DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Src42A and STY17

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_195303.2	Gene:	STY17 / 829731	AraportID:	AT4G35780	Length:	570	Species:	Arabidopsis thaliana

Alignment Length:	601	Identity:	158/601 - (26%)
Similarity:	253/601 - (42%)	Gaps:	135/601 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1037 QEPEEKCASEEQMCTRNALTKSSSLDAISLSVAISPASSPSPPRPRRSLKQH-RCLQQHQQT--- 1097
            :|.||.|.|.                     ..::..:..||.:.|..|:.: ..||:.|::
plant     5 EETEESCGSR---------------------AVVASITKESPRQHRMKLEVYGEVLQRIQESNYE 48

  Fly  1098 ----------------PLAKKHSLDNCLQVVSSTTSRQPLRRWSNQTPLKCTCHPATEEL-PLTA 1145
                            .|..:::||..::......:.|.|        ||....|||..: .:..
plant    49 EANFPGFDDLLWLHFNRLPARYALDVNVERAEDVLTHQRL--------LKLAEDPATRPVFEVRC 105

  Fly  1146 IEKSRSL-----------PAAC-SASCSHTCAHLSVIDQSPATTKCFGKT----SLTTAKKGKSR 1194
            ::.|.:|           ||.. .|..|:....|     :|.|   ||.:    :||.|.|..::
plant   106 VQVSPTLNGNSGDVDPSDPAVNEDAQSSYNSRSL-----APPT---FGSSPNFEALTQAYKDHAQ 162

  Fly  1195 RLSEFTRGEFLNEKSWYFRKIKRIEAEKKL-----LLPE-----NEHGAFLIRDSESRHNDYSLS 1249
            ........:..|.:..:......|:..|.|     :|.|     .|..||...|.      :||.
plant   163 DDDSAVNAQLPNSRPMHEITFSTIDRPKLLSQLTSMLGELGLNIQEAHAFSTADG------FSLD 221

  Fly  1250 --VRDG----------DTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPC 1302
              |.||          |.:|. .||:..:......:..||      .||....::     |...|
plant   222 VFVVDGWSQEETEGLKDALKK-EIRKFKDQPCSKQKSITF------FEHDKSTNE-----LLPAC 274

  Fly  1303 VQIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDP-- 1365
            |:|.   |:|     .|:||||...||..:|:..|.:|:::.|.: .:..||||.||...::.
plant   275 VEIP---TDG-----TDEWEIDMKQLKIEKKVACGSYGELFRGTY-CSQEVAIKILKPERVNAEM 330

  Fly  1366 -KDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLID 1429
             ::|..|..||:|:||..::|....||....:.|:||.|..||:.::|....|   ..|:|:|:.
plant   331 LREFSQEVYIMRKVRHKNVVQFIGACTRSPNLCIVTEFMTRGSIYDFLHKHKG---VFKIQSLLK 392

  Fly  1430 MAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKED-EYEARVGARFPIKWT 1493
            :|..::.||.||...|.|||||...|:|:.:..:||:||||:||:..|. ...|..|.   .:|.
plant   393 VALDVSKGMNYLHQNNIIHRDLKTANLLMDEHEVVKVADFGVARVQTESGVMTAETGT---YRWM 454

  Fly  1494 APEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAE-VLTQVEHGYRMPQPPNCEPRLYE 1557
            |||...:..:..::||:|:.|:|.||:| |.:||..:|..: .:..|:.|.|...|....|:|.|
plant   455 APEVIEHKPYDHRADVFSYAIVLWELLT-GELPYSYLTPLQAAVGVVQKGLRPKIPKETHPKLTE 518

  Fly  1558 IMLECWHKDPMRRPTF 1573
            ::.:||.:||..||.|
plant   519 LLEKCWQQDPALRPNF 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	23/112 (21%)
		PTKc_Frk_like	1319..1587	CDD:270653	92/260 (35%)
		Pkinase_Tyr	1328..1580	CDD:285015	87/251 (35%)
STY17	NP_195303.2	ACT_TyrKc	178..244	CDD:153200	16/72 (22%)
STY17	NP_195303.2	STKc_MAP3K-like	301..541	CDD:270901	84/242 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm3398
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910