DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Act42A and Actl7a

DIOPT Version :9

Sequence 1:	NP_523625.1	Gene:	Act42A / 35526	FlyBaseID:	FBgn0000043	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001011973.1	Gene:	Actl7a / 298017	RGDID:	1304697	Length:	440	Species:	Rattus norvegicus

Alignment Length:	374	Identity:	166/374 - (44%)
Similarity:	241/374 - (64%)	Gaps:	6/374 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTL 68
            |...|:|||.|:|.||.||||...|.....:.||:|..:....|..:|:::||.|..:....|.|
  Rat    72 EVTKAVVVDLGTGFCKCGFAGLPKPTHKISTTVGKPYMETAKTGDNRKETFVGRELFNPDIHLKL 136

  Fly    69 KYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAM 133
            ..|:.|||:.:||.::.||.:.|..|:::|||||.||:::.||:|..||||..:::|||||||||
  Rat   137 VNPLRHGIIVDWDTVQDIWEYLFRQEMKIAPEEHAVLVSDPPLSPHTNREKYAEMLFETFNTPAM 201

  Fly   134 YVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERG 198
            ::|.|:.||:|:.|||:|:|::.|.|||:.|||||||.||....|||.||.|||:|||.::...|
  Rat   202 HIAYQSRLSMYSYGRTSGLVVEVGHGVSYVVPIYEGYPLPSITGRLDYAGSDLTNYLMNLMNNCG 266

  Fly   199 YSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPESLF 263
            ..|:.. ...||.|||.|.|:||||..:|.....|...:.  |.||||:.|.:|.|||.|.|..|
  Rat   267 KHFSED-HLSIVEDIKTKCCFVALDPIEEKKIPPSEHEIH--YTLPDGKEIRLGQERFLCSEMFF 328

  Fly   264 QPSFLGMEACGIHETTYNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPS-TMK 327
            :||.:.....|:|..|.:.:.|||:.:::||..|.:|.||:||..|..:|:|||::::.|: |.:
  Rat   329 KPSLIKSMQLGLHTQTVSCLNKCDIALKRDLMGNILLCGGSTMLRGFPNRLQKELSSMCPNDTPQ 393

  Fly   328 IKIVAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF 376
            :.::  |||..:||.||||||||..||.:|:.:.||:|.||..::|:||
  Rat   394 VNVL--PERDTAVWTGGSILASLQGFQPLWVHRLEYEEHGPFFLYRRCF 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Act42A	NP_523625.1	PTZ00281	1..376	CDD:173506	164/372 (44%)
Actl7a	NP_001011973.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		ACTL7A_N	6..70	CDD:293445
		Required for interaction with TES. /evidence=ECO:0000250	36..56
		NBD_sugar-kinase_HSP70_actin	72..440	CDD:302596	164/372 (44%)
		ACTIN	74..440	CDD:214592	163/370 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810