Rat  1052 HS---PPKGGIVRQIKEACCYVAMDTTTEM--ARNQSQVQVDFVLPDKHVITLGSERFCCPEALF 1111

  Fly   264 QPSFLGMEACGIHETTYNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKI 328
            ||:.||:...|:.:....||.:.:|..::.|.||.||.||:|:..|..:||::|   |.|..
  Rat  1112 QPNLLGLNQLGLPQLALLSISRLEVKQQEQLLANVVLEGGSTLINGFPERMRQE---LGPGA--- 1170

  Fly   329 KIVAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHR 373
            .::..|.|..:.|:||||:|...:||.:|:|::||:|.||..:::
  Rat  1171 TVLGSPHRAVAAWLGGSIMACRDSFQSLWLSRREYEEEGPWAIYK 1215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Act42A	NP_523625.1	PTZ00281	1..376	CDD:173506	151/370 (41%)
Actl11	NP_001019959.2	PHA03247	<200..485	CDD:223021
Actl11	NP_001019959.2	NBD_sugar-kinase_HSP70_actin	871..1215	CDD:418402	150/364 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900