DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src42A and Tec

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_445884.1	Gene:	Tec / 84492	RGDID:	620973	Length:	629	Species:	Rattus norvegicus

Alignment Length:	417	Identity:	165/417 - (39%)
Similarity:	250/417 - (59%)	Gaps:	29/417 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly  1183 TSLTTAKKGKSRRLSEFTRGEFLNEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYS 1247
            ::..|.||..:           |::..||.|...|.:|| :||..|::.|.|::||| |:...|:
  Rat   229 SNYVTGKKSNN-----------LDQYEWYCRNTNRSKAE-QLLRTEDKEGGFMVRDS-SQPGLYT 280

  Fly  1248 LSV-----RDGDT-VKHYRIRQ--LDEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQ 1304
            :|:     .:|.: .:||.|::  .....:::|.:..|.::.|::|::..::.||...|..|...
  Rat   281 VSLYTKFGGEGSSGFRHYHIKETATSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVST 345

  Fly  1305 IEK--PVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKD 1367
            ..|  |.|.|.|:   |:|||:.:.|.|:|:||||.||.|..|.|.....||||.::.|.|..:|
  Rat   346 KGKNAPTTAGFSY---DKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEED 407

  Fly  1368 FLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAA 1432
            |:.||::|.||.|.||:|||.|||.::||||:||.|:.|.||.:|:...|   ......|:.|..
  Rat   408 FIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQG---HFSRDVLLSMCQ 469

  Fly  1433 QIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEA 1497
            .:..||.|||..::|||||||||.||.:..:||::|||:||.:.:|:|.:..||:||:||..||.
  Rat   470 DVCEGMEYLERNSFIHRDLAARNCLVNEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEV 534

  Fly  1498 ANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLEC 1562
            .|||:||.||||||||:|:.|:.|.||:|:...||.||:|.|..|:|:|:|......|||:||.|
  Rat   535 FNYSRFSSKSDVWSFGVLMWEIFTEGRMPFEKNTNYEVVTMVTRGHRLPRPKLASKYLYEVMLRC 599

  Fly  1563 WHKDPMRRPTFETLQWKLEDFYTSDQS 1589
            |.:.|..||:||.|...:::....:::
  Rat   600 WQERPEGRPSFEDLLRTIDELVECEET 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	28/98 (29%)
		PTKc_Frk_like	1319..1587	CDD:270653	127/267 (48%)
		Pkinase_Tyr	1328..1580	CDD:285015	123/251 (49%)
Tec	NP_445884.1	PH_Btk	7..148	CDD:269944
		SH3_Tec	181..235	CDD:212838	1/5 (20%)
		SH2_Tec_Itk	238..345	CDD:198259	30/119 (25%)
		PTKc_Tec_Rlk	363..622	CDD:270685	124/261 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910