DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Act42A and Actl7b

DIOPT Version :9

Sequence 1:	NP_523625.1	Gene:	Act42A / 35526	FlyBaseID:	FBgn0000043	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_079547.2	Gene:	Actl7b / 11471	MGIID:	1343053	Length:	418	Species:	Mus musculus

Alignment Length:	373	Identity:	167/373 - (44%)
Similarity:	238/373 - (63%)	Gaps:	6/373 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVG-RPRHQGVMVGMGQKDSYVGDEAQSKRGILTL 68
            ::.|||:|.||..||.|:||:..|.....|.|| |........|...|::|||.|..:....|.|
Mouse    50 KIKALVIDLGSQYCKCGYAGEPRPTYFISSTVGKRSAEMAADAGDNFKETYVGHELLNMEASLKL 114

  Fly    69 KYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAM 133
            ..|::||:|.:||.::.||.:.|:..:::.||||.||:::.||:|.:||||..:::||||..|||
Mouse   115 VNPLKHGVVVDWDCIQNIWEYIFHTAMKIMPEEHAVLVSDPPLSPTSNREKYAELLFETFGIPAM 179

  Fly   134 YVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERG 198
            :|..||:||:|:.|:|:|:|::||.||||.|||.||..||....|:|.||.|||:|||::|.|.|
Mouse   180 HVTSQALLSIYSYGKTSGLVVESGHGVSHVVPISEGDLLPGLPSRVDYAGCDLTNYLMQLLNEAG 244

  Fly   199 YSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPESLF 263
            :.|:.. ...|:..||:|.||.||..|:||:...  ..|...||||||::||||.|||||.|.||
Mouse   245 HKFSDD-HLHIIEHIKKKCCYAALLPEEEMSLGL--DELHVDYELPDGKIITIGQERFRCSEMLF 306

  Fly   264 QPSFLGMEACGIHETTYNSIMKCD-VDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMK 327
            :||.:|....|:.|.|...:.:|. ...::::.||.:|.||.||..|..:|.|:|::.|.|....
Mouse   307 KPSLVGCTQPGLPELTATCLARCQGTGFKEEMAANVLLCGGCTMLDGFPERFQRELSLLCPGDSP 371

  Fly   328 IKIVAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKC 375
             .:.|.||||.|||.||||||||..|||:|:||:|::|.|.:.::.||
Mouse   372 -TVAAAPERKTSVWTGGSILASLQAFQQLWVSKEEFEERGCAAIYSKC 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Act42A	NP_523625.1	PTZ00281	1..376	CDD:173506	167/373 (45%)
Actl7b	NP_079547.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42
		ACTIN	52..418	CDD:214592	165/369 (45%)
		NBD_sugar-kinase_HSP70_actin	53..418	CDD:302596	165/368 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810